Hongen Liao

Zihan Li, Jialan Zheng, Ziyu Li et al.

Understanding the human brain requires access to its microscopic tissue architecture. Diffusion magnetic resonance imaging (MRI) provides the only noninvasive window into whole-brain microstructure in vivo, yet reliable quantitative mapping remains confined to specialized research settings requiring dense sampling and optimized acquisition protocols. To address this gap, we present a physics-informed generative microstructure network (PIGMENT) that learns a universal generative prior of human brain microstructure and adapts it zero-shot to each participant's measured data to recover subject-specific maps. Trained on 11375 scans spanning multiple sites, vendors, and field strengths, PIGMENT enabled reliable quantitative mapping for tensor, kurtosis, and NODDI models across external datasets from five independent centers. It remains effective where conventional fitting becomes unreliable, recovering meaningful maps from extremely sparse acquisitions while supporting downstream tractography and structural connectivity mapping. PIGMENT estimates demonstrated strong biological validity, preserving submillimeter cortical microarchitectural patterns and early-childhood white matter developmental trajectories from 10-fold accelerated scans. Furthermore, PIGMENT enables reliable quantitative tensor mapping on cost-efficient low-field systems and the extraction of tumor-related biomarkers using ultra-fast clinical protocols. Together, these results establish PIGMENT as a physics-informed foundation model that extends quantitative diffusion MRI into regimes traditionally too sparse, heterogeneous, or clinically constrained for reliable analysis.

Zhuhao Wang, Fang Chen, Chaohui Yu et al.

CT interpretation requires radiologists to review hundreds of volumetric slices per examination, making reporting time-consuming and highly expertise-dependent. Automated CT report generation offers a promising route to improving clinical efficiency, yet the field still lacks a generalizable CT report generation foundation model that supports multi-region reporting and remains robust across external real-world cohorts. Intrinsic inconsistencies in reporting style and diagnostic terminology across cohorts make naive joint training prone to noisy textual supervision, thereby limiting model generalizability. Here we present Astra, a generalizable CT report generation foundation model trained on 90,678 thoracoabdominal CT-report pairs (CTRgDB) with 353,671 abnormalities spanning eight organ systems. By harmonizing report style and further refining diagnostic consistency via reinforcement learning, Astra achieves style-consistent and diagnostically accurate report generation across diverse anatomical regions and institutions. Evaluating on CTRgDB and six external cohorts, Astra achieves state-of-the-art performance with a 44.1% average improvement in fine-grained diagnostic metrics (P<0.001). In real-world clinical workflows, Astra assistance accelerates chest report drafting by 29.6% and improves abdominal report completeness by 11.3% (P<0.001). Furthermore, Astra also demonstrates broad utility as a foundation for CT AI development, improving downstream diagnostic performance and scaling vision-language pretrain through high-quality report synthesis. Overall, Astra serves as a broadly accessible clinical assistant and a pivotal infrastructure for the next generation of AI-powered healthcare.

Yihua Sun, Qingsong Yao, Yuanyuan Lyu et al.

Digital chest tomosynthesis (DCT) is a technique to produce sectional 3D images of a human chest for pulmonary disease screening, with 2D X-ray projections taken within an extremely limited range of angles. However, under the limited angle scenario, DCT contains strong artifacts caused by the presence of ribs, jamming the imaging quality of the lung area. Recently, great progress has been achieved for rib suppression in a single X-ray image, to reveal a clearer lung texture. We firstly extend the rib suppression problem to the 3D case at the software level. We propose a $\textbf{T}$omosynthesis $\textbf{RI}$b Su$\textbf{P}$pression and $\textbf{L}$ung $\textbf{E}$nhancement $\textbf{Net}$work (TRIPLE-Net) to model the 3D rib component and provide a rib-free DCT. TRIPLE-Net takes the advantages from both 2D and 3D domains, which model the ribs in DCT with the exact FBP procedure and 3D depth information, respectively. The experiments on simulated datasets and clinical data have shown the effectiveness of TRIPLE-Net to preserve lung details as well as improve the imaging quality of pulmonary diseases. Finally, an expert user study confirms our findings.

Jia Guo, Jiawei Du, Shengzhu Yang et al.

Current retinal foundation models remain constrained by curated research datasets that lack authentic clinical context, and require extensive task-specific optimization for each application, limiting their deployment efficiency in low-resource settings. Here, we show that these barriers can be overcome by building clinical native intelligence directly from real-world medical practice. Our key insight is that large-scale telemedicine programs, where expert centers provide remote consultations across distributed facilities, represent a natural reservoir for learning clinical image interpretation. We present ReVision, a retinal foundation model that learns from the natural alignment between 485,980 color fundus photographs and their corresponding diagnostic reports, accumulated through a decade-long telemedicine program spanning 162 medical institutions across China. Through extensive evaluation across 27 ophthalmic benchmarks, we demonstrate that ReVison enables deployment efficiency with minimal local resources. Without any task-specific training, ReVision achieves zero-shot disease detection with an average AUROC of 0.946 across 12 public benchmarks and 0.952 on 3 independent clinical cohorts. When minimal adaptation is feasible, ReVision matches extensively fine-tuned alternatives while requiring orders of magnitude fewer trainable parameters and labeled examples. The learned representations also transfer effectively to new clinical sites, imaging domains, imaging modalities, and systemic health prediction tasks. In a prospective reader study with 33 ophthalmologists, ReVision's zero-shot assistance improved diagnostic accuracy by 14.8% across all experience levels. These results demonstrate that clinical native intelligence can be directly extracted from clinical archives without any further annotation to build medical AI systems suited to various low-resource settings.

Yiran Xu, Haoxiang Zhong, Kai Wu et al.

Object detectors have shown outstanding performance on various public datasets. However, annotating a new dataset for a new task is usually unavoidable in real, since 1) a single existing dataset usually does not contain all object categories needed; 2) using multiple datasets usually suffers from annotation incompletion and heterogeneous features. We propose a novel problem as "Annotation-incomplete Multi-dataset Detection", and develop an end-to-end multi-task learning architecture which can accurately detect all the object categories with multiple partially annotated datasets. Specifically, we propose an attention feature extractor which helps to mine the relations among different datasets. Besides, a knowledge amalgamation training strategy is incorporated to accommodate heterogeneous features from different sources. Extensive experiments on different object detection datasets demonstrate the effectiveness of our methods and an improvement of 2.17%, 2.10% in mAP can be achieved on COCO and VOC respectively.

Zhuhao Wang, Yihua Sun, Zihan Li et al.

Drafting radiology reports is a complex task requiring flexibility, where radiologists tail content to available information and particular clinical demands. However, most current radiology report generation (RRG) models are constrained to a fixed task paradigm, such as predicting the full ``finding'' section from a single image, inherently involving a mismatch between inputs and outputs. The trained models lack the flexibility for diverse inputs and could generate harmful, input-agnostic hallucinations. To bridge the gap between current RRG models and the clinical demands in practice, we first develop a data generation pipeline to create a new MIMIC-RG4 dataset, which considers four common radiology report drafting scenarios and has perfectly corresponded input and output. Secondly, we propose a novel large language model (LLM) based RRG framework, namely LLM-RG4, which utilizes LLM's flexible instruction-following capabilities and extensive general knowledge. We further develop an adaptive token fusion module that offers flexibility to handle diverse scenarios with different input combinations, while minimizing the additional computational burden associated with increased input volumes. Besides, we propose a token-level loss weighting strategy to direct the model's attention towards positive and uncertain descriptions. Experimental results demonstrate that LLM-RG4 achieves state-of-the-art performance in both clinical efficiency and natural language generation on the MIMIC-RG4 and MIMIC-CXR datasets. We quantitatively demonstrate that our model has minimal input-agnostic hallucinations, whereas current open-source models commonly suffer from this problem.

Jiahui Zhang, Dawei Sun, Zixin Luo et al.

Establishing correspondences between two images requires both local and global spatial context. Given putative correspondences of feature points in two views, in this paper, we propose Order-Aware Network, which infers the probabilities of correspondences being inliers and regresses the relative pose encoded by the essential matrix. Specifically, this proposed network is built hierarchically and comprises three novel operations. First, to capture the local context of sparse correspondences, the network clusters unordered input correspondences by learning a soft assignment matrix. These clusters are in a canonical order and invariant to input permutations. Next, the clusters are spatially correlated to form the global context of correspondences. After that, the context-encoded clusters are recovered back to the original size through a proposed upsampling operator. We intensively experiment on both outdoor and indoor datasets. The accuracy of the two-view geometry and correspondences are significantly improved over the state-of-the-arts. Code will be available at https://github.com/zjhthu/OANet.git.

Jiahui Zhang, Hao Zhao, Anbang Yao et al.

We introduce Spatial Group Convolution (SGC) for accelerating the computation of 3D dense prediction tasks. SGC is orthogonal to group convolution, which works on spatial dimensions rather than feature channel dimension. It divides input voxels into different groups, then conducts 3D sparse convolution on these separated groups. As only valid voxels are considered when performing convolution, computation can be significantly reduced with a slight loss of accuracy. The proposed operations are validated on semantic scene completion task, which aims to predict a complete 3D volume with semantic labels from a single depth image. With SGC, we further present an efficient 3D sparse convolutional network, which harnesses a multiscale architecture and a coarse-to-fine prediction strategy. Evaluations are conducted on the SUNCG dataset, achieving state-of-the-art performance and fast speed. Code is available at https://github.com/zjhthu/SGC-Release.git

Jia Guo, Shuai Lu, Weihang Zhang et al.

Recent studies highlighted a practical setting of unsupervised anomaly detection (UAD) that builds a unified model for multi-class images. Despite various advancements addressing this challenging task, the detection performance under the multi-class setting still lags far behind state-of-the-art class-separated models. Our research aims to bridge this substantial performance gap. In this paper, we introduce a minimalistic reconstruction-based anomaly detection framework, namely Dinomaly, which leverages pure Transformer architectures without relying on complex designs, additional modules, or specialized tricks. Given this powerful framework consisted of only Attentions and MLPs, we found four simple components that are essential to multi-class anomaly detection: (1) Foundation Transformers that extracts universal and discriminative features, (2) Noisy Bottleneck where pre-existing Dropouts do all the noise injection tricks, (3) Linear Attention that naturally cannot focus, and (4) Loose Reconstruction that does not force layer-to-layer and point-by-point reconstruction. Extensive experiments are conducted across popular anomaly detection benchmarks including MVTec-AD, VisA, and Real-IAD. Our proposed Dinomaly achieves impressive image-level AUROC of 99.6%, 98.7%, and 89.3% on the three datasets respectively, which is not only superior to state-of-the-art multi-class UAD methods, but also achieves the most advanced class-separated UAD records.

Zongyuan Chen, Yan Xia, Jiayuan Liu et al. · tsinghua

Soft robots exhibit inherent compliance and safety, which makes them particularly suitable for applications requiring direct physical interaction with humans, such as surgical procedures. However, their nonlinear and hysteretic behavior, resulting from the properties of soft materials, presents substantial challenges for accurate modeling and control. In this study, we present a soft robotic system designed for surgical applications and propose a hysteresis-aware whole-body neural network model that accurately captures and predicts the soft robot's whole-body motion, including its hysteretic behavior. Building upon the high-precision dynamic model, we construct a highly parallel simulation environment for soft robot control and apply an on-policy reinforcement learning algorithm to efficiently train whole-body motion control strategies. Based on the trained control policy, we developed a soft robotic system for surgical applications and validated it through phantom-based laser ablation experiments in a physical environment. The results demonstrate that the hysteresis-aware modeling reduces the Mean Squared Error (MSE) by 84.95 percent compared to traditional modeling methods. The deployed control algorithm achieved a trajectory tracking error ranging from 0.126 to 0.250 mm on the real soft robot, highlighting its precision in real-world conditions. The proposed method showed strong performance in phantom-based surgical experiments and demonstrates its potential for complex scenarios, including future real-world clinical applications.

Jia Guo, Shuai Lu, Lei Fan et al.

Unsupervised anomaly detection (UAD) has evolved from building specialized single-class models to unified multi-class models, yet existing multi-class models significantly underperform the most advanced one-for-one counterparts. Moreover, the field has fragmented into specialized methods tailored to specific scenarios (multi-class, 3D, few-shot, etc.), creating deployment barriers and highlighting the need for a unified solution. In this paper, we present Dinomaly2, the first unified framework for full-spectrum image UAD, which bridges the performance gap in multi-class models while seamlessly extending across diverse data modalities and task settings. Guided by the "less is more" philosophy, we demonstrate that the orchestration of five simple element achieves superior performance in a standard reconstruction-based framework. This methodological minimalism enables natural extension across diverse tasks without modification, establishing that simplicity is the foundation of true universality. Extensive experiments on 12 UAD benchmarks demonstrate Dinomaly2's full-spectrum superiority across multiple modalities (2D, multi-view, RGB-3D, RGB-IR), task settings (single-class, multi-class, inference-unified multi-class, few-shot) and application domains (industrial, biological, outdoor). For example, our multi-class model achieves unprecedented 99.9% and 99.3% image-level (I-) AUROC on MVTec-AD and VisA respectively. For multi-view and multi-modal inspection, Dinomaly2 demonstrates state-of-the-art performance with minimum adaptations. Moreover, using only 8 normal examples per class, our method surpasses previous full-shot models, achieving 98.7% and 97.4% I-AUROC on MVTec-AD and VisA. The combination of minimalistic design, computational scalability, and universal applicability positions Dinomaly2 as a unified solution for the full spectrum of real-world anomaly detection applications.

Lingyu Chen, Yawen Zeng, Yue Wang et al.

Conventional single-dataset training often fails with new data distributions, especially in ultrasound (US) image analysis due to limited data, acoustic shadows, and speckle noise. Therefore, constructing a universal framework for multi-heterogeneous US datasets is imperative. However, a key challenge arises: how to effectively mitigate inter-dataset interference while preserving dataset-specific discriminative features for robust downstream task? Previous approaches utilize either a single source-specific decoder or a domain adaptation strategy, but these methods experienced a decline in performance when applied to other domains. Considering this, we propose a Universal Collaborative Mixture of Heterogeneous Source-Specific Experts (COME). Specifically, COME establishes dual structure-semantic shared experts that create a universal representation space and then collaborate with source-specific experts to extract discriminative features through providing complementary features. This design enables robust generalization by leveraging cross-datasets experience distributions and providing universal US priors for small-batch or unseen data scenarios. Extensive experiments under three evaluation modes (single-dataset, intra-organ, and inter-organ integration datasets) demonstrate COME's superiority, achieving significant mean AP improvements over state-of-the-art methods. Our project is available at: https://universalcome.github.io/UniversalCOME/.

Yuanyuan Wang, Yao Zhang, Qiong He et al.

This paper proposes a semi-automatic system based on quantitative characterization of the specific image patterns in lung ultrasound (LUS) images, in order to assess the lung conditions of patients with COVID-19 pneumonia, as well as to differentiate between the severe / and no-severe cases. Specifically, four parameters are extracted from each LUS image, namely the thickness (TPL) and roughness (RPL) of the pleural line, and the accumulated with (AWBL) and acoustic coefficient (ACBL) of B lines. 27 patients are enrolled in this study, which are grouped into 13 moderate patients, 7 severe patients and 7 critical patients. Furthermore, the severe and critical patients are regarded as the severe cases, and the moderate patients are regarded as the non-severe cases. Biomarkers among different groups are compared. Each single biomarker and a classifier with all the biomarkers as input are utilized for the binary diagnosis of severe case and non-severe case, respectively. The classifier achieves the best classification performance among all the compared methods (area under the receiver operating characteristics curve = 0.93, sensitivity = 0.93, specificity = 0.85). The proposed image analysis system could be potentially applied to the grading and prognosis evaluation of patients with COVID-19 pneumonia.

Liutong Zhang, Lei Zhou, Ruiyang Li et al.

Deformable image registration is widely utilized in medical image analysis, but most proposed methods fail in the situation of complex deformations. In this paper, we pre-sent a cascaded feature warping network to perform the coarse-to-fine registration. To achieve this, a shared-weights encoder network is adopted to generate the feature pyramids for the unaligned images. The feature warping registration module is then used to estimate the deformation field at each level. The coarse-to-fine manner is implemented by cascading the module from the bottom level to the top level. Furthermore, the multi-scale loss is also introduced to boost the registration performance. We employ two public benchmark datasets and conduct various experiments to evaluate our method. The results show that our method outperforms the state-of-the-art methods, which also demonstrates that the cascaded feature warping network can perform the coarse-to-fine registration effectively and efficiently.

Bingyu Xin, Yifan Hu, Yefeng Zheng et al.

Magnetic Resonance (MR) images of different modalities can provide complementary information for clinical diagnosis, but whole modalities are often costly to access. Most existing methods only focus on synthesizing missing images between two modalities, which limits their robustness and efficiency when multiple modalities are missing. To address this problem, we propose a multi-modality generative adversarial network (MGAN) to synthesize three high-quality MR modalities (FLAIR, T1 and T1ce) from one MR modality T2 simultaneously. The experimental results show that the quality of the synthesized images by our proposed methods is better than the one synthesized by the baseline model, pix2pix. Besides, for MR brain image synthesis, it is important to preserve the critical tumor information in the generated modalities, so we further introduce a multi-modality tumor consistency loss to MGAN, called TC-MGAN. We use the synthesized modalities by TC-MGAN to boost the tumor segmentation accuracy, and the results demonstrate its effectiveness.

Ke Wang, Han Song, Jiahui Zhang et al.

Sensing the medical scenario can ensure the safety during the surgical operations. So, in this regard, a monitor platform which can obtain the accurate location information of the surgery room is desperately needed. Compared to 2D camera image, 3D data contains more information of distance and direction. Therefore, 3D sensors are more suitable to be used in surgical scene monitoring. However, each 3D sensor has its own limitations. For example, Lidar (Light Detection and Ranging) can detect large-scale environment with high precision, but the point clouds or depth maps are very sparse. As for commodity RGBD sensors, such as Kinect, can accurately capture denser data, but limited to a small range from 0.5 to 4.5m. So, a proper method which can address these problems for fusing different modalities data is important. In this paper, we proposed a method which can fuse different modalities 3D data to get a large-scale and dense point cloud. The key contributions of our work are as follows. First, we proposed a 3D data collecting system to reconstruct the medical scenes. By fusing the Lidar and Kinect data, a large-scale medical scene with more details can be reconstructed. Second, we proposed a location-based fast point clouds registration algorithm to deal with different modality datasets.