Ze Wang

Lei Zhang, Xiaoke Wang, Michael Rawson et al.

Purpose To develop and evaluate a deep learning-based method (MC-Net) to suppress motion artifacts in brain magnetic resonance imaging (MRI). Methods MC-Net was derived from a UNet combined with a two-stage multi-loss function. T1-weighted axial brain images contaminated with synthetic motions were used to train the network. Evaluation used simulated T1 and T2-weighted axial, coronal, and sagittal images unseen during training, as well as T1-weighted images with motion artifacts from real scans. Performance indices included the peak signal to noise ratio (PSNR), structural similarity index measure (SSIM), and visual reading scores. Two clinical readers scored the images. Results The MC-Net outperformed other methods implemented in terms of PSNR and SSIM on the T1 axial test set. The MC-Net significantly improved the quality of all T1-weighted images (for all directions and for simulated as well as real motion artifacts), both on quantitative measures and visual scores. However, the MC-Net performed poorly on images of untrained contrast (T2-weighted). Conclusion The proposed two-stage multi-loss MC-Net can effectively suppress motion artifacts in brain MRI without compromising image context. Given the efficiency of the MC-Net (single image processing time ~40ms), it can potentially be used in real clinical settings. To facilitate further research, the code and trained model are available at https://github.com/MRIMoCo/DL_Motion_Correction.

Yiran Li, Ze Wang

Purpose: Arterial spin labeling (ASL) perfusion imaging indicates direct and absolute measurement of cerebral blood flow (CBF). Arterial transit time (ATT) is a related physiological parameter reflecting the duration for the labeled spins to reach the brain region of interest. Multiple post-labeling delay (PLDs) can provide robust measures of both CBF and ATT, allowing for optimization of regional CBF modeling based on ATT. The prolonged acquisition time can potentially reduce the quality and accuracy of the CBF and ATT estimation. We proposed a novel network to significantly reduce the number of PLDs with higher signal-to-noise ratio (SNR). Method: CBF and ATT estimations were performed for one PLD and two PLDs sepa-rately. Each model was trained independently to learn the nonlinear transformation from perfusion weighted image (PWI) to CBF and ATT images. Results: Both one-PLD and two-PLD models outperformed the conventional method visually on CBF and two-PLD model showed more accurate structure on ATT estima-tion. The proposed method significantly reduces the number of PLDs from 6 to 2 on ATT and even to single PLD on CBF without sacrificing the SNR. Conclusion: It is feasible to generate CBF and ATT maps with reduced PLDs using deep learning with high quality.

Wenjie Liu, Bingshu Wang, Ze Wang et al.

Document shadow removal is a crucial task in the field of document image enhancement. However, existing methods tend to remove shadows with constant color background and ignore color shadows. In this paper, we first design a diffusion model in latent space for document image shadow removal, called DocShaDiffusion. It translates shadow images from pixel space to latent space, enabling the model to more easily capture essential features. To address the issue of color shadows, we design a shadow soft-mask generation module (SSGM). It is able to produce accurate shadow mask and add noise into shadow regions specially. Guided by the shadow mask, a shadow mask-aware guided diffusion module (SMGDM) is proposed to remove shadows from document images by supervising the diffusion and denoising process. We also propose a shadow-robust perceptual feature loss to preserve details and structures in document images. Moreover, we develop a large-scale synthetic document color shadow removal dataset (SDCSRD). It simulates the distribution of realistic color shadows and provides powerful supports for the training of models. Experiments on three public datasets validate the proposed method's superiority over state-of-the-art. Our code and dataset will be publicly available.

Yibo Jin, Yixu Xu, Yue Chen et al.

Serving disaggregated large language models has been widely adopted in industrial practice for enhanced performance. However, too many tokens generated in decoding phase, i.e., occupying the resources for a long time, essentially hamper the cloud from achieving a higher throughput. Meanwhile, due to limited on-device resources, the time to first token (TTFT), i.e., the latency of prefill phase, increases dramatically with the growth on prompt length. In order to concur with such a bottleneck on resources, i.e., long occupation in cloud and limited on-device computing capacity, we propose to separate large language model between cloud and devices. That is, the cloud helps a portion of the content for each device, only in its prefill phase. Specifically, after receiving the first token from the cloud, decoupling with its own prefill, the device responds to the user immediately for a lower TTFT. Then, the following tokens from cloud are presented via a speed controller for smoothed TPOT (the time per output token), until the device catches up with the progress. On-device prefill is then amortized using received tokens while the resource usage in cloud is controlled. Moreover, during cloud prefill, the prompt can be refined, using those intermediate data already generated, to further speed up on-device inference. We implement such a scheme P/D-Device, and confirm its superiority over other alternatives. We further propose an algorithm to decide the best settings. Real-trace experiments show that TTFT decreases at least 60%, maximum TPOT is about tens of milliseconds, and cloud throughput increases by up to 15x.

Danfeng Xie, Yiran Li, Hanlu Yang et al.

Arterial spin labeling (ASL) perfusion MRI provides a non-invasive way to quantify cerebral blood flow (CBF) but it still suffers from a low signal-to-noise-ratio (SNR). Using deep machine learning (DL), several groups have shown encouraging denoising results. Interestingly, the improvement was obtained when the deep neural network was trained using noise-contaminated surrogate reference because of the lack of golden standard high quality ASL CBF images. More strikingly, the output of these DL ASL networks (ASLDN) showed even higher SNR than the surrogate reference. This phenomenon indicates a learning-from-noise capability of deep networks for ASL CBF image denoising, which can be further enhanced by network optimization. In this study, we proposed a new ASLDN to test whether similar or even better ASL CBF image quality can be achieved in the case of highly noisy training reference. Different experiments were performed to validate the learning-from-noise hypothesis. The results showed that the learning-from-noise strategy produced better output quality than ASLDN trained with relatively high SNR reference.

Danfeng Xie, Li Bai, Ze Wang

Arterial spin labeling perfusion MRI is a noninvasive technique for measuring quantitative cerebral blood flow (CBF), but the measurement is subject to a low signal-to-noise-ratio(SNR). Various post-processing methods have been proposed to denoise ASL MRI but only provide moderate improvement. Deep learning (DL) is an emerging technique that can learn the most representative signal from data without prior modeling which can be highly complex and analytically indescribable. The purpose of this study was to assess whether the record breaking performance of DL can be translated into ASL MRI denoising. We used convolutional neural network (CNN) to build the DL ASL denosing model (DL-ASL) to inherently consider the inter-voxel correlations. To better guide DL-ASL training, we incorporated prior knowledge about ASL MRI: the structural similarity between ASL CBF map and grey matter probability map. A relatively large sample data were used to train the model which was subsequently applied to a new set of data for testing. Experimental results showed that DL-ASL achieved state-of-the-art denoising performance for ASL MRI as compared to current routine methods in terms of higher SNR, keeping CBF quantification quality while shorten the acquisition time by 75%, and automatic partial volume correction.