Kang Chen

Aofan Jiang, Chaoqin Huang, Qing Cao et al.

Electrocardiogram (ECG) is a widely used diagnostic tool for detecting heart conditions. Rare cardiac diseases may be underdiagnosed using traditional ECG analysis, considering that no training dataset can exhaust all possible cardiac disorders. This paper proposes using anomaly detection to identify any unhealthy status, with normal ECGs solely for training. However, detecting anomalies in ECG can be challenging due to significant inter-individual differences and anomalies present in both global rhythm and local morphology. To address this challenge, this paper introduces a novel multi-scale cross-restoration framework for ECG anomaly detection and localization that considers both local and global ECG characteristics. The proposed framework employs a two-branch autoencoder to facilitate multi-scale feature learning through a masking and restoration process, with one branch focusing on global features from the entire ECG and the other on local features from heartbeat-level details, mimicking the diagnostic process of cardiologists. Anomalies are identified by their high restoration errors. To evaluate the performance on a large number of individuals, this paper introduces a new challenging benchmark with signal point-level ground truths annotated by experienced cardiologists. The proposed method demonstrates state-of-the-art performance on this benchmark and two other well-known ECG datasets. The benchmark dataset and source code are available at: \url{https://github.com/MediaBrain-SJTU/ECGAD}

Aofan Jiang, Chaoqin Huang, Qing Cao et al.

Current computer-aided ECG diagnostic systems struggle with the underdetection of rare but critical cardiac anomalies due to the imbalanced nature of ECG datasets. This study introduces a novel approach using self-supervised anomaly detection pretraining to address this limitation. The anomaly detection model is specifically designed to detect and localize subtle deviations from normal cardiac patterns, capturing the nuanced details essential for accurate ECG interpretation. Validated on an extensive dataset of over one million ECG records from clinical practice, characterized by a long-tail distribution across 116 distinct categories, the anomaly detection-pretrained ECG diagnostic model has demonstrated a significant improvement in overall accuracy. Notably, our approach yielded a 94.7% AUROC, 92.2% sensitivity, and 92.5\% specificity for rare ECG types, significantly outperforming traditional methods and narrowing the performance gap with common ECG types. The integration of anomaly detection pretraining into ECG analysis represents a substantial contribution to the field, addressing the long-standing challenge of long-tail data distributions in clinical diagnostics. Furthermore, prospective validation in real-world clinical settings revealed that our AI-driven approach enhances diagnostic efficiency, precision, and completeness by 32%, 6.7%, and 11.8% respectively, when compared to standard practices. This advancement marks a pivotal step forward in the integration of AI within clinical cardiology, with particularly profound implications for emergency care, where rapid and accurate ECG interpretation is crucial. The contributions of this study not only push the boundaries of current ECG diagnostic capabilities but also lay the groundwork for more reliable and accessible cardiovascular care.

Gongzheng Tang, Qinghao Zhao, Guangkun Nie et al.

Hyperkalemia is a life-threatening electrolyte disorder that is common in patients with chronic kidney disease and heart failure, yet frequent monitoring remains difficult outside hospital settings. We developed and validated Pocket-K, a single-lead AI-ECG system initialized from the ECGFounder foundation model for non-invasive hyperkalemia screening and handheld deployment. In this multicentre observational study using routinely collected clinical ECG and laboratory data, 34,439 patients contributed 62,290 ECG--potassium pairs. Lead I data were used to fine-tune the model. Data from Peking University People's Hospital were divided into development and temporal validation sets, and data from The Second Hospital of Tianjin Medical University served as an independent external validation set. Hyperkalemia was defined as venous serum potassium > 5.5 mmol/L. Pocket-K achieved AUROCs of 0.936 in internal testing, 0.858 in temporal validation, and 0.808 in external validation. For KDIGO-defined moderate-to-severe hyperkalemia (serum potassium >= 6.0 mmol/L), AUROCs increased to 0.940 and 0.861 in the temporal and external sets, respectively. External negative predictive value exceeded 99.3%. Model-predicted high risk below the hyperkalemia threshold was more common in patients with chronic kidney disease and heart failure. A handheld prototype enabled near-real-time inference, supporting future prospective evaluation in native handheld and wearable settings.

Kang Chen, Shijun Yan, Aiwen Jiang et al.

Bokeh rendering is one of the most popular techniques in photography. It can make photographs visually appealing, forcing users to focus their attentions on particular area of image. However, achieving satisfactory bokeh effect usually presents significant challenge, since mobile cameras with restricted optical systems are constrained, while expensive high-end DSLR lens with large aperture should be needed. Therefore, many deep learning-based computational photography methods have been developed to mimic the bokeh effect in recent years. Nevertheless, most of these methods were limited to rendering bokeh effect in certain single aperture. There lacks user-friendly bokeh rendering method that can provide precise focal plane control and customised bokeh generation. There as well lacks authentic realistic bokeh dataset that can potentially promote bokeh learning on variable apertures. To address these two issues, in this paper, we have proposed an effective controllable bokeh rendering method, and contributed a Variable Aperture Bokeh Dataset (VABD). In the proposed method, user can customize focal plane to accurately locate concerned subjects and select target aperture information for bokeh rendering. Experimental results on public EBB! benchmark dataset and our constructed dataset VABD have demonstrated that the customized focal plane together aperture prompt can bootstrap model to simulate realistic bokeh effect. The proposed method has achieved competitive state-of-the-art performance with only 4.4M parameters, which is much lighter than mainstream computational bokeh models. The contributed dataset and source codes will be released on github https://github.com/MoTong-AI-studio/VABM.

Aofan Jiang, Chaoqin Huang, Qing Cao et al.

The electrocardiogram (ECG) is an essential tool for diagnosing heart disease, with computer-aided systems improving diagnostic accuracy and reducing healthcare costs. Despite advancements, existing systems often miss rare cardiac anomalies that could be precursors to serious, life-threatening issues or alterations in the cardiac macro/microstructure. We address this gap by focusing on self-supervised anomaly detection (AD), training exclusively on normal ECGs to recognize deviations indicating anomalies. We introduce a novel self-supervised learning framework for ECG AD, utilizing a vast dataset of normal ECGs to autonomously detect and localize cardiac anomalies. It proposes a novel masking and restoration technique alongside a multi-scale cross-attention module, enhancing the model's ability to integrate global and local signal features. The framework emphasizes accurate localization of anomalies within ECG signals, ensuring the method's clinical relevance and reliability. To reduce the impact of individual variability, the approach further incorporates crucial patient-specific information from ECG reports, such as age and gender, thus enabling accurate identification of a broad spectrum of cardiac anomalies, including rare ones. Utilizing an extensive dataset of 478,803 ECG graphic reports from real-world clinical practice, our method has demonstrated exceptional effectiveness in AD across all tested conditions, regardless of their frequency of occurrence, significantly outperforming existing models. It achieved superior performance metrics, including an AUROC of 91.2%, an F1 score of 83.7%, a sensitivity rate of 84.2%, a specificity of 83.0%, and a precision of 75.6% with a fixed recall rate of 90%. It has also demonstrated robust localization capabilities, with an AUROC of 76.5% and a Dice coefficient of 65.3% for anomaly localization.