Jianan Li

Jia-Nan Li, Jian Guan, Songhao Wu et al.

Large language models (LLMs) have traditionally been aligned through one-size-fits-all approaches that assume uniform human preferences, fundamentally overlooking the diversity in user values and needs. This paper introduces a comprehensive framework for scalable personalized alignment of LLMs. We establish a systematic preference space characterizing psychological and behavioral dimensions, alongside diverse persona representations for robust preference inference in real-world scenarios. Building upon this foundation, we introduce \textsc{AlignX}, a large-scale dataset of over 1.3 million personalized preference examples, and develop two complementary alignment approaches: \textit{in-context alignment} directly conditioning on persona representations and \textit{preference-bridged alignment} modeling intermediate preference distributions. Extensive experiments demonstrate substantial improvements over existing methods, with an average 17.06\% accuracy gain across four benchmarks while exhibiting a strong adaptation capability to novel preferences, robustness to limited user data, and precise preference controllability. These results validate our approach toward user-adaptive AI systems.

Fang Yan, Jianfeng Wu, Jiawen Li et al.

The complexity and variability inherent in high-resolution pathological images present significant challenges in computational pathology. While pathology foundation models leveraging AI have catalyzed transformative advancements, their development demands large-scale datasets, considerable storage capacity, and substantial computational resources. Furthermore, ensuring their clinical applicability and generalizability requires rigorous validation across a broad spectrum of clinical tasks. Here, we present PathOrchestra, a versatile pathology foundation model trained via self-supervised learning on a dataset comprising 300K pathological slides from 20 tissue and organ types across multiple centers. The model was rigorously evaluated on 112 clinical tasks using a combination of 61 private and 51 public datasets. These tasks encompass digital slide preprocessing, pan-cancer classification, lesion identification, multi-cancer subtype classification, biomarker assessment, gene expression prediction, and the generation of structured reports. PathOrchestra demonstrated exceptional performance across 27,755 WSIs and 9,415,729 ROIs, achieving over 0.950 accuracy in 47 tasks, including pan-cancer classification across various organs, lymphoma subtype diagnosis, and bladder cancer screening. Notably, it is the first model to generate structured reports for high-incidence colorectal cancer and diagnostically complex lymphoma-areas that are infrequently addressed by foundational models but hold immense clinical potential. Overall, PathOrchestra exemplifies the feasibility and efficacy of a large-scale, self-supervised pathology foundation model, validated across a broad range of clinical-grade tasks. Its high accuracy and reduced reliance on extensive data annotation underline its potential for clinical integration, offering a pathway toward more efficient and high-quality medical services.