Jing Jin

Harsh Parikh, Kentaro Hoffman, Haoqi Sun et al.

Epileptiform activity (EA) is associated with worse outcomes including increased risk of disability and death. However, the effect of EA on the neurologic outcome is confounded by the feedback between treatment with anti-seizure medications (ASM) and EA burden. A randomized clinical trial is challenging due to the sequential nature of EA-ASM feedback, as well as ethical reasons. However, some mechanistic knowledge is available, e.g., how drugs are absorbed. This knowledge together with observational data could provide a more accurate effect estimate using causal inference. We performed a retrospective cross-sectional study with 995 patients with the modified Rankin Scale (mRS) at discharge as the outcome and the EA burden defined as the mean or maximum proportion of time spent with EA in six-hour windows in the first 24 hours of electroencephalography as the exposure. We estimated the change in discharge mRS if everyone in the dataset had experienced a certain EA burden and were untreated. We combined pharmacological modeling with an interpretable matching method to account for confounding and EA-ASM feedback. Our matched groups' quality was validated by the neurologists. Having a maximum EA burden greater than 75% when untreated had a 22% increased chance of a poor outcome (severe disability or death), and mild but long-lasting EA increased the risk of a poor outcome by 14%. The effect sizes were heterogeneous depending on pre-admission profile, e.g., patients with hypoxic-ischemic encephalopathy (HIE) or acquired brain injury (ABI) were more affected. Interventions should put a higher priority on patients with an average EA burden higher than 10%, while treatment should be more conservative when the maximum EA burden is low.

Chenyang Shi, Shasha Guo, Boyi Wei et al.

Event cameras are renowned for their high efficiency due to outputting a sparse, asynchronous stream of events. However, they are plagued by noisy events, especially in low light conditions. Denoising is an essential task for event cameras, but evaluating denoising performance is challenging. Label-dependent denoising metrics involve artificially adding noise to clean sequences, complicating evaluations. Moreover, the majority of these metrics are monotonic, which can inflate scores by removing substantial noise and valid events. To overcome these limitations, we propose the first label-free and non-monotonic evaluation metric, the area of the continuous contrast curve (AOCC), which utilizes the area enclosed by event frame contrast curves across different time intervals. This metric is inspired by how events capture the edge contours of scenes or objects with high temporal resolution. An effective denoising method removes noise without eliminating these edge-contour events, thus preserving the contrast of event frames. Consequently, contrast across various time ranges serves as a metric to assess denoising effectiveness. As the time interval lengthens, the curve will initially rise and then fall. The proposed metric is validated through both theoretical and experimental evidence.