Chang Chen

Mingxing Li, Shenglong Zhou, Chang Chen et al.

Accurate retinal vessel segmentation is challenging because of the complex texture of retinal vessels and low imaging contrast. Previous methods generally refine segmentation results by cascading multiple deep networks, which are time-consuming and inefficient. In this paper, we propose two novel methods to address these challenges. First, we devise a light-weight module, named multi-scale residual similarity gathering (MRSG), to generate pixel-wise adaptive filters (PA-Filters). Different from cascading multiple deep networks, only one PA-Filter layer can improve the segmentation results. Second, we introduce a response cue erasing (RCE) strategy to enhance the segmentation accuracy. Experimental results on the DRIVE, CHASE_DB1, and STARE datasets demonstrate that our proposed method outperforms state-of-the-art methods while maintaining a compact structure. Code is available at https://github.com/Limingxing00/Retinal-Vessel-Segmentation-ISBI20222.

Jiancheng Yang, Mingze Gao, Kaiming Kuang et al.

Diagnosis of pulmonary lesions from computed tomography (CT) is important but challenging for clinical decision making in lung cancer related diseases. Deep learning has achieved great success in computer aided diagnosis (CADx) area for lung cancer, whereas it suffers from label ambiguity due to the difficulty in the radiological diagnosis. Considering that invasive pathological analysis serves as the clinical golden standard of lung cancer diagnosis, in this study, we solve the label ambiguity issue via a large-scale radio-pathomics dataset containing 5,134 radiological CT images with pathologically confirmed labels, including cancers (e.g., invasive/non-invasive adenocarcinoma, squamous carcinoma) and non-cancer diseases (e.g., tuberculosis, hamartoma). This retrospective dataset, named Pulmonary-RadPath, enables development and validation of accurate deep learning systems to predict invasive pathological labels with a non-invasive procedure, i.e., radiological CT scans. A three-level hierarchical classification system for pulmonary lesions is developed, which covers most diseases in cancer-related diagnosis. We explore several techniques for hierarchical classification on this dataset, and propose a Leaky Dense Hierarchy approach with proven effectiveness in experiments. Our study significantly outperforms prior arts in terms of data scales (6x larger), disease comprehensiveness and hierarchies. The promising results suggest the potentials to facilitate precision medicine.