Chunyan Wang

Juncheng Tong, Chunyan Wang

The research on developing CNN-based fully-automated Brain-Tumor-Segmentation systems has been progressed rapidly. For the systems to be applicable in practice, a good The research on developing CNN-based fully-automated Brain-Tumor-Segmentation systems has been progressed rapidly. For the systems to be applicable in practice, a good processing quality and reliability are the must. Moreover, for wide applications of such systems, a minimization of computation complexity is desirable, which can also result in a minimization of randomness in computation and, consequently, a better performance consistency. To this end, the CNN in the proposed system has a unique structure with 2 distinguished characters. Firstly, the three paths of its feature extraction block are designed to extract, from the multi-modality input, comprehensive feature information of mono-modality, paired-modality and cross-modality data, respectively. Also, it has a particular three-branch classification block to identify the pixels of 4 classes. Each branch is trained separately so that the parameters are updated specifically with the corresponding ground truth data of a target tumor areas. The convolution layers of the system are custom-designed with specific purposes, resulting in a very simple config of 61,843 parameters in total. The proposed system is tested extensively with BraTS2018 and BraTS2019 datasets. The mean Dice scores, obtained from the ten experiments on BraTS2018 validation samples, are 0.787+0.003, 0.886+0.002, 0.801+0.007, for enhancing tumor, whole tumor and tumor core, respectively, and 0.751+0.007, 0.885+0.002, 0.776+0.004 on BraTS2019. The test results demonstrate that the proposed system is able to perform high-quality segmentation in a consistent manner. Furthermore, its extremely low computation complexity will facilitate its implementation/application in various environments.

Yanming Sun, Chunyan Wang

The work presented in this paper is to propose a reliable high-quality system of Convolutional Neural Network (CNN) for brain tumor segmentation with a low computation requirement. The system consists of a CNN for the main processing for the segmentation, a pre-CNN block for data reduction and post-CNN refinement block. The unique CNN consists of 7 convolution layers involving only 108 kernels and 20308 trainable parameters. It is custom-designed, following the proposed paradigm of ASCNN (application specific CNN), to perform mono-modality and cross-modality feature extraction, tumor localization and pixel classification. Each layer fits the task assigned to it, by means of (i) appropriate normalization applied to its input data, (ii) correct convolution modes for the assigned task, and (iii) suitable nonlinear transformation to optimize the convolution results. In this specific design context, the number of kernels in each of the 7 layers is made to be just-sufficient for its task, instead of exponentially growing over the layers, to increase information density and to reduce randomness in the processing. The proposed activation function Full-ReLU helps to halve the number of kernels in convolution layers of high-pass filtering without degrading processing quality. A large number of experiments with BRATS2018 dataset have been conducted to measure the processing quality and reproducibility of the proposed system. The results demonstrate that the system reproduces reliably almost the same output to the same input after retraining. The mean dice scores for enhancing tumor, whole tumor and tumor core are 77.2%, 89.2% and 76.3%, respectively. The simple structure and reliable high processing quality of the proposed system will facilitate its implementation and medical applications.