Ying Yu

Cui Long, Yongbin Liu, Chunping Ouyang et al.

Large Language Models (LLMs) have exhibited remarkable proficiency in natural language understanding, prompting extensive exploration of their potential applications across diverse domains. In the medical domain, open-source LLMs have demonstrated moderate efficacy following domain-specific fine-tuning; however, they remain substantially inferior to proprietary models such as GPT-4 and GPT-3.5. These open-source models encounter limitations in the comprehensiveness of domain-specific knowledge and exhibit a propensity for 'hallucinations' during text generation. To mitigate these issues, researchers have implemented the Retrieval-Augmented Generation (RAG) approach, which augments LLMs with background information from external knowledge bases while preserving the model's internal parameters. However, document noise can adversely affect performance, and the application of RAG in the medical field remains in its nascent stages. This study presents the Bailicai framework: a novel integration of retrieval-augmented generation with large language models optimized for the medical domain. The Bailicai framework augments the performance of LLMs in medicine through the implementation of four sub-modules. Experimental results demonstrate that the Bailicai approach surpasses existing medical domain LLMs across multiple medical benchmarks and exceeds the performance of GPT-3.5. Furthermore, the Bailicai method effectively attenuates the prevalent issue of hallucinations in medical applications of LLMs and ameliorates the noise-related challenges associated with traditional RAG techniques when processing irrelevant or pseudo-relevant documents.

Yifan Wu, Min Zeng, Ying Yu et al.

Automatic International Classification of Diseases (ICD) coding is defined as a kind of text multi-label classification problem, which is difficult because the number of labels is very large and the distribution of labels is unbalanced. The label-wise attention mechanism is widely used in automatic ICD coding because it can assign weights to every word in full Electronic Medical Records (EMR) for different ICD codes. However, the label-wise attention mechanism is computational redundant and costly. In this paper, we propose a pseudo label-wise attention mechanism to tackle the problem. Instead of computing different attention modes for different ICD codes, the pseudo label-wise attention mechanism automatically merges similar ICD codes and computes only one attention mode for the similar ICD codes, which greatly compresses the number of attention modes and improves the predicted accuracy. In addition, we apply a more convenient and effective way to obtain the ICD vectors, and thus our model can predict new ICD codes by calculating the similarities between EMR vectors and ICD vectors. Extensive experiments show the superior performance of our model. On the public MIMIC-III dataset and private Xiangya dataset, our model achieves micro f1 of 0.583 and 0.806, respectively, which outperforms other competing models. Furthermore, we verify the ability of our model in predicting new ICD codes. The case study shows how pseudo label-wise attention works, and demonstrates the effectiveness of pseudo label-wise attention mechanism.