Yue Chen

Yupei Zhang, Xianjin Dai, Zhen Tian et al.

This study proposed a deep learning-based tracking method for ultrasound (US) image-guided radiation therapy. The proposed cascade deep learning model is composed of an attention network, a mask region-based convolutional neural network (mask R-CNN), and a long short-term memory (LSTM) network. The attention network learns a mapping from a US image to a suspected area of landmark motion in order to reduce the search region. The mask R-CNN then produces multiple region-of-interest (ROI) proposals in the reduced region and identifies the proposed landmark via three network heads: bounding box regression, proposal classification, and landmark segmentation. The LSTM network models the temporal relationship among the successive image frames for bounding box regression and proposal classification. To consolidate the final proposal, a selection method is designed according to the similarities between sequential frames. The proposed method was tested on the liver US tracking datasets used in the Medical Image Computing and Computer Assisted Interventions (MICCAI) 2015 challenges, where the landmarks were annotated by three experienced observers to obtain their mean positions. Five-fold cross-validation on the 24 given US sequences with ground truths shows that the mean tracking error for all landmarks is 0.65+/-0.56 mm, and the errors of all landmarks are within 2 mm. We further tested the proposed model on 69 landmarks from the testing dataset that has a similar image pattern to the training pattern, resulting in a mean tracking error of 0.94+/-0.83 mm. Our experimental results have demonstrated the feasibility and accuracy of our proposed method in tracking liver anatomic landmarks using US images, providing a potential solution for real-time liver tracking for active motion management during radiation therapy.

Pradyumna YM, Yuxuan Xue, Yue Chen et al.

Reconstructing physically plausible 3D human-scene interactions (HSI) from a single image currently presents a trade-off: optimization based methods offer accurate contact but are slow (~20s), while feed-forward approaches are fast yet lack explicit interaction reasoning, producing floating and interpenetration artifacts. Our key insight is that geometry-based human--scene fitting can be amortized into fast feed-forward inference. We present GRAFT (Geometric Refinement And Fitting Transformer), a learned HSI prior that predicts Interaction Gradients: corrective parameter updates that iteratively refine human meshes by reasoning about their 3D relationship to the surrounding scene. GRAFT encodes the interaction state into compact body-anchored tokens, each grounded in the scene geometry via Geometric Probes that capture spatial relationships with nearby surfaces. A lightweight transformer recurrently updates human meshes and re-probes the scene, ensuring the final pose aligns with both learned priors and observed geometry. GRAFT operates either as an end-to-end reconstructor using image features, or with geometry alone as a transferable plug-and-play HSI prior that improves feed-forward methods without retraining. Experiments show GRAFT improves interaction quality by up to 113% over state-of-the-art feed-forward methods and matches optimization-based interaction quality at ${\sim}50{\times}$ lower runtime, while generalizing seamlessly to in-the-wild multi-person scenes and being preferred in 64.8% of three-way user study. Project page: https://pradyumnaym.github.io/graft .

Yucun Hou, Fenglin Zhan, Chenxi Li et al.

Deep learning-based reconstruction of positron emission tomography(PET) data has gained increasing attention in recent years. While these methods achieve fast reconstruction,concerns remain regarding quantitative accuracy and the presence of artifacts,stemming from limited model interpretability,data driven dependence, and overfitting risks.These challenges have hindered clinical adoption.To address them,we propose a conditional diffusion model with posterior physical correction (PET-DPC) for PET image reconstruction. An innovative normalization procedure generates the input Geometric TOF Probabilistic Image (GTP-image),while physical information is incorporated during the diffusion sampling process to perform posterior scatter,attenuation,and random corrections. The model was trained and validated on 300 brain and 50 whole-body PET datasets,a physical phantom,and 20 simulated brain datasets. PET-DPC produced reconstructions closely aligned with fully corrected OSEM images,outperforming end-to-end deep learning models in quantitative metrics and,in some cases, surpassing traditional iterative methods. The model also generalized well to out-of-distribution(OOD) data. Compared to iterative methods,PET-DPC reduced reconstruction time by 50% for brain scans and 85% for whole-body scans. Ablation studies confirmed the critical role of posterior correction in implementing scatter and attenuation corrections,enhancing reconstruction accuracy. Experiments with physical phantoms further demonstrated PET-DPC's ability to preserve background uniformity and accurately reproduce tumor-to-background intensity ratios. Overall,these results highlight PET-DPC as a promising approach for rapid, quantitatively accurate PET reconstruction,with strong potential to improve clinical imaging workflows.