Tingting Chen

Zhengbang Zhu, Hanye Zhao, Haoran He et al.

Diffusion models surpass previous generative models in sample quality and training stability. Recent works have shown the advantages of diffusion models in improving reinforcement learning (RL) solutions. This survey aims to provide an overview of this emerging field and hopes to inspire new avenues of research. First, we examine several challenges encountered by RL algorithms. Then, we present a taxonomy of existing methods based on the roles of diffusion models in RL and explore how the preceding challenges are addressed. We further outline successful applications of diffusion models in various RL-related tasks. Finally, we conclude the survey and offer insights into future research directions. We are actively maintaining a GitHub repository for papers and other related resources in utilizing diffusion models in RL: https://github.com/apexrl/Diff4RLSurvey.

Jinhong Wang, Yi Cheng, Jintai Chen et al.

Ordinal regression refers to classifying object instances into ordinal categories. It has been widely studied in many scenarios, such as medical disease grading, movie rating, etc. Known methods focused only on learning inter-class ordinal relationships, but still incur limitations in distinguishing adjacent categories thus far. In this paper, we propose a simple sequence prediction framework for ordinal regression called Ord2Seq, which, for the first time, transforms each ordinal category label into a special label sequence and thus regards an ordinal regression task as a sequence prediction process. In this way, we decompose an ordinal regression task into a series of recursive binary classification steps, so as to subtly distinguish adjacent categories. Comprehensive experiments show the effectiveness of distinguishing adjacent categories for performance improvement and our new approach exceeds state-of-the-art performances in four different scenarios. Codes are available at https://github.com/wjh892521292/Ord2Seq.

Jinhong Wang, Jingwen Wang, Tingting Chen et al.

Surgery is the only viable treatment for cataract patients with visual acuity (VA) impairment. Clinically, to assess the necessity of cataract surgery, accurately predicting postoperative VA before surgery by analyzing multi-view optical coherence tomography (OCT) images is crucially needed. Unfortunately, due to complicated fundus conditions, determining postoperative VA remains difficult for medical experts. Deep learning methods for this problem were developed in recent years. Although effective, these methods still face several issues, such as not efficiently exploring potential relations between multi-view OCT images, neglecting the key role of clinical prior knowledge (e.g., preoperative VA value), and using only regression-based metrics which are lacking reference. In this paper, we propose a novel Cross-token Transformer Network (CTT-Net) for postoperative VA prediction by analyzing both the multi-view OCT images and preoperative VA. To effectively fuse multi-view features of OCT images, we develop cross-token attention that could restrict redundant/unnecessary attention flow. Further, we utilize the preoperative VA value to provide more information for postoperative VA prediction and facilitate fusion between views. Moreover, we design an auxiliary classification loss to improve model performance and assess VA recovery more sufficiently, avoiding the limitation by only using the regression metrics. To evaluate CTT-Net, we build a multi-view OCT image dataset collected from our collaborative hospital. A set of extensive experiments validate the effectiveness of our model compared to existing methods in various metrics. Code is available at: https://github.com/wjh892521292/Cataract OCT.

Qiran Zou, Hou Hei Lam, Wenhao Zhao et al.

AI research agents accelerate ML research by automating hypothesis generation, experimentation, and empirical refinement. Existing agent strategies range from greedy hill-climbing to tree search and evolutionary optimization, yet which strategy choices drive performance remains unclear. Answering this question requires a benchmark that separates agent strategy (e.g., search topology) from execution infrastructure (e.g., code editor), so that performance differences are attributable to strategy rather than infrastructure, and that provides process-level metrics beyond final scores to analyze exploration behaviors. Existing benchmarks offer limited support. We propose FML-Bench, a benchmark of 18 fundamental ML research tasks across 10 domains that separates agent strategy from execution infrastructure and defines 12 process-level behavioral metrics. Evaluating six representative agents, we find that: (1) strategy complexity alone does not guarantee strong performance: a simple greedy hill-climber nearly matches the best-performing tree-search agent, both well above the remaining agents; (2) our analysis suggests this pattern relates to improvement opportunity structure: greedy search tends to be more effective when opportunities are dense, while tree-search and evolutionary strategies tend to be more effective when opportunities are sparse; an adaptive agent built on this insight switches to broader exploration upon detecting improvement stagnation and outperforms the other six agents, lending initial support to this observation; and (3) process-level analysis reveals that early convergence and directionally focused exploration are significantly associated with final performance, while solution diversity and compute cost are not. Our benchmark is available at: https://github.com/qrzou/FML-bench.

Wanjun Du, Zifeng Yuan, Tingting Chen et al.

Existing vision-language models (VLMs) have demonstrated impressive performance in reasoning-based segmentation. However, current benchmarks are primarily constructed from high-quality images captured under idealized conditions. This raises a critical question: when visual cues are severely degraded by adverse weather conditions such as rain, snow, or fog, can VLMs sustain reliable reasoning segmentation capabilities? In response to this challenge, we introduce WeatherReasonSeg, a benchmark designed to evaluate VLM performance in reasoning-based segmentation under adverse weather conditions. It consists of two complementary components. First, we construct a controllable reasoning dataset by applying synthetic weather with varying severity levels to existing segmentation datasets, enabling fine-grained robustness analysis. Second, to capture real-world complexity, we curate a real-world adverse-weather reasoning segmentation dataset with semantically consistent queries generated via mask-guided LLM prompting. We further broaden the evaluation scope across five reasoning dimensions, including functionality, application scenarios, structural attributes, interactions, and requirement matching. Extensive experiments across diverse VLMs reveal two key findings: (1) VLM performance degrades monotonically with increasing weather severity, and (2) different weather types induce distinct vulnerability patterns. We hope WeatherReasonSeg will serve as a foundation for advancing robust, weather-aware reasoning.

Jinhong Wang, Tingting Chen, Jintai Chen et al.

Automatic ophthalmic disease diagnosis on fundus images is important in clinical practice. However, due to complex fundus textures and limited annotated data, developing an effective automatic method for this problem is still challenging. In this paper, we present a self-supervised method via polar transformation based progressive contrastive learning, called PoCo, for ophthalmic disease diagnosis. Specifically, we novelly inject the polar transformation into contrastive learning to 1) promote contrastive learning pre-training to be faster and more stable and 2) naturally capture task-free and rotation-related textures, which provides insights into disease recognition on fundus images. Beneficially, simple normal translation-invariant convolution on transformed images can equivalently replace the complex rotation-invariant and sector convolution on raw images. After that, we develop a progressive contrastive learning method to efficiently utilize large unannotated images and a novel progressive hard negative sampling scheme to gradually reduce the negative sample number for efficient training and performance enhancement. Extensive experiments on three public ophthalmic disease datasets show that our PoCo achieves state-of-the-art performance with good generalization ability, validating that our method can reduce annotation efforts and provide reliable diagnosis. Codes are available at \url{https://github.com/wjh892521292/PoCo}.

Tingting Chen, Beibei Lin, Zifeng Yuan et al.

As language models are increasingly used in scientific workflows, evaluating their ability to propose sets of explanations-not just a single correct answer-becomes critical. Many scientific problems are underdetermined: multiple, mechanistically distinct hypotheses are consistent with the same observations. We introduce HypoSpace, a diagnostic suite that treats LLMs as samplers of finite hypothesis sets and measures three complementary indicators: Validity (precision of proposals consistent with observations), Uniqueness (non-redundancy among proposals), and Recovery (coverage of the enumerated admissible set). We instantiate HypoSpace in three structured domains with deterministic validators and exactly enumerated hypothesis spaces: (i) causal graphs from perturbations, (ii) gravity-constrained 3D voxel reconstruction from top-down projections, and (iii) Boolean genetic interactions. Across instruction-tuned and reasoning-focused models, Validity often remains high while Uniqueness and Recovery degrade as the admissible space grows, revealing mode collapse that is invisible to correctness-only metrics. HypoSpace offers a controlled probe-rather than a leaderboard-for methods that explicitly explore and cover admissible explanation spaces. Code is available at: https://github.com/CTT-Pavilion/_HypoSpace.

Qiran Zou, Hou Hei Lam, Wenhao Zhao et al.

Large language models (LLMs) have sparked growing interest in automatic machine learning research agents. Among them, agents capable of autonomously proposing ideas and conducting machine learning experiments are particularly promising, as they maximize research automation and accelerate scientific progress by iteratively refining ideas based on experimental results. However, comprehensively evaluating such agents remains challenging. Existing benchmarks tend to overemphasize engineering aspects while neglecting academic rigor, creating barriers that obscure a clear assessment of an agent's scientific capabilities in machine learning research. They also suffer from limited task diversity, an overemphasis on application-oriented tasks over fundamental research problems, and limited scalability to realistic research settings. To address these limitations, we introduce FML-bench, a benchmark designed to evaluate automatic machine learning research agents on 8 diverse and fundamental machine learning research problems. It reduces coding burden, emphasizes fundamental problems rather than specific use cases, offers high task diversity, and is extensible to real-world machine learning GitHub repositories. Furthermore, we present a unified evaluation framework with five complementary metrics, designed to comprehensively assess agent performance on our benchmark. We evaluate state-of-the-art automatic research agents on FML-bench, and find that agents employing broad research exploration strategies outperform those focusing on narrow but deep exploration. These findings suggest that emphasizing the breadth of exploration may lead to more effective research outcomes than focusing solely on incremental refinement. Our benchmark is available at https://github.com/qrzou/FML-bench.

Yihao Liu, Xu Cao, Tingting Chen et al.

Healthcare systems worldwide face persistent challenges in efficiency, accessibility, and personalization. Powered by modern AI technologies such as multimodal large language models and world models, Embodied AI (EmAI) represents a transformative frontier, offering enhanced autonomy and the ability to interact with the physical world to address these challenges. As an interdisciplinary and rapidly evolving research domain, "EmAI in healthcare" spans diverse fields such as algorithms, robotics, and biomedicine. This complexity underscores the importance of timely reviews and analyses to track advancements, address challenges, and foster cross-disciplinary collaboration. In this paper, we provide a comprehensive overview of the "brain" of EmAI for healthcare, wherein we introduce foundational AI algorithms for perception, actuation, planning, and memory, and focus on presenting the healthcare applications spanning clinical interventions, daily care & companionship, infrastructure support, and biomedical research. Despite its promise, the development of EmAI for healthcare is hindered by critical challenges such as safety concerns, gaps between simulation platforms and real-world applications, the absence of standardized benchmarks, and uneven progress across interdisciplinary domains. We discuss the technical barriers and explore ethical considerations, offering a forward-looking perspective on the future of EmAI in healthcare. A hierarchical framework of intelligent levels for EmAI systems is also introduced to guide further development. By providing systematic insights, this work aims to inspire innovation and practical applications, paving the way for a new era of intelligent, patient-centered healthcare.

Tingting Chen, Srinivas Anumasa, Beibei Lin et al.

Given the remarkable performance of Large Language Models (LLMs), an important question arises: Can LLMs conduct human-like scientific research and discover new knowledge, and act as an AI scientist? Scientific discovery is an iterative process that demands efficient knowledge updating and encoding. It involves understanding the environment, identifying new hypotheses, and reasoning about actions; however, no standardized benchmark specifically designed for scientific discovery exists for LLM agents. In response to these limitations, we introduce a novel benchmark, \textit{Auto-Bench}, that encompasses necessary aspects to evaluate LLMs for scientific discovery in both natural and social sciences. Our benchmark is based on the principles of causal graph discovery. It challenges models to uncover hidden structures and make optimal decisions, which includes generating valid justifications. By engaging interactively with an oracle, the models iteratively refine their understanding of underlying interactions, the chemistry and social interactions, through strategic interventions. We evaluate state-of-the-art LLMs, including GPT-4, Gemini, Qwen, Claude, and Llama, and observe a significant performance drop as the problem complexity increases, which suggests an important gap between machine and human intelligence that future development of LLMs need to take into consideration.

Beibei Lin, Tingting Chen, Robby T. Tan

Reference-driven image completion, which restores missing regions in a target view using additional images, is particularly challenging when the target view differs significantly from the references. Existing generative methods rely solely on diffusion priors and, without geometric cues such as camera pose or depth, often produce misaligned or implausible content. We propose GeoComplete, a novel framework that incorporates explicit 3D structural guidance to enforce geometric consistency in the completed regions, setting it apart from prior image-only approaches. GeoComplete introduces two key ideas: conditioning the diffusion process on projected point clouds to infuse geometric information, and applying target-aware masking to guide the model toward relevant reference cues. The framework features a dual-branch diffusion architecture. One branch synthesizes the missing regions from the masked target, while the other extracts geometric features from the projected point cloud. Joint self-attention across branches ensures coherent and accurate completion. To address regions visible in references but absent in the target, we project the target view into each reference to detect occluded areas, which are then masked during training. This target-aware masking directs the model to focus on useful cues, enhancing performance in difficult scenarios. By integrating a geometry-aware dual-branch diffusion architecture with a target-aware masking strategy, GeoComplete offers a unified and robust solution for geometry-conditioned image completion. Experiments show that GeoComplete achieves a 17.1 PSNR improvement over state-of-the-art methods, significantly boosting geometric accuracy while maintaining high visual quality.

Beibei Lin, Zifeng Yuan, Tingting Chen

Polarization images provide rich physical information that is fundamentally absent from standard RGB images, benefiting a wide range of computer vision applications such as reflection separation and material classification. However, the acquisition of polarization images typically requires additional optical components, which increases both the cost and the complexity of the applications. To bridge this gap, we introduce a new task: RGB-to-polarization image estimation, which aims to infer polarization information directly from RGB images. In this work, we establish the first comprehensive benchmark for this task by leveraging existing polarization datasets and evaluating a diverse set of state-of-the-art deep learning models, including both restoration-oriented and generative architectures. Through extensive quantitative and qualitative analysis, our benchmark not only establishes the current performance ceiling of RGB-to-polarization estimation, but also systematically reveals the respective strengths and limitations of different model families -- such as direct reconstruction versus generative synthesis, and task-specific training versus large-scale pre-training. In addition, we provide some potential directions for future research on polarization estimation. This benchmark is intended to serve as a foundational resource to facilitate the design and evaluation of future methods for polarization estimation from standard RGB inputs.

Hongyu He, Shaowen Xiang, Ye Zhang et al.

Generative artificial intelligence (AI) is rapidly populating medical records with synthetic content, creating a feedback loop where future models are increasingly at risk of training on uncurated AI-generated data. However, the clinical consequences of this AI-generated data contamination remain unexplored. Here, we show that in the absence of mandatory human verification, this self-referential cycle drives a rapid erosion of pathological variability and diagnostic reliability. By analysing more than 800,000 synthetic data points across clinical text generation, vision-language reporting, and medical image synthesis, we find that models progressively converge toward generic phenotypes regardless of the model architecture. Specifically, rare but critical findings, including pneumothorax and effusions, vanish from the synthetic content generated by AI models, while demographic representations skew heavily toward middle-aged male phenotypes. Crucially, this degradation is masked by false diagnostic confidence; models continue to issue reassuring reports while failing to detect life-threatening pathology, with false reassurance rates tripling to 40%. Blinded physician evaluation confirms that this decoupling of confidence and accuracy renders AI-generated documentation clinically useless after just two generations. We systematically evaluate three mitigation strategies, finding that while synthetic volume scaling fails to prevent collapse, mixing real data with quality-aware filtering effectively preserves diversity. Ultimately, our results suggest that without policy-mandated human oversight, the deployment of generative AI threatens to degrade the very healthcare data ecosystems it relies upon.

Tingting Chen, Feng Chu, Jiantong Zhang

Service region design determines the geographic coverage of service networks, shaping long-term operational performance. Capital and operational constraints preclude simultaneous large-scale deployment, requiring expansion to proceed sequentially. The resulting challenge is to determine when and where to invest under demand uncertainty, balancing intertemporal trade-offs between early and delayed investment and accounting for network effects whereby each deployment reshapes future demand through inter-regional connectivity. This study addresses a sequential service region design (SSRD) problem incorporating two practical yet underexplored factors: a $k$-region constraint that limits the number of regions investable per period and a stochastic spillover effect linking investment decisions to demand evolution. The resulting problem requires sequencing regional portfolios under uncertainty, leading to a combinatorial explosion in feasible investment sequences. To address this challenge, we propose a solution framework that integrates real options analysis (ROA) with a Transformer-based Proximal Policy Optimization (TPPO) algorithm. ROA evaluates the intertemporal option value of investment sequences, while TPPO learns sequential policies that directly generate high option-value sequences without exhaustive enumeration. Numerical experiments on realistic multi-region settings demonstrate that TPPO converges faster than benchmark DRL methods and consistently identifies sequences with superior option value. Case studies and sensitivity analyses further confirm robustness and provide insights on investment concurrency, regional prioritization, and the increasing benefits of adaptive expansion via our approach under stronger spillovers and dynamic market conditions.

Zhiqiang Teng, Beibei Lin, Tingting Chen et al.

3D Gaussian Splatting (3DGS) under raindrop conditions suffers from severe occlusions and optical distortions caused by raindrop contamination on the camera lens, substantially degrading reconstruction quality. Existing benchmarks typically evaluate 3DGS using synthetic raindrop images with known camera poses (constrained images), assuming ideal conditions. However, in real-world scenarios, raindrops often interfere with accurate camera pose estimation and point cloud initialization. Moreover, a significant domain gap between synthetic and real raindrops further impairs generalization. To tackle these issues, we introduce RaindropGS, a comprehensive benchmark designed to evaluate the full 3DGS pipeline-from unconstrained, raindrop-corrupted images to clear 3DGS reconstructions. Specifically, the whole benchmark pipeline consists of three parts: data preparation, data processing, and raindrop-aware 3DGS evaluation, including types of raindrop interference, camera pose estimation and point cloud initialization, single image rain removal comparison, and 3D Gaussian training comparison. First, we collect a real-world raindrop reconstruction dataset, in which each scene contains three aligned image sets: raindrop-focused, background-focused, and rain-free ground truth, enabling a comprehensive evaluation of reconstruction quality under different focus conditions. Through comprehensive experiments and analyses, we reveal critical insights into the performance limitations of existing 3DGS methods on unconstrained raindrop images and the varying impact of different pipeline components: the impact of camera focus position on 3DGS reconstruction performance, and the interference caused by inaccurate pose and point cloud initialization on reconstruction. These insights establish clear directions for developing more robust 3DGS methods under raindrop conditions.

Srinivas Anumasa, Barath Chandran. C, Tingting Chen et al.

Diffusion models have emerged as a powerful class of generative models by learning to iteratively reverse the noising process. Their ability to generate high-quality samples has extended beyond high-dimensional image data to other complex domains such as proteins, where data distributions are typically sparse and unevenly spread. Importantly, the sparsity itself is uneven. Empirically, we observed that while a small fraction of samples lie in dense clusters, the majority occupy regions of varying sparsity across the data space. Existing approaches largely ignore this data-dependent variability. In this work, we introduce a Data-Dependent Smoothing Walk-Jump framework that employs kernel density estimation (KDE) as a preprocessing step to estimate the noise scale $σ$ for each data point, followed by training a score model with these data-dependent $σ$ values. By incorporating local data geometry into the denoising process, our method accounts for the heterogeneous distribution of protein data. Empirical evaluations demonstrate that our approach yields consistent improvements across multiple metrics, highlighting the importance of data-aware sigma prediction for generative modeling in sparse, high-dimensional settings.

Eitan Rothberg, Tingting Chen, Luo Jie et al.

Today's state-of-the-art image classifiers fail to correctly classify carefully manipulated adversarial images. In this work, we develop a new, localized adversarial attack that generates adversarial examples by imperceptibly altering the backgrounds of normal images. We first use this attack to highlight the unnecessary sensitivity of neural networks to changes in the background of an image, then use it as part of a new training technique: localized adversarial training. By including locally adversarial images in the training set, we are able to create a classifier that suffers less loss than a non-adversarially trained counterpart model on both natural and adversarial inputs. The evaluation of our localized adversarial training algorithm on MNIST and CIFAR-10 datasets shows decreased accuracy loss on natural images, and increased robustness against adversarial inputs.

Jie Liu, Tingting Chen, Guilin Wen et al.

Pyramidal lattice sandwich structure (PLSS) exhibits high stiffness and strength-to-weight ratio which can be effectively utilized for designing light-weight load bearing structures for ranging from ground to aerospace vehicles. While these structures provide superior strength to weigh ratio, their sound insulation capacity has not been well understood. The aim of this study is to develop numerical and experimental methods to fundamentally investigate the sound insulation property of the pyramidal lattice sandwich structure with solid trusses (PLSSST). A finite element model has been developed to predict the sound transmission loss (STL) of PLSSST and simulation results have been compared with those obtained experimentally. Parametric studies is then performed using the validated finite element model to investigate the effect of different parameters in pyramidal lattice sandwich structure with hollow trusses (PLSSHT), revealing that the pitching angle, the uniform thickness and the length of the hollow truss and the lattice constant have considerable effects on the sound transmission loss. Finally a design optimization strategy has been formulated to optimize PLSSHT in order to maximize STL while meeting mechanical property requirements. It has been shown that STL of the optimal PLSSHT can be increased by almost 10% at the low-frequency band. The work reported here provides useful information for the noise reduction design of periodic lattice structures.