Pan Li

Li Pan, Yupei Zhang, Qiushi Yang et al.

Recently, multimodal deep learning, which integrates histopathology slides and molecular biomarkers, has achieved a promising performance in glioma grading. Despite great progress, due to the intra-modality complexity and inter-modality heterogeneity, existing studies suffer from inadequate histopathology representation learning and inefficient molecular-pathology knowledge alignment. These two issues hinder existing methods to precisely interpret diagnostic molecular-pathology features, thereby limiting their grading performance. Moreover, the real-world applicability of existing multimodal approaches is significantly restricted as molecular biomarkers are not always available during clinical deployment. To address these problems, we introduce a novel Focus on Focus (FoF) framework with paired pathology-genomic training and applicable pathology-only inference, enhancing molecular-pathology representation effectively. Specifically, we propose a Focus-oriented Representation Learning (FRL) module to encourage the model to identify regions positively or negatively related to glioma grading and guide it to focus on the diagnostic areas with a consistency constraint. To effectively link the molecular biomarkers to morphological features, we propose a Multi-view Cross-modal Alignment (MCA) module that projects histopathology representations into molecular subspaces, aligning morphological features with corresponding molecular biomarker status by supervised contrastive learning. Experiments on the TCGA GBM-LGG dataset demonstrate that our FoF framework significantly improves the glioma grading. Remarkably, our FoF achieves superior performance using only histopathology slides compared to existing multimodal methods. The source code is available at https://github.com/peterlipan/FoF.

Yuyan Wang, Pan Li, Minmin Chen

Recommender systems are central to digital platforms, yet they face a fundamental trade-off between accuracy and explainability. Black-box models achieve strong performance but lack interpretability needed for trust and adoption. Existing explainable AI approaches either treat explanations as post-hoc or at the cost of accuracy. We challenge this view, proposing that explanations, when designed as an integral component of a system and aligned with prediction outcomes, can improve both interpretability and performance. We introduce RecPIE (Recommendation with Prediction-Informed Explanations), a framework that jointly optimizes recommendation predictions and natural-language explanations generated by LLMs. RecPIE embeds explanation generation into the learning loop: predictions guide explanation generation (prediction-informed explanations), which are fed back to refine subsequent predictions (explanation-informed predictions) via alternating training. The LLM is fine-tuned using LoRA and reinforcement learning with a customized reward derived from recommendation accuracy. Drawing on multi-environment statistical learning theory, we formally ground why explanation generation and prediction can be mutually reinforcing. We evaluate RecPIE on large-scale point-of-interest recommendation data from Google Maps, where user preferences span diverse place categories. RecPIE improves predictive accuracy by 3-4% over state-of-the-art baselines and matches the best performing model using only 12% of the training data. In human evaluations with 566 participants, RecPIE explanations are preferred 61.5% of the time (versus 16.6% for the best baseline) and rated closer to human-generated explanations. These results reframe explainability not as a constraint on performance but as a design lever for improving AI systems, with implications for trust, data efficiency, and marketplace deployment.

Li Pan, Yupei Zhang, Qiushi Yang et al.

Recently computer-aided diagnosis has demonstrated promising performance, effectively alleviating the workload of clinicians. However, the inherent sample imbalance among different diseases leads algorithms biased to the majority categories, leading to poor performance for rare categories. Existing works formulated this challenge as a long-tailed problem and attempted to tackle it by decoupling the feature representation and classification. Yet, due to the imbalanced distribution and limited samples from tail classes, these works are prone to biased representation learning and insufficient classifier calibration. To tackle these problems, we propose a new Long-tailed Medical Diagnosis (LMD) framework for balanced medical image classification on long-tailed datasets. In the initial stage, we develop a Relation-aware Representation Learning (RRL) scheme to boost the representation ability by encouraging the encoder to capture intrinsic semantic features through different data augmentations. In the subsequent stage, we propose an Iterative Classifier Calibration (ICC) scheme to calibrate the classifier iteratively. This is achieved by generating a large number of balanced virtual features and fine-tuning the encoder using an Expectation-Maximization manner. The proposed ICC compensates for minority categories to facilitate unbiased classifier optimization while maintaining the diagnostic knowledge in majority classes. Comprehensive experiments on three public long-tailed medical datasets demonstrate that our LMD framework significantly surpasses state-of-the-art approaches. The source code can be accessed at https://github.com/peterlipan/LMD.