Kang Li

Xin Cao, Huan Xia, Xinxin Han et al.

Most deep learning-based point cloud processing methods are supervised and require large scale of labeled data. However, manual labeling of point cloud data is laborious and time-consuming. Self-supervised representation learning can address the aforementioned issue by learning robust and generalized representations from unlabeled datasets. Nevertheless, the embedded features obtained by representation learning usually contain redundant information, and most current methods reduce feature redundancy by linear correlation constraints. In this paper, we propose PointJEM, a self-supervised representation learning method applied to the point cloud field. PointJEM comprises an embedding scheme and a loss function based on joint entropy. The embedding scheme divides the embedding vector into different parts, each part can learn a distinctive feature. To reduce redundant information in the features, PointJEM maximizes the joint entropy between the different parts, thereby rendering the learned feature variables pairwise independent. To validate the effectiveness of our method, we conducted experiments on multiple datasets. The results demonstrate that our method can significantly reduce feature redundancy beyond linear correlation. Furthermore, PointJEM achieves competitive performance in downstream tasks such as classification and segmentation.

Huahui Yi, Xiaofei Wang, Kang Li et al.

Multimodal learning, integrating histology images and genomics, promises to enhance precision oncology with comprehensive views at microscopic and molecular levels. However, existing methods may not sufficiently model the shared or complementary information for more effective integration. In this study, we introduce a Unified Modeling Enhanced Multimodal Learning (UMEML) framework that employs a hierarchical attention structure to effectively leverage shared and complementary features of both modalities of histology and genomics. Specifically, to mitigate unimodal bias from modality imbalance, we utilize a query-based cross-attention mechanism for prototype clustering in the pathology encoder. Our prototype assignment and modularity strategy are designed to align shared features and minimizes modality gaps. An additional registration mechanism with learnable tokens is introduced to enhance cross-modal feature integration and robustness in multimodal unified modeling. Our experiments demonstrate that our method surpasses previous state-of-the-art approaches in glioma diagnosis and prognosis tasks, underscoring its superiority in precision neuro-Oncology.