Xiaoyan Li

Liyu Shi, Xiaoyan Li, Weiming Hu et al.

Background and Purpose: Colorectal cancer is a common fatal malignancy, the fourth most common cancer in men, and the third most common cancer in women worldwide. Timely detection of cancer in its early stages is essential for treating the disease. Currently, there is a lack of datasets for histopathological image segmentation of rectal cancer, which often hampers the assessment accuracy when computer technology is used to aid in diagnosis. Methods: This present study provided a new publicly available Enteroscope Biopsy Histopathological Hematoxylin and Eosin Image Dataset for Image Segmentation Tasks (EBHI-Seg). To demonstrate the validity and extensiveness of EBHI-Seg, the experimental results for EBHI-Seg are evaluated using classical machine learning methods and deep learning methods. Results: The experimental results showed that deep learning methods had a better image segmentation performance when utilizing EBHI-Seg. The maximum accuracy of the Dice evaluation metric for the classical machine learning method is 0.948, while the Dice evaluation metric for the deep learning method is 0.965. Conclusion: This publicly available dataset contained 5,170 images of six types of tumor differentiation stages and the corresponding ground truth images. The dataset can provide researchers with new segmentation algorithms for medical diagnosis of colorectal cancer, which can be used in the clinical setting to help doctors and patients.

Haoyuan Chen, Chen Li, Xiaoyan Li et al.

In recent years, colorectal cancer has become one of the most significant diseases that endanger human health. Deep learning methods are increasingly important for the classification of colorectal histopathology images. However, existing approaches focus more on end-to-end automatic classification using computers rather than human-computer interaction. In this paper, we propose an IL-MCAM framework. It is based on attention mechanisms and interactive learning. The proposed IL-MCAM framework includes two stages: automatic learning (AL) and interactivity learning (IL). In the AL stage, a multi-channel attention mechanism model containing three different attention mechanism channels and convolutional neural networks is used to extract multi-channel features for classification. In the IL stage, the proposed IL-MCAM framework continuously adds misclassified images to the training set in an interactive approach, which improves the classification ability of the MCAM model. We carried out a comparison experiment on our dataset and an extended experiment on the HE-NCT-CRC-100K dataset to verify the performance of the proposed IL-MCAM framework, achieving classification accuracies of 98.98% and 99.77%, respectively. In addition, we conducted an ablation experiment and an interchangeability experiment to verify the ability and interchangeability of the three channels. The experimental results show that the proposed IL-MCAM framework has excellent performance in the colorectal histopathological image classification tasks.

Yuchao Zheng, Chen Li, Xiaomin Zhou et al.

Background: Breast cancer has the highest prevalence in women globally. The classification and diagnosis of breast cancer and its histopathological images have always been a hot spot of clinical concern. In Computer-Aided Diagnosis (CAD), traditional classification models mostly use a single network to extract features, which has significant limitations. On the other hand, many networks are trained and optimized on patient-level datasets, ignoring the application of lower-level data labels. Method: This paper proposes a deep ensemble model based on image-level labels for the binary classification of benign and malignant lesions of breast histopathological images. First, the BreaKHis dataset is randomly divided into a training, validation and test set. Then, data augmentation techniques are used to balance the number of benign and malignant samples. Thirdly, considering the performance of transfer learning and the complementarity between each network, VGG16, Xception, ResNet50, DenseNet201 are selected as the base classifiers. Result: In the ensemble network model with accuracy as the weight, the image-level binary classification achieves an accuracy of $98.90\%$. In order to verify the capabilities of our method, the latest Transformer and Multilayer Perception (MLP) models have been experimentally compared on the same dataset. Our model wins with a $5\%-20\%$ advantage, emphasizing the ensemble model's far-reaching significance in classification tasks. Conclusion: This research focuses on improving the model's classification performance with an ensemble algorithm. Transfer learning plays an essential role in small datasets, improving training speed and accuracy. Our model has outperformed many existing approaches in accuracy, providing a method for the field of auxiliary medical diagnosis.

Weiming Hu, Haoyuan Chen, Wanli Liu et al.

Gastric cancer is the fifth most common cancer in the world. At the same time, it is also the fourth most deadly cancer. Early detection of cancer exists as a guide for the treatment of gastric cancer. Nowadays, computer technology has advanced rapidly to assist physicians in the diagnosis of pathological pictures of gastric cancer. Ensemble learning is a way to improve the accuracy of algorithms, and finding multiple learning models with complementarity types is the basis of ensemble learning. The complementarity of sub-size pathology image classifiers when machine performance is insufficient is explored in this experimental platform. We choose seven classical machine learning classifiers and four deep learning classifiers for classification experiments on the GasHisSDB database. Among them, classical machine learning algorithms extract five different image virtual features to match multiple classifier algorithms. For deep learning, we choose three convolutional neural network classifiers. In addition, we also choose a novel Transformer-based classifier. The experimental platform, in which a large number of classical machine learning and deep learning methods are performed, demonstrates that there are differences in the performance of different classifiers on GasHisSDB. Classical machine learning models exist for classifiers that classify Abnormal categories very well, while classifiers that excel in classifying Normal categories also exist. Deep learning models also exist with multiple models that can be complementarity. Suitable classifiers are selected for ensemble learning, when machine performance is insufficient. This experimental platform demonstrates that multiple classifiers are indeed complementarity and can improve the efficiency of ensemble learning. This can better assist doctors in diagnosis, improve the detection of gastric cancer, and increase the cure rate.

Xiaoyan Li, Gang Zhang, Hongyu Pan et al.

LiDAR semantic segmentation essential for advanced autonomous driving is required to be accurate, fast, and easy-deployed on mobile platforms. Previous point-based or sparse voxel-based methods are far away from real-time applications since time-consuming neighbor searching or sparse 3D convolution are employed. Recent 2D projection-based methods, including range view and multi-view fusion, can run in real time, but suffer from lower accuracy due to information loss during the 2D projection. Besides, to improve the performance, previous methods usually adopt test time augmentation (TTA), which further slows down the inference process. To achieve a better speed-accuracy trade-off, we propose Cascade Point-Grid Fusion Network (CPGNet), which ensures both effectiveness and efficiency mainly by the following two techniques: 1) the novel Point-Grid (PG) fusion block extracts semantic features mainly on the 2D projected grid for efficiency, while summarizes both 2D and 3D features on 3D point for minimal information loss; 2) the proposed transformation consistency loss narrows the gap between the single-time model inference and TTA. The experiments on the SemanticKITTI and nuScenes benchmarks demonstrate that the CPGNet without ensemble models or TTA is comparable with the state-of-the-art RPVNet, while it runs 4.7 times faster.

Jiawei Hou, Xiaoyan Li, Wenhao Guan et al.

In autonomous driving, 3D occupancy prediction outputs voxel-wise status and semantic labels for more comprehensive understandings of 3D scenes compared with traditional perception tasks, such as 3D object detection and bird's-eye view (BEV) semantic segmentation. Recent researchers have extensively explored various aspects of this task, including view transformation techniques, ground-truth label generation, and elaborate network design, aiming to achieve superior performance. However, the inference speed, crucial for running on an autonomous vehicle, is neglected. To this end, a new method, dubbed FastOcc, is proposed. By carefully analyzing the network effect and latency from four parts, including the input image resolution, image backbone, view transformation, and occupancy prediction head, it is found that the occupancy prediction head holds considerable potential for accelerating the model while keeping its accuracy. Targeted at improving this component, the time-consuming 3D convolution network is replaced with a novel residual-like architecture, where features are mainly digested by a lightweight 2D BEV convolution network and compensated by integrating the 3D voxel features interpolated from the original image features. Experiments on the Occ3D-nuScenes benchmark demonstrate that our FastOcc achieves state-of-the-art results with a fast inference speed.

Weiming Hu, Chen Li, Xiaoyan Li et al.

Background and purpose: Colorectal cancer has become the third most common cancer worldwide, accounting for approximately 10% of cancer patients. Early detection of the disease is important for the treatment of colorectal cancer patients. Histopathological examination is the gold standard for screening colorectal cancer. However, the current lack of histopathological image datasets of colorectal cancer, especially enteroscope biopsies, hinders the accurate evaluation of computer-aided diagnosis techniques. Methods: A new publicly available Enteroscope Biopsy Histopathological H&E Image Dataset (EBHI) is published in this paper. To demonstrate the effectiveness of the EBHI dataset, we have utilized several machine learning, convolutional neural networks and novel transformer-based classifiers for experimentation and evaluation, using an image with a magnification of 200x. Results: Experimental results show that the deep learning method performs well on the EBHI dataset. Traditional machine learning methods achieve maximum accuracy of 76.02% and deep learning method achieves a maximum accuracy of 95.37%. Conclusion: To the best of our knowledge, EBHI is the first publicly available colorectal histopathology enteroscope biopsy dataset with four magnifications and five types of images of tumor differentiation stages, totaling 5532 images. We believe that EBHI could attract researchers to explore new classification algorithms for the automated diagnosis of colorectal cancer, which could help physicians and patients in clinical settings.

Xiaoqi Li, Haoyuan Chen, Chen Li et al.

In the past ten years, the computing power of machine vision (MV) has been continuously improved, and image analysis algorithms have developed rapidly. At the same time, histopathological slices can be stored as digital images. Therefore, MV algorithms can provide doctors with diagnostic references. In particular, the continuous improvement of deep learning algorithms has further improved the accuracy of MV in disease detection and diagnosis. This paper reviews the applications of image processing technology based on MV in lymphoma histopathological images in recent years, including segmentation, classification and detection. Finally, the current methods are analyzed, some more potential methods are proposed, and further prospects are made.

Jiaxin Cao, Xiaoyan Li

In the proposed SEHybridSN model, a dense block was used to reuse shallow feature and aimed at better exploiting hierarchical spatial spectral feature. Subsequent depth separable convolutional layers were used to discriminate the spatial information. Further refinement of spatial spectral features was realized by the channel attention method, which were performed behind every 3D convolutional layer and every 2D convolutional layer. Experiment results indicate that our proposed model learn more discriminative spatial spectral features using very few training data. SEHybridSN using only 0.05 and 0.01 labeled data for training, a very satisfactory performance is obtained.

Haoyuan Chen, Chen Li, Ge Wang et al.

In this paper, a multi-scale visual transformer model, referred as GasHis-Transformer, is proposed for Gastric Histopathological Image Detection (GHID), which enables the automatic global detection of gastric cancer images. GasHis-Transformer model consists of two key modules designed to extract global and local information using a position-encoded transformer model and a convolutional neural network with local convolution, respectively. A publicly available hematoxylin and eosin (H&E) stained gastric histopathological image dataset is used in the experiment. Furthermore, a Dropconnect based lightweight network is proposed to reduce the model size and training time of GasHis-Transformer for clinical applications with improved confidence. Moreover, a series of contrast and extended experiments verify the robustness, extensibility and stability of GasHis-Transformer. In conclusion, GasHis-Transformer demonstrates high global detection performance and shows its significant potential in GHID task.

Chen Li, Xintong Li, Md Rahaman et al.

With the development of computer-aided diagnosis (CAD) and image scanning technology, Whole-slide Image (WSI) scanners are widely used in the field of pathological diagnosis. Therefore, WSI analysis has become the key to modern digital pathology. Since 2004, WSI has been used more and more in CAD. Since machine vision methods are usually based on semi-automatic or fully automatic computers, they are highly efficient and labor-saving. The combination of WSI and CAD technologies for segmentation, classification, and detection helps histopathologists obtain more stable and quantitative analysis results, save labor costs and improve diagnosis objectivity. This paper reviews the methods of WSI analysis based on machine learning. Firstly, the development status of WSI and CAD methods are introduced. Secondly, we discuss publicly available WSI datasets and evaluation metrics for segmentation, classification, and detection tasks. Then, the latest development of machine learning in WSI segmentation, classification, and detection are reviewed continuously. Finally, the existing methods are studied, the applicabilities of the analysis methods are analyzed, and the application prospects of the analysis methods in this field are forecasted.

Yixin Li, Xinran Wu, Chen Li et al.

In the Gastric Histopathology Image Classification (GHIC) tasks, which are usually weakly supervised learning missions, there is inevitably redundant information in the images. Therefore, designing networks that can focus on effective distinguishing features has become a popular research topic. In this paper, to accomplish the tasks of GHIC superiorly and to assist pathologists in clinical diagnosis, an intelligent Hierarchical Conditional Random Field based Attention Mechanism (HCRF-AM) model is proposed. The HCRF-AM model consists of an Attention Mechanism (AM) module and an Image Classification (IC) module. In the AM module, an HCRF model is built to extract attention regions. In the IC module, a Convolutional Neural Network (CNN) model is trained with the attention regions selected and then an algorithm called Classification Probability-based Ensemble Learning is applied to obtain the image-level results from patch-level output of the CNN. In the experiment, a classification specificity of 96.67% is achieved on a gastric histopathology dataset with 700 images. Our HCRF-AM model demonstrates high classification performance and shows its effectiveness and future potential in the GHIC field.

Changhao Sun, Chen Li, Jinghua Zhang et al.

For the Convolutional Neural Networks (CNNs) applied in the intelligent diagnosis of gastric cancer, existing methods mostly focus on individual characteristics or network frameworks without a policy to depict the integral information. Mainly, Conditional Random Field (CRF), an efficient and stable algorithm for analyzing images containing complicated contents, can characterize spatial relation in images. In this paper, a novel Hierarchical Conditional Random Field (HCRF) based Gastric Histopathology Image Segmentation (GHIS) method is proposed, which can automatically localize abnormal (cancer) regions in gastric histopathology images obtained by an optical microscope to assist histopathologists in medical work. This HCRF model is built up with higher order potentials, including pixel-level and patch-level potentials, and graph-based post-processing is applied to further improve its segmentation performance. Especially, a CNN is trained to build up the pixel-level potentials and another three CNNs are fine-tuned to build up the patch-level potentials for sufficient spatial segmentation information. In the experiment, a hematoxylin and eosin (H&E) stained gastric histopathological dataset with 560 abnormal images are divided into training, validation and test sets with a ratio of 1 : 1 : 2. Finally, segmentation accuracy, recall and specificity of 78.91%, 65.59%, and 81.33% are achieved on the test set. Our HCRF model demonstrates high segmentation performance and shows its effectiveness and future potential in the GHIS field.

Xiaoyan Li, Meina Kan, Shiguang Shan et al.

Weakly supervised object detection aims at learning precise object detectors, given image category labels. In recent prevailing works, this problem is generally formulated as a multiple instance learning module guided by an image classification loss. The object bounding box is assumed to be the one contributing most to the classification among all proposals. However, the region contributing most is also likely to be a crucial part or the supporting context of an object. To obtain a more accurate detector, in this work we propose a novel end-to-end weakly supervised detection approach, where a newly introduced generative adversarial segmentation module interacts with the conventional detection module in a collaborative loop. The collaboration mechanism takes full advantages of the complementary interpretations of the weakly supervised localization task, namely detection and segmentation tasks, forming a more comprehensive solution. Consequently, our method obtains more precise object bounding boxes, rather than parts or irrelevant surroundings. Expectedly, the proposed method achieves an accuracy of 51.0% on the PASCAL VOC 2007 dataset, outperforming the state-of-the-arts and demonstrating its superiority for weakly supervised object detection.