9.4LGOct 13, 2025
Variational Mixture of Graph Neural Experts for Alzheimer's Disease Biomarker Recognition in EEG Brain NetworksJun-En Ding, Anna Zilverstand, Shihao Yang et al.
Dementia disorders such as Alzheimer's disease (AD) and frontotemporal dementia (FTD) exhibit overlapping electrophysiological signatures in EEG that challenge accurate diagnosis. Existing EEG-based methods are limited by full-band frequency analysis that hinders precise differentiation of dementia subtypes and severity stages. We propose a variational mixture of graph neural experts (VMoGE) that integrates frequency-specific biomarker identification with structured variational inference for enhanced dementia diagnosis and staging. VMoGE employs a multi-granularity transformer to extract multi-scale temporal patterns across four frequency bands, followed by a variational graph convolutional encoder using Gaussian Markov Random Field priors. Through structured variational inference and adaptive gating, VMoGE links neural specialization to physiologically meaningful EEG frequency bands. Evaluated on two diverse datasets for both subtype classification and severity staging, VMoGE achieves superior performance with AUC improvements of +4% to +10% over state-of-the-art methods. Moreover, VMoGE provides interpretable insights through expert weights that correlate with clinical indicators and spatial patterns aligned with neuropathological signatures, facilitating EEG biomarker discovery for comprehensive dementia diagnosis and monitoring.
From Goals, Waypoints & Paths To Long Term Human Trajectory ForecastingKarttikeya Mangalam, Yang An, Harshayu Girase et al.
Human trajectory forecasting is an inherently multi-modal problem. Uncertainty in future trajectories stems from two sources: (a) sources that are known to the agent but unknown to the model, such as long term goals and (b)sources that are unknown to both the agent & the model, such as intent of other agents & irreducible randomness indecisions. We propose to factorize this uncertainty into its epistemic & aleatoric sources. We model the epistemic un-certainty through multimodality in long term goals and the aleatoric uncertainty through multimodality in waypoints& paths. To exemplify this dichotomy, we also propose a novel long term trajectory forecasting setting, with prediction horizons upto a minute, an order of magnitude longer than prior works. Finally, we presentY-net, a scene com-pliant trajectory forecasting network that exploits the pro-posed epistemic & aleatoric structure for diverse trajectory predictions across long prediction horizons.Y-net significantly improves previous state-of-the-art performance on both (a) The well studied short prediction horizon settings on the Stanford Drone & ETH/UCY datasets and (b) The proposed long prediction horizon setting on the re-purposed Stanford Drone & Intersection Drone datasets.