Yixin Li

Haoyuan Chen, Chen Li, Xiaoyan Li et al.

In recent years, colorectal cancer has become one of the most significant diseases that endanger human health. Deep learning methods are increasingly important for the classification of colorectal histopathology images. However, existing approaches focus more on end-to-end automatic classification using computers rather than human-computer interaction. In this paper, we propose an IL-MCAM framework. It is based on attention mechanisms and interactive learning. The proposed IL-MCAM framework includes two stages: automatic learning (AL) and interactivity learning (IL). In the AL stage, a multi-channel attention mechanism model containing three different attention mechanism channels and convolutional neural networks is used to extract multi-channel features for classification. In the IL stage, the proposed IL-MCAM framework continuously adds misclassified images to the training set in an interactive approach, which improves the classification ability of the MCAM model. We carried out a comparison experiment on our dataset and an extended experiment on the HE-NCT-CRC-100K dataset to verify the performance of the proposed IL-MCAM framework, achieving classification accuracies of 98.98% and 99.77%, respectively. In addition, we conducted an ablation experiment and an interchangeability experiment to verify the ability and interchangeability of the three channels. The experimental results show that the proposed IL-MCAM framework has excellent performance in the colorectal histopathological image classification tasks.

Yuchao Zheng, Chen Li, Xiaomin Zhou et al.

Background: Breast cancer has the highest prevalence in women globally. The classification and diagnosis of breast cancer and its histopathological images have always been a hot spot of clinical concern. In Computer-Aided Diagnosis (CAD), traditional classification models mostly use a single network to extract features, which has significant limitations. On the other hand, many networks are trained and optimized on patient-level datasets, ignoring the application of lower-level data labels. Method: This paper proposes a deep ensemble model based on image-level labels for the binary classification of benign and malignant lesions of breast histopathological images. First, the BreaKHis dataset is randomly divided into a training, validation and test set. Then, data augmentation techniques are used to balance the number of benign and malignant samples. Thirdly, considering the performance of transfer learning and the complementarity between each network, VGG16, Xception, ResNet50, DenseNet201 are selected as the base classifiers. Result: In the ensemble network model with accuracy as the weight, the image-level binary classification achieves an accuracy of $98.90\%$. In order to verify the capabilities of our method, the latest Transformer and Multilayer Perception (MLP) models have been experimentally compared on the same dataset. Our model wins with a $5\%-20\%$ advantage, emphasizing the ensemble model's far-reaching significance in classification tasks. Conclusion: This research focuses on improving the model's classification performance with an ensemble algorithm. Transfer learning plays an essential role in small datasets, improving training speed and accuracy. Our model has outperformed many existing approaches in accuracy, providing a method for the field of auxiliary medical diagnosis.

Irene Li, Jessica Pan, Jeremy Goldwasser et al.

Electronic health records (EHRs), digital collections of patient healthcare events and observations, are ubiquitous in medicine and critical to healthcare delivery, operations, and research. Despite this central role, EHRs are notoriously difficult to process automatically. Well over half of the information stored within EHRs is in the form of unstructured text (e.g. provider notes, operation reports) and remains largely untapped for secondary use. Recently, however, newer neural network and deep learning approaches to Natural Language Processing (NLP) have made considerable advances, outperforming traditional statistical and rule-based systems on a variety of tasks. In this survey paper, we summarize current neural NLP methods for EHR applications. We focus on a broad scope of tasks, namely, classification and prediction, word embeddings, extraction, generation, and other topics such as question answering, phenotyping, knowledge graphs, medical dialogue, multilinguality, interpretability, etc.

Haoyuan Chen, Chen Li, Ge Wang et al.

In this paper, a multi-scale visual transformer model, referred as GasHis-Transformer, is proposed for Gastric Histopathological Image Detection (GHID), which enables the automatic global detection of gastric cancer images. GasHis-Transformer model consists of two key modules designed to extract global and local information using a position-encoded transformer model and a convolutional neural network with local convolution, respectively. A publicly available hematoxylin and eosin (H&E) stained gastric histopathological image dataset is used in the experiment. Furthermore, a Dropconnect based lightweight network is proposed to reduce the model size and training time of GasHis-Transformer for clinical applications with improved confidence. Moreover, a series of contrast and extended experiments verify the robustness, extensibility and stability of GasHis-Transformer. In conclusion, GasHis-Transformer demonstrates high global detection performance and shows its significant potential in GHID task.

Yixin Li, Xinran Wu, Chen Li et al.

In the Gastric Histopathology Image Classification (GHIC) tasks, which are usually weakly supervised learning missions, there is inevitably redundant information in the images. Therefore, designing networks that can focus on effective distinguishing features has become a popular research topic. In this paper, to accomplish the tasks of GHIC superiorly and to assist pathologists in clinical diagnosis, an intelligent Hierarchical Conditional Random Field based Attention Mechanism (HCRF-AM) model is proposed. The HCRF-AM model consists of an Attention Mechanism (AM) module and an Image Classification (IC) module. In the AM module, an HCRF model is built to extract attention regions. In the IC module, a Convolutional Neural Network (CNN) model is trained with the attention regions selected and then an algorithm called Classification Probability-based Ensemble Learning is applied to obtain the image-level results from patch-level output of the CNN. In the experiment, a classification specificity of 96.67% is achieved on a gastric histopathology dataset with 700 images. Our HCRF-AM model demonstrates high classification performance and shows its effectiveness and future potential in the GHIC field.

Irene Li, Yixin Li, Tianxiao Li et al.

The outbreak of coronavirus disease 2019 (COVID-19) recently has affected human life to a great extent. Besides direct physical and economic threats, the pandemic also indirectly impact people's mental health conditions, which can be overwhelming but difficult to measure. The problem may come from various reasons such as unemployment status, stay-at-home policy, fear for the virus, and so forth. In this work, we focus on applying natural language processing (NLP) techniques to analyze tweets in terms of mental health. We trained deep models that classify each tweet into the following emotions: anger, anticipation, disgust, fear, joy, sadness, surprise and trust. We build the EmoCT (Emotion-Covid19-Tweet) dataset for the training purpose by manually labeling 1,000 English tweets. Furthermore, we propose and compare two methods to find out the reasons that are causing sadness and fear.

Changhao Sun, Chen Li, Jinghua Zhang et al.

For the Convolutional Neural Networks (CNNs) applied in the intelligent diagnosis of gastric cancer, existing methods mostly focus on individual characteristics or network frameworks without a policy to depict the integral information. Mainly, Conditional Random Field (CRF), an efficient and stable algorithm for analyzing images containing complicated contents, can characterize spatial relation in images. In this paper, a novel Hierarchical Conditional Random Field (HCRF) based Gastric Histopathology Image Segmentation (GHIS) method is proposed, which can automatically localize abnormal (cancer) regions in gastric histopathology images obtained by an optical microscope to assist histopathologists in medical work. This HCRF model is built up with higher order potentials, including pixel-level and patch-level potentials, and graph-based post-processing is applied to further improve its segmentation performance. Especially, a CNN is trained to build up the pixel-level potentials and another three CNNs are fine-tuned to build up the patch-level potentials for sufficient spatial segmentation information. In the experiment, a hematoxylin and eosin (H&E) stained gastric histopathological dataset with 560 abnormal images are divided into training, validation and test sets with a ratio of 1 : 1 : 2. Finally, segmentation accuracy, recall and specificity of 78.91%, 65.59%, and 81.33% are achieved on the test set. Our HCRF model demonstrates high segmentation performance and shows its effectiveness and future potential in the GHIS field.