Jianfeng Li

Zhigen Li, Yanmeng Wang, Rizhao Fan et al.

Paraphrase generation is a longstanding NLP task and achieves great success with the aid of large corpora. However, transferring a paraphrasing model to another domain encounters the problem of domain shifting especially when the data is sparse. At the same time, widely using large pre-trained language models (PLMs) faces the overfitting problem when training on scarce labeled data. To mitigate these two issues, we propose, LAPA, an effective adapter for PLMs optimized by meta-learning. LAPA has three-stage training on three types of related resources to solve this problem: 1. pre-training PLMs on unsupervised corpora, 2. inserting an adapter layer and meta-training on source domain labeled data, and 3. fine-tuning adapters on a small amount of target domain labeled data. This method enables paraphrase generation models to learn basic language knowledge first, then learn the paraphrasing task itself later, and finally adapt to the target task. Our experimental results demonstrate that LAPA achieves state-of-the-art in supervised, unsupervised, and low-resource settings on three benchmark datasets. With only 2\% of trainable parameters and 1\% labeled data of the target task, our approach can achieve a competitive performance with previous work.

Qinyu Ma, Yuhao Zhou, Jianfeng Li

Identifying reliable synthesis pathways in materials chemistry is a complex task, particularly in polymer science, due to the intricate and often non-unique nomenclature of macromolecules. To address this challenge, we propose an agent system that integrates large language models (LLMs) and knowledge graphs. By leveraging LLMs' powerful capabilities for extracting and recognizing chemical substance names, and storing the extracted data in a structured knowledge graph, our system fully automates the retrieval of relevant literatures, extraction of reaction data, database querying, construction of retrosynthetic pathway trees, further expansion through the retrieval of additional literature and recommendation of optimal reaction pathways. By considering the complex interdependencies among chemical reactants, a novel Multi-branched Reaction Pathway Search Algorithm (MBRPS) is proposed to help identify all valid multi-branched reaction pathways, which arise when a single product decomposes into multiple reaction intermediates. In contrast, previous studies were limited to cases where a product decomposes into at most one reaction intermediate. This work represents the first attempt to develop a fully automated retrosynthesis planning agent tailored specially for macromolecules powered by LLMs. Applied to polyimide synthesis, our new approach constructs a retrosynthetic pathway tree with hundreds of pathways and recommends optimized routes, including both known and novel pathways. This demonstrates utilizing LLMs for literature consultation to accomplish specific tasks is possible and crucial for future materials research, given the vast amount of materials-related literature.

Fujiao Ju, Yuxuan Wang, Shuo Wang et al.

Adolescent idiopathic scoliosis (AIS), a prevalent spinal deformity, significantly affects individuals' health and quality of life. Conventional imaging techniques, such as X - rays, computed tomography (CT), and magnetic resonance imaging (MRI), offer static views of the spine. However, they are restricted in capturing the dynamic changes of the spine and its interactions with overall body motion. Therefore, developing new techniques to address these limitations has become extremely important. Dynamic digital human modeling represents a major breakthrough in digital medicine. It enables a three - dimensional (3D) view of the spine as it changes during daily activities, assisting clinicians in detecting deformities that might be missed in static imaging. Although dynamic modeling holds great potential, constructing an accurate static digital human model is a crucial initial step for high - precision simulations. In this study, our focus is on constructing an accurate static digital human model integrating the spine, which is vital for subsequent dynamic digital human research on AIS. First, we generate human point - cloud data by combining the 3D Gaussian method with the Skinned Multi - Person Linear (SMPL) model from the patient's multi - view images. Then, we fit a standard skeletal model to the generated human model. Next, we align the real spine model reconstructed from CT images with the standard skeletal model. We validated the resulting personalized spine model using X - ray data from six AIS patients, with Cobb angles (used to measure the severity of scoliosis) as evaluation metrics. The results indicate that the model's error was within 1 degree of the actual measurements. This study presents an important method for constructing digital humans.