Shirui Qin

Zilin Wang, Shengqi Chen, Jianrong Dai et al.

Objective:To develop a no-reference image quality assessment method using automated distortion recognition to boost MRI-guided radiotherapy precision.Methods:We analyzed 106,000 MR images from 10 patients with liver metastasis,captured with the Elekta Unity MR-LINAC.Our No-Reference Quality Assessment Model includes:1)image preprocessing to enhance visibility of key diagnostic features;2)feature extraction and directional analysis using MSCN coefficients across four directions to capture textural attributes and gradients,vital for identifying image features and potential distortions;3)integrative Quality Index(QI)calculation,which integrates features via AGGD parameter estimation and K-means clustering.The QI,based on a weighted MAD computation of directional scores,provides a comprehensive image quality measure,robust against outliers.LOO-CV assessed model generalizability and performance.Tumor tracking algorithm performance was compared with and without preprocessing to verify tracking accuracy enhancements.Results:Preprocessing significantly improved image quality,with the QI showing substantial positive changes and surpassing other metrics.After normalization,the QI's average value was 79.6 times higher than CNR,indicating improved image definition and contrast.It also showed higher sensitivity in detail recognition with average values 6.5 times and 1.7 times higher than Tenengrad gradient and entropy.The tumor tracking algorithm confirmed significant tracking accuracy improvements with preprocessed images,validating preprocessing effectiveness.Conclusions:This study introduces a novel no-reference image quality evaluation method based on automated distortion recognition,offering a new quality control tool for MRIgRT tumor tracking.It enhances clinical application accuracy and facilitates medical image quality assessment standardization, with significant clinical and research value.

Shengqi Chen, Zilin Wang, Jianrong Dai et al.

Background and Purpose: Accurate motion tracking in MRI-guided Radiotherapy (MRIgRT) is essential for effective treatment delivery. This study aimed to enhance motion tracking precision in MRIgRT through an automatic real-time markerless tracking method using an enhanced Tracking-Learning-Detection (ETLD) framework with automatic segmentation. Materials and Methods: We developed a novel MRIgRT motion tracking and segmentation method by integrating the ETLD framework with an improved Chan-Vese model (ICV), named ETLD+ICV. The ETLD framework was upgraded for real-time cine MRI, including advanced image preprocessing, no-reference image quality assessment, an enhanced median-flow tracker, and a refined detector with dynamic search region adjustments. ICV was used for precise target volume coverage, refining the segmented region frame by frame using tracking results, with key parameters optimized. The method was tested on 3.5D MRI scans from 10 patients with liver metastases. Results: Evaluation of 106,000 frames across 77 treatment fractions showed sub-millimeter tracking errors of less than 0.8mm, with over 99% precision and 98% recall for all subjects in the Beam Eye View(BEV)/Beam Path View(BPV) orientation. The ETLD+ICV method achieved a dice global score of more than 82% for all subjects, demonstrating the method's extensibility and precise target volume coverage. Conclusion: This study successfully developed an automatic real-time markerless motion tracking method for MRIgRT that significantly outperforms current methods. The novel method not only delivers exceptional precision in tracking and segmentation but also shows enhanced adaptability to clinical demands, making it an indispensable asset in improving the efficacy of radiotherapy treatments.