Liang Zhao

Yiwen Shi, Ping Ren, Jing Wang et al.

Food effect summarization from New Drug Application (NDA) is an essential component of product-specific guidance (PSG) development and assessment. However, manual summarization of food effect from extensive drug application review documents is time-consuming, which arouses a need to develop automated methods. Recent advances in large language models (LLMs) such as ChatGPT and GPT-4, have demonstrated great potential in improving the effectiveness of automated text summarization, but its ability regarding the accuracy in summarizing food effect for PSG assessment remains unclear. In this study, we introduce a simple yet effective approach, iterative prompting, which allows one to interact with ChatGPT or GPT-4 more effectively and efficiently through multi-turn interaction. Specifically, we propose a three-turn iterative prompting approach to food effect summarization in which the keyword-focused and length-controlled prompts are respectively provided in consecutive turns to refine the quality of the generated summary. We conduct a series of extensive evaluations, ranging from automated metrics to FDA professionals and even evaluation by GPT-4, on 100 NDA review documents selected over the past five years. We observe that the summary quality is progressively improved throughout the process. Moreover, we find that GPT-4 performs better than ChatGPT, as evaluated by FDA professionals (43% vs. 12%) and GPT-4 (64% vs. 35%). Importantly, all the FDA professionals unanimously rated that 85% of the summaries generated by GPT-4 are factually consistent with the golden reference summary, a finding further supported by GPT-4 rating of 72% consistency. These results strongly suggest a great potential for GPT-4 to draft food effect summaries that could be reviewed by FDA professionals, thereby improving the efficiency of PSG assessment cycle and promoting the generic drug product development.

Zheng Zhang, Hossein Amiri, Zhenke Liu et al.

Identifying anomalous human spatial trajectory patterns can indicate dynamic changes in mobility behavior with applications in domains like infectious disease monitoring and elderly care. Recent advancements in large language models (LLMs) have demonstrated their ability to reason in a manner akin to humans. This presents significant potential for analyzing temporal patterns in human mobility. In this paper, we conduct empirical studies to assess the capabilities of leading LLMs like GPT-4 and Claude-2 in detecting anomalous behaviors from mobility data, by comparing to specialized methods. Our key findings demonstrate that LLMs can attain reasonable anomaly detection performance even without any specific cues. In addition, providing contextual clues about potential irregularities could further enhances their prediction efficacy. Moreover, LLMs can provide reasonable explanations for their judgments, thereby improving transparency. Our work provides insights on the strengths and limitations of LLMs for human spatial trajectory analysis.

Bo Pan, Muran Qin, Shiyu Wang et al.

Deep generative models have been widely used for their ability to generate realistic data samples in various areas, such as images, molecules, text, and speech. One major goal of data generation is controllability, namely to generate new data with desired properties. Despite growing interest in the area of controllable generation, significant challenges still remain, including 1) disentangling desired properties with unrelated latent variables, 2) out-of-distribution property control, and 3) objective optimization for out-of-distribution property control. To address these challenges, in this paper, we propose a general framework to enhance VAE-based data generators with property controllability and ensure disentanglement. Our proposed objective can be optimized on both data seen and unseen in the training set. We propose a training procedure to train the objective in a semi-supervised manner by iteratively conducting mutual mappings between the data and properties. The proposed framework is implemented on four VAE-based controllable generators to evaluate its performance on property error, disentanglement, generation quality, and training time. The results indicate that our proposed framework enables more precise control over the properties of generated samples in a short training time, ensuring the disentanglement and keeping the validity of the generated samples.

Jingyang Yuan, Huazuo Gao, Damai Dai et al. · pku

Long-context modeling is crucial for next-generation language models, yet the high computational cost of standard attention mechanisms poses significant computational challenges. Sparse attention offers a promising direction for improving efficiency while maintaining model capabilities. We present NSA, a Natively trainable Sparse Attention mechanism that integrates algorithmic innovations with hardware-aligned optimizations to achieve efficient long-context modeling. NSA employs a dynamic hierarchical sparse strategy, combining coarse-grained token compression with fine-grained token selection to preserve both global context awareness and local precision. Our approach advances sparse attention design with two key innovations: (1) We achieve substantial speedups through arithmetic intensity-balanced algorithm design, with implementation optimizations for modern hardware. (2) We enable end-to-end training, reducing pretraining computation without sacrificing model performance. As shown in Figure 1, experiments show the model pretrained with NSA maintains or exceeds Full Attention models across general benchmarks, long-context tasks, and instruction-based reasoning. Meanwhile, NSA achieves substantial speedups over Full Attention on 64k-length sequences across decoding, forward propagation, and backward propagation, validating its efficiency throughout the model lifecycle.

Weihong Zhong, Xiaocheng Feng, Liang Zhao et al.

Though advanced in understanding visual information with human languages, Large Vision-Language Models (LVLMs) still suffer from multimodal hallucinations. A natural concern is that during multimodal interaction, the generated hallucinations could influence the LVLMs' subsequent generation. Thus, we raise a question: When presented with a query relevant to the previously generated hallucination, will LVLMs be misled and respond incorrectly, even though the ground visual information exists? To answer this, we propose a framework called MMHalSnowball to evaluate LVLMs' behaviors when encountering generated hallucinations, where LVLMs are required to answer specific visual questions within a curated hallucinatory conversation. Crucially, our experiment shows that the performance of open-source LVLMs drops by at least $31\%$, indicating that LVLMs are prone to accept the generated hallucinations and make false claims that they would not have supported without distractions. We term this phenomenon Multimodal Hallucination Snowballing. To mitigate this, we further propose a training-free method called Residual Visual Decoding, where we revise the output distribution of LVLMs with the one derived from the residual visual input, providing models with direct access to the visual information. Experiments show that our method can mitigate more than $24\%$ of the snowballed multimodal hallucination while maintaining capabilities.

Bo Pan, Zheng Zhang, Yifei Zhang et al.

Text-Attributed Graphs (TAGs) are graphs of connected textual documents. Graph models can efficiently learn TAGs, but their training heavily relies on human-annotated labels, which are scarce or even unavailable in many applications. Large language models (LLMs) have recently demonstrated remarkable capabilities in few-shot and zero-shot TAG learning, but they suffer from scalability, cost, and privacy issues. Therefore, in this work, we focus on synergizing LLMs and graph models with their complementary strengths by distilling the power of LLMs to a local graph model on TAG learning. To address the inherent gaps between LLMs (generative models for texts) and graph models (discriminative models for graphs), we propose first to let LLMs teach an interpreter with rich textual rationale and then let a student model mimic the interpreter's reasoning without LLMs' textual rationale. Extensive experiments validate the efficacy of our proposed framework.

Lei Huang, Xiaocheng Feng, Weitao Ma et al.

Teaching large language models (LLMs) to generate text with citations to evidence sources can mitigate hallucinations and enhance verifiability in information-seeking systems. However, improving this capability requires high-quality attribution data, which is costly and labor-intensive. Inspired by recent advances in self-improvement that enhance LLMs without manual annotation, we present START, a Self-Taught AttRibuTion framework for iteratively improving the attribution capability of LLMs. First, to prevent models from stagnating due to initially insufficient supervision signals, START leverages the model to self-construct synthetic training data for warming up. To further self-improve the model's attribution ability, START iteratively utilizes fine-grained preference supervision signals constructed from its sampled responses to encourage robust, comprehensive, and attributable generation. Experiments on three open-domain question-answering datasets, covering long-form QA and multi-step reasoning, demonstrate significant performance gains of 25.13% on average without relying on human annotations and more advanced models. Further analysis reveals that START excels in aggregating information across multiple sources.

Guangji Bai, Yijiang Li, Zilinghan Li et al.

Large Language Models (LLMs) achieve state-of-the-art performance but are challenging to deploy due to their high computational and storage demands. Pruning can reduce model size, yet existing methods assume public access to calibration data, which is impractical for privacy-sensitive applications. To address the challenge of pruning LLMs in privacy-preserving settings, we propose FedSpaLLM, the first federated learning framework designed specifically for pruning LLMs. FedSpaLLM enables clients to prune their models locally based on private data while accounting for system heterogeneity and maintaining communication efficiency. Our framework introduces several key innovations: (1) a novel $\ell_0$-norm aggregation function that ensures only non-zero weights are averaged across clients, preserving important model parameters; (2) an adaptive mask expansion technique that meets global sparsity targets while accommodating client-specific pruning decisions; and (3) a layer sampling strategy that reduces communication overhead and personalizes the pruning process based on client resources. Extensive experiments show that FedSpaLLM improves pruning performance in diverse federated settings.