Yan Zhu

Shuo Wang, Yan Zhu, Xiaoyuan Luo et al.

The development of artificial intelligence systems for colonoscopy analysis often necessitates expert-annotated image datasets. However, limitations in dataset size and diversity impede model performance and generalisation. Image-text colonoscopy records from routine clinical practice, comprising millions of images and text reports, serve as a valuable data source, though annotating them is labour-intensive. Here we leverage recent advancements in large language and vision models and propose EndoKED, a data mining paradigm for deep knowledge extraction and distillation. EndoKED automates the transformation of raw colonoscopy records into image datasets with pixel-level annotation. We validate EndoKED using multi-centre datasets of raw colonoscopy records (~1 million images), demonstrating its superior performance in training polyp detection and segmentation models. Furthermore, the EndoKED pre-trained vision backbone enables data-efficient and generalisable learning for optical biopsy, achieving expert-level performance in both retrospective and prospective validation.

Hao Zhu, Yan Zhu, Jiayu Xiao et al.

Automated crop mapping through Satellite Image Time Series (SITS) has emerged as a crucial avenue for agricultural monitoring and management. However, due to the low resolution and unclear parcel boundaries, annotating pixel-level masks is exceptionally complex and time-consuming in SITS. This paper embraces the weakly supervised paradigm (i.e., only image-level categories available) to liberate the crop mapping task from the exhaustive annotation burden. The unique characteristics of SITS give rise to several challenges in weakly supervised learning: (1) noise perturbation from spatially neighboring regions, and (2) erroneous semantic bias from anomalous temporal periods. To address the above difficulties, we propose a novel method, termed exploring space-time perceptive clues (Exact). First, we introduce a set of spatial clues to explicitly capture the representative patterns of different crops from the most class-relative regions. Besides, we leverage the temporal-to-class interaction of the model to emphasize the contributions of pivotal clips, thereby enhancing the model perception for crop regions. Build upon the space-time perceptive clues, we derive the clue-based CAMs to effectively supervise the SITS segmentation network. Our method demonstrates impressive performance on various SITS benchmarks. Remarkably, the segmentation network trained on Exact-generated masks achieves 95% of its fully supervised performance, showing the bright promise of weakly supervised paradigm in crop mapping scenario. Our code will be publicly available.

Ruijie Yang, Yan Zhu, Peiyao Fu et al.

Determining the necessity of resecting malignant polyps during colonoscopy screen is crucial for patient outcomes, yet challenging due to the time-consuming and costly nature of histopathology examination. While deep learning-based classification models have shown promise in achieving optical biopsy with endoscopic images, they often suffer from a lack of explainability. To overcome this limitation, we introduce EndoFinder, a content-based image retrieval framework to find the 'digital twin' polyp in the reference database given a newly detected polyp. The clinical semantics of the new polyp can be inferred referring to the matched ones. EndoFinder pioneers a polyp-aware image encoder that is pre-trained on a large polyp dataset in a self-supervised way, merging masked image modeling with contrastive learning. This results in a generic embedding space ready for different downstream clinical tasks based on image retrieval. We validate the framework on polyp re-identification and optical biopsy tasks, with extensive experiments demonstrating that EndoFinder not only achieves explainable diagnostics but also matches the performance of supervised classification models. EndoFinder's reliance on image retrieval has the potential to support diverse downstream decision-making tasks during real-time colonoscopy procedures.

Yili He, Yan Zhu, Peiyao Fu et al.

Pre-training on image-text colonoscopy records offers substantial potential for improving endoscopic image analysis, but faces challenges including non-informative background images, complex medical terminology, and ambiguous multi-lesion descriptions. We introduce Endo-CLIP, a novel self-supervised framework that enhances Contrastive Language-Image Pre-training (CLIP) for this domain. Endo-CLIP's three-stage framework--cleansing, attunement, and unification--addresses these challenges by (1) removing background frames, (2) leveraging large language models to extract clinical attributes for fine-grained contrastive learning, and (3) employing patient-level cross-attention to resolve multi-polyp ambiguities. Extensive experiments demonstrate that Endo-CLIP significantly outperforms state-of-the-art pre-training methods in zero-shot and few-shot polyp detection and classification, paving the way for more accurate and clinically relevant endoscopic analysis.