Weixiong Lin

Chaoyi Wu, Jiayu Lei, Qiaoyu Zheng et al. · harvard

Driven by the large foundation models, the development of artificial intelligence has witnessed tremendous progress lately, leading to a surge of general interest from the public. In this study, we aim to assess the performance of OpenAI's newest model, GPT-4V(ision), specifically in the realm of multimodal medical diagnosis. Our evaluation encompasses 17 human body systems, including Central Nervous System, Head and Neck, Cardiac, Chest, Hematology, Hepatobiliary, Gastrointestinal, Urogenital, Gynecology, Obstetrics, Breast, Musculoskeletal, Spine, Vascular, Oncology, Trauma, Pediatrics, with images taken from 8 modalities used in daily clinic routine, e.g., X-ray, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Digital Subtraction Angiography (DSA), Mammography, Ultrasound, and Pathology. We probe the GPT-4V's ability on multiple clinical tasks with or without patent history provided, including imaging modality and anatomy recognition, disease diagnosis, report generation, disease localisation. Our observation shows that, while GPT-4V demonstrates proficiency in distinguishing between medical image modalities and anatomy, it faces significant challenges in disease diagnosis and generating comprehensive reports. These findings underscore that while large multimodal models have made significant advancements in computer vision and natural language processing, it remains far from being used to effectively support real-world medical applications and clinical decision-making. All images used in this report can be found in https://github.com/chaoyi-wu/GPT-4V_Medical_Evaluation.

Weixiong Lin, Ziheng Zhao, Xiaoman Zhang et al. · harvard

Foundation models trained on large-scale dataset gain a recent surge in CV and NLP. In contrast, development in biomedical domain lags far behind due to data scarcity. To address this issue, we build and release PMC-OA, a biomedical dataset with 1.6M image-caption pairs collected from PubMedCentral's OpenAccess subset, which is 8 times larger than before. PMC-OA covers diverse modalities or diseases, with majority of the image-caption samples aligned at finer-grained level, i.e., subfigure and subcaption. While pretraining a CLIP-style model on PMC-OA, our model named PMC-CLIP achieves state-of-the-art results on various downstream tasks, including image-text retrieval on ROCO, MedMNIST image classification, Medical VQA, i.e. +8.1% R@10 on image-text retrieval, +3.9% accuracy on image classification.

Pengcheng Qiu, Chaoyi Wu, Xiaoman Zhang et al. · harvard

The development of open-source, multilingual medical language models can benefit a wide, linguistically diverse audience from different regions. To promote this domain, we present contributions from the following: First, we construct a multilingual medical corpus, containing approximately 25.5B tokens encompassing 6 main languages, termed as MMedC, enabling auto-regressive domain adaptation for general LLMs; Second, to monitor the development of multilingual medical LLMs, we propose a multilingual medical multi-choice question-answering benchmark with rationale, termed as MMedBench; Third, we have assessed a number of open-source large language models (LLMs) on our benchmark, along with those further auto-regressive trained on MMedC. Our final model, MMed-Llama 3, with only 8B parameters, achieves superior performance compared to all other open-source models on both MMedBench and English benchmarks, even rivaling GPT-4. In conclusion, in this work, we present a large-scale corpus, a benchmark and a series of models to support the development of multilingual medical LLMs.

Haicheng Wang, Chen Ju, Weixiong Lin et al.

Temporal sentence grounding aims to detect event timestamps described by the natural language query from given untrimmed videos. The existing fully-supervised setting achieves great results but requires expensive annotation costs; while the weakly-supervised setting adopts cheap labels but performs poorly. To pursue high performance with less annotation costs, this paper introduces an intermediate partially-supervised setting, i.e., only short-clip is available during training. To make full use of partial labels, we specially design one contrast-unity framework, with the two-stage goal of implicit-explicit progressive grounding. In the implicit stage, we align event-query representations at fine granularity using comprehensive quadruple contrastive learning: event-query gather, event-background separation, intra-cluster compactness and inter-cluster separability. Then, high-quality representations bring acceptable grounding pseudo-labels. In the explicit stage, to explicitly optimize grounding objectives, we train one fully-supervised model using obtained pseudo-labels for grounding refinement and denoising. Extensive experiments and thoroughly ablations on Charades-STA and ActivityNet Captions demonstrate the significance of partial supervision, as well as our superior performance.

Shengchao Hu, Wanru Zhao, Weixiong Lin et al.

Offline reinforcement learning (RL) methods harness previous experiences to derive an optimal policy, forming the foundation for pre-trained large-scale models (PLMs). When encountering tasks not seen before, PLMs often utilize several expert trajectories as prompts to expedite their adaptation to new requirements. Though a range of prompt-tuning methods have been proposed to enhance the quality of prompts, these methods often face optimization restrictions due to prompt initialization, which can significantly constrain the exploration domain and potentially lead to suboptimal solutions. To eliminate the reliance on the initial prompt, we shift our perspective towards the generative model, framing the prompt-tuning process as a form of conditional generative modeling, where prompts are generated from random noise. Our innovation, the Prompt Diffuser, leverages a conditional diffusion model to produce prompts of exceptional quality. Central to our framework is the approach to trajectory reconstruction and the meticulous integration of downstream task guidance during the training phase. Further experimental results underscore the potency of the Prompt Diffuser as a robust and effective tool for the prompt-tuning process, demonstrating strong performance in the meta-RL tasks.

Xiaoman Zhang, Chaoyi Wu, Ziheng Zhao et al.

Medical Visual Question Answering (MedVQA) presents a significant opportunity to enhance diagnostic accuracy and healthcare delivery by leveraging artificial intelligence to interpret and answer questions based on medical images. In this study, we reframe the problem of MedVQA as a generation task that naturally follows the human-machine interaction and propose a generative-based model for medical visual understanding by aligning visual information from a pre-trained vision encoder with a large language model. We establish a scalable pipeline to construct a large-scale medical visual question-answering dataset, named PMC-VQA, which contains 227k VQA pairs of 149k images that cover various modalities or diseases. We train the proposed model on PMC-VQA and then fine-tune it on multiple public benchmarks, e.g., VQA-RAD, SLAKE, and Image-Clef-2019, significantly outperforming existing MedVQA models in generating relevant, accurate free-form answers. In addition, we propose a test set that has undergone manual verification, which is significantly more challenging, serving to better monitor the development of generative MedVQA methods. To facilitate comprehensive evaluation and comparison, we have maintained a leaderboard at https://paperswithcode.com/paper/pmc-vqa-visual-instruction-tuning-for-medical, offering a centralized resource for tracking progress and benchmarking state-of-the-art approaches. The PMC-VQA dataset emerges as a vital resource for the field of research, and the MedVInT presents a significant breakthrough in the area of MedVQA.

Baohua Sun, Weixiong Lin, Hao Sha et al.

Semantic segmentation is the task to cluster pixels on an image belonging to the same class. It is widely used in the real-world applications including autonomous driving, medical imaging analysis, industrial inspection, smartphone camera for person segmentation and so on. Accelerating the semantic segmentation models on the mobile and edge devices are practical needs for the industry. Recent years have witnessed the wide availability of CNN (Convolutional Neural Networks) accelerators. They have the advantages on power efficiency, inference speed, which are ideal for accelerating the semantic segmentation models on the edge devices. However, the CNN accelerator chips also have the limitations on flexibility and memory. In addition, the CPU load is very critical because the CNN accelerator chip works as a co-processor with a host CPU. In this paper, we optimize the semantic segmentation model in order to fully utilize the limited memory and the supported operators on the CNN accelerator chips, and at the same time reduce the CPU load of the CNN model to zero. The resulting model is called GnetSeg. Furthermore, we propose the integer encoding for the mask of the GnetSeg model, which minimizes the latency of data transfer between the CNN accelerator and the host CPU. The experimental result shows that the model running on the 224mW chip achieves the speed of 318FPS with excellent accuracy for applications such as person segmentation.