Leonard W. T. Ng

Stephen G. Dale, Nikita Kazeev, Alastair J. A. Price et al.

Artificial intelligence and machine learning are reshaping how we approach scientific discovery, not by replacing established methods but by extending what researchers can probe, predict, and design. In this roadmap we provide a forward-looking view of AI-enabled science across biology, chemistry, climate science, mathematics, materials science, physics, self-driving laboratories and unconventional computing. Several shared themes emerge: the need for diverse and trustworthy data, transferable electronic-structure and interatomic models, AI systems integrated into end-to-end scientific workflows that connect simulations to experiments and generative systems grounded in synthesisability rather than purely idealised phases. Across domains, we highlight how large foundation models, active learning and self-driving laboratories can close loops between prediction and validation while maintaining reproducibility and physical interpretability. Taken together, these perspectives outline where AI-enabled science stands today, identify bottlenecks in data, methods and infrastructure, and chart concrete directions for building AI systems that are not only more powerful but also more transparent and capable of accelerating discovery in complex real-world environments.

Lekai Song, Pengyu Liu, Jingfang Pei et al.

The demand for efficient edge vision has spurred the interest in developing stochastic computing approaches for performing image processing tasks. Memristors with inherent stochasticity readily introduce probability into the computations and thus enable stochastic image processing computations. Here, we present a stochastic computing approach for edge detection, a fundamental image processing technique, facilitated with memristor-enabled stochastic logics. Specifically, we integrate the memristors with logic circuits and harness the stochasticity from the memristors to realize compact stochastic logics for stochastic number encoding and processing. The stochastic numbers, exhibiting well-regulated probabilities and correlations, can be processed to perform logic operations with statistical probabilities. This can facilitate lightweight stochastic edge detection for edge visual scenarios characterized with high-level noise errors. As a practical demonstration, we implement a hardware stochastic Roberts cross operator using the stochastic logics, and prove its exceptional edge detection performance, remarkably, with 95% less computational cost while withstanding 50% bit-flip errors. The results underscore the great potential of our stochastic edge detection approach in developing lightweight, error-tolerant edge vision hardware and systems for autonomous driving, virtual/augmented reality, medical imaging diagnosis, industrial automation, and beyond.

Lekai Song, Pengyu Liu, Yang Liu et al.

Brains perform decision-making by Bayes theorem. The theorem quantifies events as probabilities and, based on probability rules, renders the decisions. Learning from this, Bayes theorem can be applied to enable efficient user-scene interactions. However, given the probabilistic nature, implementing Bayes theorem in hardware using conventional deterministic computing can incur excessive computational cost and decision latency. Though challenging, here we present a probabilistic computing approach based on memristors to implement the Bayes theorem. We integrate memristors with Boolean logics and, by exploiting the volatile stochastic switching of the memristors, realise probabilistic logic operations, key for hardware Bayes theorem implementation. To empirically validate the efficacy of the hardware Bayes theorem in user-scene interactions, we develop lightweight Bayesian inference and fusion hardware operators using the probabilistic logics and apply the operators in road scene parsing for self-driving, including route planning and obstacle detection. The results show our operators can achieve reliable decisions in less than 0.4 ms (or equivalently 2,500 fps), outperforming human decision-making and the existing driving assistance systems.

Maung Thway, Jose Recatala-Gomez, Fun Siong Lim et al.

Generative artificial intelligence (GenAI) and large language models (LLMs) have simultaneously opened new avenues for enhancing human learning and increased the prevalence of poor-quality information in student response - termed Botpoop. This study introduces Professor Leodar, a custom-built, Singlish-speaking Retrieval Augmented Generation (RAG) chatbot designed to enhance educational while reducing Botpoop. Deployed at Nanyang Technological University, Singapore, Professor Leodar offers a glimpse into the future of AI-assisted learning, offering personalized guidance, 24/7 availability, and contextually relevant information. Through a mixed-methods approach, we examine the impact of Professor Leodar on learning, engagement, and exam preparedness, with 97.1% of participants reporting positive experiences. These findings help define possible roles of AI in education and highlight the potential of custom GenAI chatbots. Our combination of chatbot development, in-class deployment and outcomes study offers a benchmark for GenAI educational tools and is a stepping stone for redefining the interplay between AI and human learning.