Liang Wan

Zhaohu Xing, Liang Wan, Huazhu Fu et al.

In recent years, Denoising Diffusion Models have demonstrated remarkable success in generating semantically valuable pixel-wise representations for image generative modeling. In this study, we propose a novel end-to-end framework, called Diff-UNet, for medical volumetric segmentation. Our approach integrates the diffusion model into a standard U-shaped architecture to extract semantic information from the input volume effectively, resulting in excellent pixel-level representations for medical volumetric segmentation. To enhance the robustness of the diffusion model's prediction results, we also introduce a Step-Uncertainty based Fusion (SUF) module during inference to combine the outputs of the diffusion models at each step. We evaluate our method on three datasets, including multimodal brain tumors in MRI, liver tumors, and multi-organ CT volumes, and demonstrate that Diff-UNet outperforms other state-of-the-art methods significantly. Our experimental results also indicate the universality and effectiveness of the proposed model. The proposed framework has the potential to facilitate the accurate diagnosis and treatment of medical conditions by enabling more precise segmentation of anatomical structures. The codes of Diff-UNet are available at https://github.com/ge-xing/Diff-UNet

Zhaohu Xing, Lequan Yu, Liang Wan et al.

Multi-modal MR imaging is routinely used in clinical practice to diagnose and investigate brain tumors by providing rich complementary information. Previous multi-modal MRI segmentation methods usually perform modal fusion by concatenating multi-modal MRIs at an early/middle stage of the network, which hardly explores non-linear dependencies between modalities. In this work, we propose a novel Nested Modality-Aware Transformer (NestedFormer) to explicitly explore the intra-modality and inter-modality relationships of multi-modal MRIs for brain tumor segmentation. Built on the transformer-based multi-encoder and single-decoder structure, we perform nested multi-modal fusion for high-level representations of different modalities and apply modality-sensitive gating (MSG) at lower scales for more effective skip connections. Specifically, the multi-modal fusion is conducted in our proposed Nested Modality-aware Feature Aggregation (NMaFA) module, which enhances long-term dependencies within individual modalities via a tri-orientated spatial-attention transformer, and further complements key contextual information among modalities via a cross-modality attention transformer. Extensive experiments on BraTS2020 benchmark and a private meningiomas segmentation (MeniSeg) dataset show that the NestedFormer clearly outperforms the state-of-the-arts. The code is available at https://github.com/920232796/NestedFormer.

Zhaohu Xing, Lei Zhu, Lequan Yu et al.

Masked image modeling (MIM) with transformer backbones has recently been exploited as a powerful self-supervised pre-training technique. The existing MIM methods adopt the strategy to mask random patches of the image and reconstruct the missing pixels, which only considers semantic information at a lower level, and causes a long pre-training time.This paper presents HybridMIM, a novel hybrid self-supervised learning method based on masked image modeling for 3D medical image segmentation.Specifically, we design a two-level masking hierarchy to specify which and how patches in sub-volumes are masked, effectively providing the constraints of higher level semantic information. Then we learn the semantic information of medical images at three levels, including:1) partial region prediction to reconstruct key contents of the 3D image, which largely reduces the pre-training time burden (pixel-level); 2) patch-masking perception to learn the spatial relationship between the patches in each sub-volume (region-level).and 3) drop-out-based contrastive learning between samples within a mini-batch, which further improves the generalization ability of the framework (sample-level). The proposed framework is versatile to support both CNN and transformer as encoder backbones, and also enables to pre-train decoders for image segmentation. We conduct comprehensive experiments on four widely-used public medical image segmentation datasets, including BraTS2020, BTCV, MSD Liver, and MSD Spleen. The experimental results show the clear superiority of HybridMIM against competing supervised methods, masked pre-training approaches, and other self-supervised methods, in terms of quantitative metrics, timing performance and qualitative observations. The codes of HybridMIM are available at https://github.com/ge-xing/HybridMIM

Zhijin Ge, Fanhua Shang, Hongying Liu et al.

Deep neural networks are vulnerable to adversarial examples crafted by applying human-imperceptible perturbations on clean inputs. Although many attack methods can achieve high success rates in the white-box setting, they also exhibit weak transferability in the black-box setting. Recently, various methods have been proposed to improve adversarial transferability, in which the input transformation is one of the most effective methods. In this work, we notice that existing input transformation-based works mainly adopt the transformed data in the same domain for augmentation. Inspired by domain generalization, we aim to further improve the transferability using the data augmented from different domains. Specifically, a style transfer network can alter the distribution of low-level visual features in an image while preserving semantic content for humans. Hence, we propose a novel attack method named Style Transfer Method (STM) that utilizes a proposed arbitrary style transfer network to transform the images into different domains. To avoid inconsistent semantic information of stylized images for the classification network, we fine-tune the style transfer network and mix up the generated images added by random noise with the original images to maintain semantic consistency and boost input diversity. Extensive experimental results on the ImageNet-compatible dataset show that our proposed method can significantly improve the adversarial transferability on either normally trained models or adversarially trained models than state-of-the-art input transformation-based attacks. Code is available at: https://github.com/Zhijin-Ge/STM.

Tianling Liu, Wennan Liu, Lequan Yu et al.

Preoperative and noninvasive prediction of the meningioma grade is important in clinical practice, as it directly influences the clinical decision making. What's more, brain invasion in meningioma (i.e., the presence of tumor tissue within the adjacent brain tissue) is an independent criterion for the grading of meningioma and influences the treatment strategy. Although efforts have been reported to address these two tasks, most of them rely on hand-crafted features and there is no attempt to exploit the two prediction tasks simultaneously. In this paper, we propose a novel task-aware contrastive learning algorithm to jointly predict meningioma grade and brain invasion from multi-modal MRIs. Based on the basic multi-task learning framework, our key idea is to adopt contrastive learning strategy to disentangle the image features into task-specific features and task-common features, and explicitly leverage their inherent connections to improve feature representation for the two prediction tasks. In this retrospective study, an MRI dataset was collected, for which 800 patients (containing 148 high-grade, 62 invasion) were diagnosed with meningioma by pathological analysis. Experimental results show that the proposed algorithm outperforms alternative multi-task learning methods, achieving AUCs of 0:8870 and 0:9787 for the prediction of meningioma grade and brain invasion, respectively. The code is available at https://github.com/IsDling/predictTCL.

Zhihao Chen, Yang Zhou, Anh Tran et al.

Medical phrase grounding (MPG) aims to locate the most relevant region in a medical image, given a phrase query describing certain medical findings, which is an important task for medical image analysis and radiological diagnosis. However, existing visual grounding methods rely on general visual features for identifying objects in natural images and are not capable of capturing the subtle and specialized features of medical findings, leading to sub-optimal performance in MPG. In this paper, we propose MedRPG, an end-to-end approach for MPG. MedRPG is built on a lightweight vision-language transformer encoder and directly predicts the box coordinates of mentioned medical findings, which can be trained with limited medical data, making it a valuable tool in medical image analysis. To enable MedRPG to locate nuanced medical findings with better region-phrase correspondences, we further propose Tri-attention Context contrastive alignment (TaCo). TaCo seeks context alignment to pull both the features and attention outputs of relevant region-phrase pairs close together while pushing those of irrelevant regions far away. This ensures that the final box prediction depends more on its finding-specific regions and phrases. Experimental results on three MPG datasets demonstrate that our MedRPG outperforms state-of-the-art visual grounding approaches by a large margin. Additionally, the proposed TaCo strategy is effective in enhancing finding localization ability and reducing spurious region-phrase correlations.

Zhihao Chen, Liang Wan, Yefan Xiao et al.

Shadow removal in a single image has received increasing attention in recent years. However, removing shadows over dynamic scenes remains largely under-explored. In this paper, we propose the first data-driven video shadow removal model, termed PSTNet, by exploiting three essential characteristics of video shadows, i.e., physical property, spatio relation, and temporal coherence. Specifically, a dedicated physical branch was established to conduct local illumination estimation, which is more applicable for scenes with complex lighting and textures, and then enhance the physical features via a mask-guided attention strategy. Then, we develop a progressive aggregation module to enhance the spatio and temporal characteristics of features maps, and effectively integrate the three kinds of features. Furthermore, to tackle the lack of datasets of paired shadow videos, we synthesize a dataset (SVSRD-85) with aid of the popular game GTAV by controlling the switch of the shadow renderer. Experiments against 9 state-of-the-art models, including image shadow removers and image/video restoration methods, show that our method improves the best SOTA in terms of RMSE error for the shadow area by 14.7. In addition, we develop a lightweight model adaptation strategy to make our synthetic-driven model effective in real world scenes. The visual comparison on the public SBU-TimeLapse dataset verifies the generalization ability of our model in real scenes.

Qing Sun, Fan Lyu, Fanhua Shang et al.

Continual Learning (CL) sequentially learns new tasks like human beings, with the goal to achieve better Stability (S, remembering past tasks) and Plasticity (P, adapting to new tasks). Due to the fact that past training data is not available, it is valuable to explore the influence difference on S and P among training examples, which may improve the learning pattern towards better SP. Inspired by Influence Function (IF), we first study example influence via adding perturbation to example weight and computing the influence derivation. To avoid the storage and calculation burden of Hessian inverse in neural networks, we propose a simple yet effective MetaSP algorithm to simulate the two key steps in the computation of IF and obtain the S- and P-aware example influence. Moreover, we propose to fuse two kinds of example influence by solving a dual-objective optimization problem, and obtain a fused influence towards SP Pareto optimality. The fused influence can be used to control the update of model and optimize the storage of rehearsal. Empirical results show that our algorithm significantly outperforms state-of-the-art methods on both task- and class-incremental benchmark CL datasets.

Tianling Liu, Hongying Liu, Fanhua Shang et al.

Multimodal MRIs play a crucial role in clinical diagnosis and treatment. Feature disentanglement (FD)-based methods, aiming at learning superior feature representations for multimodal data analysis, have achieved significant success in multimodal learning (MML). Typically, existing FD-based methods separate multimodal data into modality-shared and modality-specific features, and employ concatenation or attention mechanisms to integrate these features. However, our preliminary experiments indicate that these methods could lead to a loss of shared information among subsets of modalities when the inputs contain more than two modalities, and such information is critical for prediction accuracy. Furthermore, these methods do not adequately interpret the relationships between the decoupled features at the fusion stage. To address these limitations, we propose a novel Complete Feature Disentanglement (CFD) strategy that recovers the lost information during feature decoupling. Specifically, the CFD strategy not only identifies modality-shared and modality-specific features, but also decouples shared features among subsets of multimodal inputs, termed as modality-partial-shared features. We further introduce a new Dynamic Mixture-of-Experts Fusion (DMF) module that dynamically integrates these decoupled features, by explicitly learning the local-global relationships among the features. The effectiveness of our approach is validated through classification tasks on three multimodal MRI datasets. Extensive experimental results demonstrate that our approach outperforms other state-of-the-art MML methods with obvious margins, showcasing its superior performance.

Weiqi Li, Fan Lyu, Fanhua Shang et al.

Real-world data is extremely imbalanced and presents a long-tailed distribution, resulting in models that are biased towards classes with sufficient samples and perform poorly on rare classes. Recent methods propose to rebalance classes but they undertake the seesaw dilemma (what is increasing performance on tail classes may decrease that of head classes, and vice versa). In this paper, we argue that the seesaw dilemma is derived from gradient imbalance of different classes, in which gradients of inappropriate classes are set to important for updating, thus are prone to overcompensation or undercompensation on tail classes. To achieve ideal compensation, we formulate the long-tailed recognition as an multi-objective optimization problem, which fairly respects the contributions of head and tail classes simultaneously. For efficiency, we propose a Gradient-Balancing Grouping (GBG) strategy to gather the classes with similar gradient directions, thus approximately make every update under a Pareto descent direction. Our GBG method drives classes with similar gradient directions to form more representative gradient and provide ideal compensation to the tail classes. Moreover, We conduct extensive experiments on commonly used benchmarks in long-tailed learning and demonstrate the superiority of our method over existing SOTA methods.

Lianyu Hu, Fanhua Shang, Liang Wan et al.

In this paper, we introduce iLLaVA, a simple method that can be seamlessly deployed upon current Large Vision-Language Models (LVLMs) to greatly increase the throughput with nearly lossless model performance, without a further requirement to train. iLLaVA achieves this by finding and gradually merging the redundant tokens with an accurate and fast algorithm, which can merge hundreds of tokens within only one step. While some previous methods have explored directly pruning or merging tokens in the inference stage to accelerate models, our method excels in both performance and throughput by two key designs. First, while most previous methods only try to save the computations of Large Language Models (LLMs), our method accelerates the forward pass of both image encoders and LLMs in LVLMs, which both occupy a significant part of time during inference. Second, our method recycles the beneficial information from the pruned tokens into existing tokens, which avoids directly dropping context tokens like previous methods to cause performance loss. iLLaVA can nearly 2$\times$ the throughput, and reduce the memory costs by half with only a 0.2\% - 0.5\% performance drop across models of different scales including 7B, 13B and 34B. On tasks across different domains including single-image, multi-images and videos, iLLaVA demonstrates strong generalizability with consistently promising efficiency. We finally offer abundant visualizations to show the merging processes of iLLaVA in each step, which show insights into the distribution of computing resources in LVLMs. Code is available at https://github.com/hulianyuyy/iLLaVA.

Fan Lyu, Wei Feng, Yuepan Li et al.

The goal of Continual Learning (CL) is to continuously learn from new data streams and accomplish the corresponding tasks. Previously studied CL assumes that data are given in sequence nose-to-tail for different tasks, thus indeed belonging to Serial Continual Learning (SCL). This paper studies the novel paradigm of Parallel Continual Learning (PCL) in dynamic multi-task scenarios, where a diverse set of tasks is encountered at different time points. PCL presents challenges due to the training of an unspecified number of tasks with varying learning progress, leading to the difficulty of guaranteeing effective model updates for all encountered tasks. In our previous conference work, we focused on measuring and reducing the discrepancy among gradients in a multi-objective optimization problem, which, however, may still contain negative transfers in every model update. To address this issue, in the dynamic multi-objective optimization problem, we introduce task-specific elastic factors to adjust the descent direction towards the Pareto front. The proposed method, called Elastic Multi-Gradient Descent (EMGD), ensures that each update follows an appropriate Pareto descent direction, minimizing any negative impact on previously learned tasks. To balance the training between old and new tasks, we also propose a memory editing mechanism guided by the gradient computed using EMGD. This editing process updates the stored data points, reducing interference in the Pareto descent direction from previous tasks. Experiments on public datasets validate the effectiveness of our EMGD in the PCL setting.

Hongmei Yin, Tingliang Feng, Fan Lyu et al.

In this work, we focus on continual semantic segmentation (CSS), where segmentation networks are required to continuously learn new classes without erasing knowledge of previously learned ones. Although storing images of old classes and directly incorporating them into the training of new models has proven effective in mitigating catastrophic forgetting in classification tasks, this strategy presents notable limitations in CSS. Specifically, the stored and new images with partial category annotations leads to confusion between unannotated categories and the background, complicating model fitting. To tackle this issue, this paper proposes a novel Enhanced Instance Replay (EIR) method, which not only preserves knowledge of old classes while simultaneously eliminating background confusion by instance storage of old classes, but also mitigates background shifts in the new images by integrating stored instances with new images. By effectively resolving background shifts in both stored and new images, EIR alleviates catastrophic forgetting in the CSS task, thereby enhancing the model's capacity for CSS. Experimental results validate the efficacy of our approach, which significantly outperforms state-of-the-art CSS methods.

Jiaxi Li, Di Lin, Hao Chen et al.

Deep neural networks (DNNs) often struggle with out-of-distribution data, limiting their reliability in diverse realworld applications. To address this issue, domain generalization methods have been developed to learn domain-invariant features from single or multiple training domains, enabling generalization to unseen testing domains. However, existing approaches usually overlook the impact of style frequency within the training set. This oversight predisposes models to capture spurious visual correlations caused by style confounding factors, rather than learning truly causal representations, thereby undermining inference reliability. In this work, we introduce Style Deconfounding Causal Learning (SDCL), a novel causal inference-based framework designed to explicitly address style as a confounding factor. Our approaches begins with constructing a structural causal model (SCM) tailored to the domain generalization problem and applies a backdoor adjustment strategy to account for style influence. Building on this foundation, we design a style-guided expert module (SGEM) to adaptively clusters style distributions during training, capturing the global confounding style. Additionally, a back-door causal learning module (BDCL) performs causal interventions during feature extraction, ensuring fair integration of global confounding styles into sample predictions, effectively reducing style bias. The SDCL framework is highly versatile and can be seamlessly integrated with state-of-the-art data augmentation techniques. Extensive experiments across diverse natural and medical image recognition tasks validate its efficacy, demonstrating superior performance in both multi-domain and the more challenging single-domain generalization scenarios.