Hongfeng Li

Jiayi Xie, Hongfeng Li, Jin Cheng et al.

The brain extracellular space (ECS), an irregular, extremely tortuous nanoscale space located between cells or between cells and blood vessels, is crucial for nerve cell survival. It plays a pivotal role in high-level brain functions such as memory, emotion, and sensation. However, the specific form of molecular transport within the ECS remain elusive. To address this challenge, this paper proposes a novel approach to quantitatively analyze the molecular transport within the ECS by solving an inverse problem derived from the advection-diffusion equation (ADE) using a physics-informed neural network (PINN). PINN provides a streamlined solution to the ADE without the need for intricate mathematical formulations or grid settings. Additionally, the optimization of PINN facilitates the automatic computation of the diffusion coefficient governing long-term molecule transport and the velocity of molecules driven by advection. Consequently, the proposed method allows for the quantitative analysis and identification of the specific pattern of molecular transport within the ECS through the calculation of the Peclet number. Experimental validation on two datasets of magnetic resonance images (MRIs) captured at different time points showcases the effectiveness of the proposed method. Notably, our simulations reveal identical molecular transport patterns between datasets representing rats with tracer injected into the same brain region. These findings highlight the potential of PINN as a promising tool for comprehensively exploring molecular transport within the ECS.

Hongfeng Li

Image classification is a challenging problem for computer in reality. Large numbers of methods can achieve satisfying performances with sufficient labeled images. However, labeled images are still highly limited for certain image classification tasks. Instead, lots of unlabeled images are available and easy to be obtained. Therefore, making full use of the available unlabeled data can be a potential way to further improve the performance of current image classification methods. In this paper, we propose a discriminative semi-supervised sparse representation algorithm for image classification. In the algorithm, the classification process is combined with the sparse coding to learn a data-driven linear classifier. To obtain discriminative predictions, the predicted labels are regularized with three graphs, i.e., the global manifold structure graph, the within-class graph and the between-classes graph. The constructed graphs are able to extract structure information included in both the labeled and unlabeled data. Moreover, the proposed method is extended to a kernel version for dealing with data that cannot be linearly classified. Accordingly, efficient algorithms are developed to solve the corresponding optimization problems. Experimental results on several challenging databases demonstrate that the proposed algorithm achieves excellent performances compared with related popular methods.

Jie Zhao, Quanzheng Li, Xiang Li et al.

Pap smear testing has been widely used for detecting cervical cancers based on the morphology properties of cell nuclei in microscopic image. An accurate nuclei segmentation could thus improve the success rate of cervical cancer screening. In this work, a method of automated cervical nuclei segmentation using Deformable Multipath Ensemble Model (D-MEM) is proposed. The approach adopts a U-shaped convolutional network as a backbone network, in which dense blocks are used to transfer feature information more effectively. To increase the flexibility of the model, we then use deformable convolution to deal with different nuclei irregular shapes and sizes. To reduce the predictive bias, we further construct multiple networks with different settings, which form an ensemble model. The proposed segmentation framework has achieved state-of-the-art accuracy on Herlev dataset with Zijdenbos similarity index (ZSI) of 0.933, and has the potential to be extended for solving other medical image segmentation tasks.