Ni Zhang

Yongqi Liang, Qidong Liu, Chunze Yang et al. · tsinghua

Electronic health records (EHRs) are central to clinical prediction, but existing methods either rely on correlation-driven deep models or use single large language models (LLMs), making it difficult to support multidisciplinary clinical reasoning. Recent multi-agent systems (MAS) provide a promising alternative, yet current EHR-grounded MAS methods still suffer from weak evidence differentiation across agents and redundant multi-round interaction. We propose D2MDT, a Department-aware MultiDisciplinary Team Consultation with Deliberation for Efficient clinical prediction. D2MDT first constructs structured EHR evidence and consultation-ready semantic evidence for multi-agent consultation. It then assigns patient-specific department perspectives to doctor agents and retrieves complementary evidence for collaborative consultation. To improve efficiency, D2MDT further introduces residual deliberation, which updates only unresolved consensus rather than replaying the full discussion history. Finally, D2MDT fuses the refined consensus report with structured EHR representations for prediction. Experiments on mortality prediction show that D2MDT improves both predictive performance and consultation efficiency. We release the code online to ease the reproducibility of this paper.

Long Li, Junwei Han, Ni Zhang et al.

Most previous co-salient object detection works mainly focus on extracting co-salient cues via mining the consistency relations across images while ignoring explicit exploration of background regions. In this paper, we propose a Discriminative co-saliency and background Mining Transformer framework (DMT) based on several economical multi-grained correlation modules to explicitly mine both co-saliency and background information and effectively model their discrimination. Specifically, we first propose a region-to-region correlation module for introducing inter-image relations to pixel-wise segmentation features while maintaining computational efficiency. Then, we use two types of pre-defined tokens to mine co-saliency and background information via our proposed contrast-induced pixel-to-token correlation and co-saliency token-to-token correlation modules. We also design a token-guided feature refinement module to enhance the discriminability of the segmentation features under the guidance of the learned tokens. We perform iterative mutual promotion for the segmentation feature extraction and token construction. Experimental results on three benchmark datasets demonstrate the effectiveness of our proposed method. The source code is available at: https://github.com/dragonlee258079/DMT.

Jian Shi, Pengyi Zhang, Ni Zhang et al.

Medical imaging often contains critical fine-grained features, such as tumors or hemorrhages, crucial for diagnosis yet potentially too subtle for detection with conventional methods. In this paper, we introduce \textit{DIA}, dissolving is amplifying. DIA is a fine-grained anomaly detection framework for medical images. First, we introduce \textit{dissolving transformations}. We employ diffusion with a generative diffusion model as a dedicated feature-aware denoiser. Applying diffusion to medical images in a certain manner can remove or diminish fine-grained discriminative features. Second, we introduce an \textit{amplifying framework} based on contrastive learning to learn a semantically meaningful representation of medical images in a self-supervised manner, with a focus on fine-grained features. The amplifying framework contrasts additional pairs of images with and without dissolving transformations applied and thereby emphasizes the dissolved fine-grained features. DIA significantly improves the medical anomaly detection performance with around 18.40\% AUC boost against the baseline method and achieves an overall SOTA against other benchmark methods. Our code is available at \url{https://github.com/shijianjian/DIA.git}.

Chunze Yang, Qidong Liu, Wenjie Zhao et al.

Whole-slide image visual question answering (WSI-VQA) frames pathology as an extreme-context search problem: to answer a free-form clinical query, a system must first navigate a gigapixel slide under a strict inspection budget to locate sparse, high-resolution evidence. Existing approaches largely fall into two paradigms: i) supervised pathology multimodal large language models (MLLMs) and agents can absorb localization and reasoning into learned modules, but they often couple navigation to task-specific supervision and retraining, limiting their practicality; ii) training-free pathology agents avoid this cost by keeping core models frozen, but often follow a question-first design, constructing the initial candidate set mainly from query-conditioned relevance. This can miss decisive morphology that is not named in the question, and force heavier inference-time scaffolding. To address this challenge, we introduce PathNavigate, a training-free pathology agent built around a scan-search-readout routine. Before question matching, PathNavigate scans the current slide at low magnification with a shared online memory module over frozen pathology features, producing a slide-specific surprise field that marks an abnormal-region pool. It then applies question-conditioned PLIP relevance only within this pool to select high-magnification search targets. Finally, it extracts local high-magnification evidence and answers with a frozen perceptor-adjudicator stack, using the same online memory as slide-level context. Experiments on WSI-VQA and SlideBench-BCNB show that the proposed scan-search-readout design improves answer accuracy and yields more interpretable evidence-selection trajectories with higher efficiency.The code is available online.

Nian Liu, Ziyang Luo, Ni Zhang et al.

While previous CNN-based models have exhibited promising results for salient object detection (SOD), their ability to explore global long-range dependencies is restricted. Our previous work, the Visual Saliency Transformer (VST), addressed this constraint from a transformer-based sequence-to-sequence perspective, to unify RGB and RGB-D SOD. In VST, we developed a multi-task transformer decoder that concurrently predicts saliency and boundary outcomes in a pure transformer architecture. Moreover, we introduced a novel token upsampling method called reverse T2T for predicting a high-resolution saliency map effortlessly within transformer-based structures. Building upon the VST model, we further propose an efficient and stronger VST version in this work, i.e. VST++. To mitigate the computational costs of the VST model, we propose a Select-Integrate Attention (SIA) module, partitioning foreground into fine-grained segments and aggregating background information into a single coarse-grained token. To incorporate 3D depth information with low cost, we design a novel depth position encoding method tailored for depth maps. Furthermore, we introduce a token-supervised prediction loss to provide straightforward guidance for the task-related tokens. We evaluate our VST++ model across various transformer-based backbones on RGB, RGB-D, and RGB-T SOD benchmark datasets. Experimental results show that our model outperforms existing methods while achieving a 25% reduction in computational costs without significant performance compromise. The demonstrated strong ability for generalization, enhanced performance, and heightened efficiency of our VST++ model highlight its potential.

Jiusong Ge, Yingkang Zhan, Wenjie Zhao et al.

Traditional whole slide image (WSI) analysis methods typically rely on the multiple instance learning (MIL) paradigm, which extracts patch-level features at high magnification and aggregates them for slide-level prediction. However, such exhaustive patch-level processing is computationally expensive, severely limiting the efficiency and scalability of WSI analysis. To address this challenge, we propose PathCTM (a Pathology-oriented Continuous Thought Model) that enables token-efficient scale-space continuous reasoning for gigapixel WSIs. PathCTM formulates diagnostic inference as a dynamic sequential information pursuit. It progressively transitions from low-magnification global to high-magnification local inspection, and adaptively terminates inference when sufficient evidence is gathered to effectively bound decision uncertainty. Specifically, it uses conditional computation for dynamic scale switching with attention-guided region pruning, coupled with confidence-aware early stopping. Extensive experiments demonstrate that, compared with standard MIL-based methods, PathCTM reduces the number of required image patches by 95.95% and shortens inference time by approximately 95.62%, while maintaining AUC without degradation. Code is available at https://github.com/JSGe-AI/PathCTM.

Jian Shi, Ni Zhang

Anomaly detection suffered from the lack of anomalies due to the diversity of abnormalities and the difficulties of obtaining large-scale anomaly data. Semi-supervised anomaly detection methods are often used to solely leverage normal data to detect abnormalities that deviated from the learnt normality distributions. Meanwhile, given the fact that limited anomaly data can be obtained with a minor cost in practice, some researches also investigated anomaly detection methods under supervised scenarios with limited anomaly data. In order to address the lack of abnormal data for robust anomaly detection, we propose Adversarial Generative Anomaly Detection (AGAD), a self-contrast-based anomaly detection paradigm that learns to detect anomalies by generating \textit{contextual adversarial information} from the massive normal examples. Essentially, our method generates pseudo-anomaly data for both supervised and semi-supervised anomaly detection scenarios. Extensive experiments are carried out on multiple benchmark datasets and real-world datasets, the results show significant improvement in both supervised and semi-supervised scenarios. Importantly, our approach is data-efficient that can boost up the detection accuracy with no more than 5% anomalous training data.

Ni Zhang, Junwei Han, Nian Liu et al.

Humans perform co-saliency detection by first summarizing the consensus knowledge in the whole group and then searching corresponding objects in each image. Previous methods usually lack robustness, scalability, or stability for the first process and simply fuse consensus features with image features for the second process. In this paper, we propose a novel consensus-aware dynamic convolution model to explicitly and effectively perform the "summarize and search" process. To summarize consensus image features, we first summarize robust features for every single image using an effective pooling method and then aggregate cross-image consensus cues via the self-attention mechanism. By doing this, our model meets the scalability and stability requirements. Next, we generate dynamic kernels from consensus features to encode the summarized consensus knowledge. Two kinds of kernels are generated in a supplementary way to summarize fine-grained image-specific consensus object cues and the coarse group-wise common knowledge, respectively. Then, we can effectively perform object searching by employing dynamic convolution at multiple scales. Besides, a novel and effective data synthesis method is also proposed to train our network. Experimental results on four benchmark datasets verify the effectiveness of our proposed method. Our code and saliency maps are available at \url{https://github.com/nnizhang/CADC}.

Nian Liu, Ni Zhang, Kaiyuan Wan et al.

Existing state-of-the-art saliency detection methods heavily rely on CNN-based architectures. Alternatively, we rethink this task from a convolution-free sequence-to-sequence perspective and predict saliency by modeling long-range dependencies, which can not be achieved by convolution. Specifically, we develop a novel unified model based on a pure transformer, namely, Visual Saliency Transformer (VST), for both RGB and RGB-D salient object detection (SOD). It takes image patches as inputs and leverages the transformer to propagate global contexts among image patches. Unlike conventional architectures used in Vision Transformer (ViT), we leverage multi-level token fusion and propose a new token upsampling method under the transformer framework to get high-resolution detection results. We also develop a token-based multi-task decoder to simultaneously perform saliency and boundary detection by introducing task-related tokens and a novel patch-task-attention mechanism. Experimental results show that our model outperforms existing methods on both RGB and RGB-D SOD benchmark datasets. Most importantly, our whole framework not only provides a new perspective for the SOD field but also shows a new paradigm for transformer-based dense prediction models. Code is available at https://github.com/nnizhang/VST.

Ni Zhang, Jingfeng Yang, Zhiguang Cao et al.

Recent research into solving vehicle routing problems (VRPs) has gained significant traction, particularly through the application of deep (reinforcement) learning for end-to-end solution construction. However, many current construction-based neural solvers predominantly utilize Transformer architectures, which can face scalability challenges and struggle to produce diverse solutions. To address these limitations, we introduce a novel framework beyond Transformer-based approaches, i.e., Adversarial Generative Flow Networks (AGFN). This framework integrates the generative flow network (GFlowNet)-a probabilistic model inherently adept at generating diverse solutions (routes)-with a complementary model for discriminating (or evaluating) the solutions. These models are trained alternately in an adversarial manner to improve the overall solution quality, followed by a proposed hybrid decoding method to construct the solution. We apply the AGFN framework to solve the capacitated vehicle routing problem (CVRP) and travelling salesman problem (TSP), and our experimental results demonstrate that AGFN surpasses the popular construction-based neural solvers, showcasing strong generalization capabilities on synthetic and real-world benchmark instances.

Ni Zhang, Zhiguang Cao, Jianan Zhou et al.

Complex vehicle routing problems (VRPs) remain a fundamental challenge, demanding substantial expert effort for intent interpretation and algorithm design. While large language models (LLMs) offer a promising path toward automation, current approaches still rely on external intervention, which restrict autonomy and often lead to execution errors and low solution feasibility. To address these challenges, we propose an Agentic Framework with LLMs (AFL) for solving complex vehicle routing problems, achieving full automation from problem instance to solution. AFL directly extracts knowledge from raw inputs and enables self-contained code generation without handcrafted modules or external solvers. To improve trustworthiness, AFL decomposes the overall pipeline into three manageable subtasks and employs four specialized agents whose coordinated interactions enforce cross-functional consistency and logical soundness. Extensive experiments on 60 complex VRPs, ranging from standard benchmarks to practical variants, validate the effectiveness and generality of our framework, showing comparable performance against meticulously designed algorithms. Notably, it substantially outperforms existing LLM-based baselines in both code reliability and solution feasibility, achieving rates close to 100% on the evaluated benchmarks.

Ni Zhang, Zhiguang Cao

Existing GFlowNet-based methods for vehicle routing problems (VRPs) typically employ Trajectory Balance (TB) to achieve global optimization but often neglect important aspects of local optimization. While Detailed Balance (DB) addresses local optimization more effectively, it alone falls short in solving VRPs, which inherently require holistic trajectory optimization. To address these limitations, we introduce the Hybrid-Balance GFlowNet (HBG) framework, which uniquely integrates TB and DB in a principled and adaptive manner by aligning their intrinsically complementary strengths. Additionally, we propose a specialized inference strategy for depot-centric scenarios like the Capacitated Vehicle Routing Problem (CVRP), leveraging the depot node's greater flexibility in selecting successors. Despite this specialization, HBG maintains broad applicability, extending effectively to problems without explicit depots, such as the Traveling Salesman Problem (TSP). We evaluate HBG by integrating it into two established GFlowNet-based solvers, i.e., AGFN and GFACS, and demonstrate consistent and significant improvements across both CVRP and TSP, underscoring the enhanced solution quality and generalization afforded by our approach.

Nian Liu, Ni Zhang, Ling Shao et al.

How to effectively fuse cross-modal information is the key problem for RGB-D salient object detection. Early fusion and the result fusion schemes fuse RGB and depth information at the input and output stages, respectively, hence incur the problem of distribution gap or information loss. Many models use the feature fusion strategy but are limited by the low-order point-to-point fusion methods. In this paper, we propose a novel mutual attention model by fusing attention and contexts from different modalities. We use the non-local attention of one modality to propagate long-range contextual dependencies for the other modality, thus leveraging complementary attention cues to perform high-order and trilinear cross-modal interaction. We also propose to induce contrast inference from the mutual attention and obtain a unified model. Considering low-quality depth data may detriment the model performance, we further propose selective attention to reweight the added depth cues. We embed the proposed modules in a two-stream CNN for RGB-D SOD. Experimental results have demonstrated the effectiveness of our proposed model. Moreover, we also construct a new challenging large-scale RGB-D SOD dataset with high-quality, thus can both promote the training and evaluation of deep models.