Guang Yang

Mingcheng Qu, Guang Yang, Donglin Di et al.

Multimodal pathology-genomic analysis is critical for cancer survival prediction. However, existing approaches predominantly integrate formalin-fixed paraffin-embedded (FFPE) slides with genomic data, while neglecting the availability of other preservation slides, such as Fresh Froze (FF) slides. Moreover, as the high-resolution spatial nature of pathology data tends to dominate the cross-modality fusion process, it hinders effective multimodal fusion and leads to modality imbalance challenges between pathology and genomics. These methods also typically require complete data modalities, limiting their clinical applicability with incomplete modalities, such as missing either pathology or genomic data. In this paper, we propose a multimodal survival prediction framework that leverages hypergraph learning to effectively integrate multi-WSI information and cross-modality interactions between pathology slides and genomics data while addressing modality imbalance. In addition, we introduce a memory mechanism that stores previously learned paired pathology-genomic features and dynamically compensates for incomplete modalities. Experiments on five TCGA datasets demonstrate that our model outperforms advanced methods by over 2.3% in C-Index. Under incomplete modality scenarios, our approach surpasses pathology-only (3.3%) and gene-only models (7.9%). Code: https://github.com/MCPathology/M2Surv

Guang Yang, Yujie Zhu

Pre-trained language models (PLMs) are increasingly being applied to code-related tasks. Although PLMs have achieved good results, they do not take into account potential high-order data correlations within the code. We propose three types of high-order correlations in code tokens, i.e. abstract syntax tree family correlation, lexical correlation, and line correlation. We design a tokens and hyperedges generator to capture these high-order data correlations. We improve the architecture of hypergraph neural networks and combine it with adapter tuning to propose a novel hypergraph-based adapter (HGAdapter) to fine-tune PLMs. HGAdapter can encode high-order data correlations and is allowed to be inserted into various PLMs to enhance performance. Experiments were conducted on several public datasets, including six languages of code summarization and code clone detection tasks. Our methods improved the performance of PLMs in datasets to varying degrees. Experimental results validate the introduction of high-order data correlations that contribute to improved effectiveness.