Yan Leng

Emanuele Rossi, Federico Monti, Yan Leng et al.

Strategic interactions between a group of individuals or organisations can be modelled as games played on networks, where a player's payoff depends not only on their actions but also on those of their neighbours. Inferring the network structure from observed game outcomes (equilibrium actions) is an important problem with numerous potential applications in economics and social sciences. Existing methods mostly require the knowledge of the utility function associated with the game, which is often unrealistic to obtain in real-world scenarios. We adopt a transformer-like architecture which correctly accounts for the symmetries of the problem and learns a mapping from the equilibrium actions to the network structure of the game without explicit knowledge of the utility function. We test our method on three different types of network games using both synthetic and real-world data, and demonstrate its effectiveness in network structure inference and superior performance over existing methods.

Yan Leng, Thibaut Mastrolia, Hao Wang

Time series driven by unobserved latent states frequently exhibit abrupt jump discontinuities whose timing and magnitude cannot be predicted from observed history alone. Classical jump-diffusion models offer a principled mathematical framework but assume rigid parametric forms, while recent neural jump models operate on fully observed trajectories without inferring the hidden states that govern the dynamics. We propose \textit{Deep ZakaiJ}, a latent-state model for partially observed jump-diffusion systems that embeds the Zakai nonlinear filtering equation into a neural encoder--decoder architecture. The encoder recursively updates a belief over the latent state via Strang splitting into three interpretable substeps: prior propagation, diffusion innovation, and jump innovation, yielding a differentiable, first-order-accurate approximation of the exact filtering evolution. The decoder is a structured jump-diffusion model explicitly conditioned on the filtered belief, preserving the separation between continuous dynamics and discontinuous shocks. On synthetic, financial, and oceanographic datasets, \textit{Deep ZakaiJ} improves distributional forecasts while remaining competitive in point accuracy, achieving calibrated predictive intervals and recovering interpretable latent structure in synthetic and qualitative case studies.

Huimin Xu, Seungjun Yi, Terence Lim et al.

Thematic analysis (TA) is a widely used qualitative approach for uncovering latent meanings in unstructured text data. TA provides valuable insights in healthcare but is resource-intensive. Large Language Models (LLMs) have been introduced to perform TA, yet their applications in healthcare remain unexplored. Here, we propose TAMA: A Human-AI Collaborative Thematic Analysis framework using Multi-Agent LLMs for clinical interviews. We leverage the scalability and coherence of multi-agent systems through structured conversations between agents and coordinate the expertise of cardiac experts in TA. Using interview transcripts from parents of children with Anomalous Aortic Origin of a Coronary Artery (AAOCA), a rare congenital heart disease, we demonstrate that TAMA outperforms existing LLM-assisted TA approaches, achieving higher thematic hit rate, coverage, and distinctiveness. TAMA demonstrates strong potential for automated TA in clinical settings by leveraging multi-agent LLM systems with human-in-the-loop integration by enhancing quality while significantly reducing manual workload.

Kailai Yang, Yan Leng, Xin Zhang et al.

Cardiovascular diseases are becoming increasingly prevalent in modern society, with a profound impact on global health and well-being. These Cardiovascular disorders are complex and multifactorial, influenced by genetic predispositions, lifestyle choices, and diverse socioeconomic and clinical factors. Information about these interrelated factors is dispersed across multiple types of textual data, including patient narratives, medical records, and scientific literature. Natural language processing (NLP) has emerged as a powerful approach for analysing such unstructured data, enabling healthcare professionals and researchers to gain deeper insights that may transform the diagnosis, treatment, and prevention of cardiac disorders. This review provides a comprehensive overview of NLP research in cardiology from 2014 to 2025. We systematically searched six literature databases for studies describing NLP applications across a range of cardiovascular diseases. After a rigorous screening process, we identified 265 relevant articles. Each study was analysed across multiple dimensions, including NLP paradigms, cardiology-related tasks, disease types, and data sources. Our findings reveal substantial diversity within these dimensions, reflecting the breadth and evolution of NLP research in cardiology. A temporal analysis further highlights methodological trends, showing a progression from rule-based systems to large language models. Finally, we discuss key challenges and future directions, such as developing interpretable LLMs and integrating multimodal data. To the best of our knowledge, this review represents the most comprehensive synthesis of NLP research in cardiology to date.

Philip DiGiacomo, Haoyang Wang, Jinrui Fang et al.

As AI chatbots gain adoption in clinical medicine, developing effective frameworks for complex, emerging diseases presents significant challenges. We developed and evaluated six Retrieval-Augmented Generation (RAG) corpus configurations for Long COVID (LC) clinical question answering, ranging from expert-curated sources to large-scale literature databases. Our evaluation employed an LLM-as-a-judge framework across faithfulness, relevance, and comprehensiveness metrics using LongCOVID-CQ, a novel dataset of expert-generated clinical questions. Our RAG corpus configuration combining clinical guidelines with high-quality systematic reviews consistently outperformed both narrow single-guideline approaches and large-scale literature databases. Our findings suggest that for emerging diseases, retrieval grounded in curated secondary reviews provides an optimal balance between narrow consensus documents and unfiltered primary literature, supporting clinical decision-making while avoiding information overload and oversimplified guidance. We propose Guide-RAG, a chatbot system and accompanying evaluation framework that integrates both curated expert knowledge and comprehensive literature databases to effectively answer LC clinical questions.

Yuanpei Gao, Qi Yan, Yan Leng et al.

While deep learning methods have achieved strong performance in time series prediction, their black-box nature and inability to explicitly model underlying stochastic processes often limit their generalization to non-stationary data, especially in the presence of abrupt changes. In this work, we introduce Neural MJD, a neural network based non-stationary Merton jump diffusion (MJD) model. Our model explicitly formulates forecasting as a stochastic differential equation (SDE) simulation problem, combining a time-inhomogeneous Itô diffusion to capture non-stationary stochastic dynamics with a time-inhomogeneous compound Poisson process to model abrupt jumps. To enable tractable learning, we introduce a likelihood truncation mechanism that caps the number of jumps within small time intervals and provide a theoretical error bound for this approximation. Additionally, we propose an Euler-Maruyama with restart solver, which achieves a provably lower error bound in estimating expected states and reduced variance compared to the standard solver. Experiments on both synthetic and real-world datasets demonstrate that Neural MJD consistently outperforms state-of-the-art deep learning and statistical learning methods.

Trung Nguyen, Yan Leng

Linear representation hypothesis posits that high-level concepts are encoded as linear directions in the representation spaces of LLMs. Park et al. (2024) formalize this notion by unifying multiple interpretations of linear representation, such as 1-dimensional subspace representation and interventions, using a causal inner product. However, their framework relies on single-token counterfactual pairs and cannot handle ambiguous contrasting pairs, limiting its applicability to complex or context-dependent concepts. We introduce a new notion of binary concepts as unit vectors in a canonical representation space, and utilize LLMs' (neural) activation differences along with maximum likelihood estimation (MLE) to compute concept directions (i.e., steering vectors). Our method, Sum of Activation-base Normalized Difference (SAND), formalizes the use of activation differences modeled as samples from a von Mises-Fisher (vMF) distribution, providing a principled approach to derive concept directions. We extend the applicability of Park et al. (2024) by eliminating the dependency on unembedding representations and single-token pairs. Through experiments with LLaMA models across diverse concepts and benchmarks, we demonstrate that our lightweight approach offers greater flexibility, superior performance in activation engineering tasks like monitoring and manipulation.

Binwu Wang, Yan Leng, Guang Wang et al.

This study develops FusionTransNet, a framework designed for Origin-Destination (OD) flow predictions within smart and multimodal urban transportation systems. Urban transportation complexity arises from the spatiotemporal interactions among various traffic modes. Motivated by analyzing multimodal data from Shenzhen, a framework that can dissect complicated spatiotemporal interactions between these modes, from the microscopic local level to the macroscopic city-wide perspective, is essential. The framework contains three core components: the Intra-modal Learning Module, the Inter-modal Learning Module, and the Prediction Decoder. The Intra-modal Learning Module is designed to analyze spatial dependencies within individual transportation modes, facilitating a granular understanding of single-mode spatiotemporal dynamics. The Inter-modal Learning Module extends this analysis, integrating data across different modes to uncover cross-modal interdependencies, by breaking down the interactions at both local and global scales. Finally, the Prediction Decoder synthesizes insights from the preceding modules to generate accurate OD flow predictions, translating complex multimodal interactions into forecasts. Empirical evaluations conducted in metropolitan contexts, including Shenzhen and New York, demonstrate FusionTransNet's superior predictive accuracy compared to existing state-of-the-art methods. The implication of this study extends beyond urban transportation, as the method for transferring information across different spatiotemporal graphs at both local and global scales can be instrumental in other spatial systems, such as supply chain logistics and epidemics spreading.

Yan Leng, Yuan Yuan

As LLMs increasingly take on roles in human-AI interactions and autonomous AI systems, understanding their social behavior becomes important for informed use and continuous improvement. However, their behaviors in social interactions with humans and other agents, as well as the mechanisms shaping their responses, remain underexplored. To address this gap, we introduce a novel probabilistic framework, State-Understanding-Value-Action (SUVA), to systematically analyze LLM responses in social contexts based on their textual outputs (i.e., utterances). Using canonical behavioral economics games and social preference concepts relatable to LLM users, SUVA assesses LLMs' social behavior through both their final decisions and the response generation processes leading to those decisions. Our analysis of eight LLMs -- including two GPT, four LLaMA, and two Mistral models -- suggests that most models do not generate decisions aligned solely with self-interest; instead, they often produce responses that reflect social welfare considerations and display patterns consistent with direct and indirect reciprocity. Additionally, higher-capacity models more frequently display group identity effects. The SUVA framework also provides explainable tools -- including tree-based visualizations and probabilistic dependency analysis -- to elucidate how factors in LLMs' utterance-based reasoning influence their decisions. We demonstrate that utterance-based reasoning reliably predicts LLMs' final actions; references to altruism, fairness, and cooperation in the reasoning increase the likelihood of prosocial actions, while mentions of self-interest and competition reduce them. Overall, our framework enables practitioners to assess LLMs for applications involving social interactions, and provides researchers with a structured method to interpret how LLM behavior arises from utterance-based reasoning.

Yan Leng, Tara Sowrirajan, Alex Pentland

Decision-making on networks can be explained by both homophily and social influence. While homophily drives the formation of communities with similar characteristics, social influence occurs both within and between communities. Social influence can be reasoned through role theory, which indicates that the influences among individuals depend on their roles and the behavior of interest. To operationalize these social science theories, we empirically identify the homophilous communities and use the community structures to capture the "roles", which affect the particular decision-making processes. We propose a generative model named Stochastic Block Influence Model and jointly analyze both the network formation and the behavioral influence within and between different empirically-identified communities. To evaluate the performance and demonstrate the interpretability of our method, we study the adoption decisions of microfinance in an Indian village. We show that although individuals tend to form links within communities, there are strong positive and negative social influences between communities, supporting the weak tie theory. Moreover, we find that communities with shared characteristics are associated with positive influence. In contrast, the communities with a lack of overlap are associated with negative influence. Our framework facilitates the quantification of the influences underlying decision communities and is thus a useful tool for driving information diffusion, viral marketing, and technology adoptions.

Yan Leng, Xiaowen Dong, Junfeng Wu et al.

Individuals, or organizations, cooperate with or compete against one another in a wide range of practical situations. Such strategic interactions are often modeled as games played on networks, where an individual's payoff depends not only on her action but also on that of her neighbors. The current literature has largely focused on analyzing the characteristics of network games in the scenario where the structure of the network, which is represented by a graph, is known beforehand. It is often the case, however, that the actions of the players are readily observable while the underlying interaction network remains hidden. In this paper, we propose two novel frameworks for learning, from the observations on individual actions, network games with linear-quadratic payoffs, and in particular, the structure of the interaction network. Our frameworks are based on the Nash equilibrium of such games and involve solving a joint optimization problem for the graph structure and the individual marginal benefits. Both synthetic and real-world experiments demonstrate the effectiveness of the proposed frameworks, which have theoretical as well as practical implications for understanding strategic interactions in a network environment.

Dhaval Adjodah, Dan Calacci, Yan Leng et al.

We draw upon a previously largely untapped literature on human collective intelligence as a source of inspiration for improving deep learning. Implicit in many algorithms that attempt to solve Deep Reinforcement Learning (DRL) tasks is the network of processors along which parameter values are shared. So far, existing approaches have implicitly utilized fully-connected networks, in which all processors are connected. However, the scientific literature on human collective intelligence suggests that complete networks may not always be the most effective information network structures for distributed search through complex spaces. Here we show that alternative topologies can improve deep neural network training: we find that sparser networks learn higher rewards faster, leading to learning improvements at lower communication costs.