Y. F. Yang

Qiao Jin, Zifeng Wang, Charalampos S. Floudas et al. · tsinghua

Patient recruitment is challenging for clinical trials. We introduce TrialGPT, an end-to-end framework for zero-shot patient-to-trial matching with large language models. TrialGPT comprises three modules: it first performs large-scale filtering to retrieve candidate trials (TrialGPT-Retrieval); then predicts criterion-level patient eligibility (TrialGPT-Matching); and finally generates trial-level scores (TrialGPT-Ranking). We evaluate TrialGPT on three cohorts of 183 synthetic patients with over 75,000 trial annotations. TrialGPT-Retrieval can recall over 90% of relevant trials using less than 6% of the initial collection. Manual evaluations on 1,015 patient-criterion pairs show that TrialGPT-Matching achieves an accuracy of 87.3% with faithful explanations, close to the expert performance. The TrialGPT-Ranking scores are highly correlated with human judgments and outperform the best-competing models by 43.8% in ranking and excluding trials. Furthermore, our user study reveals that TrialGPT can reduce the screening time by 42.6% in patient recruitment. Overall, these results have demonstrated promising opportunities for patient-to-trial matching with TrialGPT.

Qiao Jin, Yifan Yang, Qingyu Chen et al. · tsinghua

While large language models (LLMs) have been successfully applied to various tasks, they still face challenges with hallucinations. Augmenting LLMs with domain-specific tools such as database utilities can facilitate easier and more precise access to specialized knowledge. In this paper, we present GeneGPT, a novel method for teaching LLMs to use the Web APIs of the National Center for Biotechnology Information (NCBI) for answering genomics questions. Specifically, we prompt Codex to solve the GeneTuring tests with NCBI Web APIs by in-context learning and an augmented decoding algorithm that can detect and execute API calls. Experimental results show that GeneGPT achieves state-of-the-art performance on eight tasks in the GeneTuring benchmark with an average score of 0.83, largely surpassing retrieval-augmented LLMs such as the new Bing (0.44), biomedical LLMs such as BioMedLM (0.08) and BioGPT (0.04), as well as GPT-3 (0.16) and ChatGPT (0.12). Our further analyses suggest that: (1) API demonstrations have good cross-task generalizability and are more useful than documentations for in-context learning; (2) GeneGPT can generalize to longer chains of API calls and answer multi-hop questions in GeneHop, a novel dataset introduced in this work; (3) Different types of errors are enriched in different tasks, providing valuable insights for future improvements.

Yasheng Sun, Yifan Yang, Houwen Peng et al.

While language-guided image manipulation has made remarkable progress, the challenge of how to instruct the manipulation process faithfully reflecting human intentions persists. An accurate and comprehensive description of a manipulation task using natural language is laborious and sometimes even impossible, primarily due to the inherent uncertainty and ambiguity present in linguistic expressions. Is it feasible to accomplish image manipulation without resorting to external cross-modal language information? If this possibility exists, the inherent modality gap would be effortlessly eliminated. In this paper, we propose a novel manipulation methodology, dubbed ImageBrush, that learns visual instructions for more accurate image editing. Our key idea is to employ a pair of transformation images as visual instructions, which not only precisely captures human intention but also facilitates accessibility in real-world scenarios. Capturing visual instructions is particularly challenging because it involves extracting the underlying intentions solely from visual demonstrations and then applying this operation to a new image. To address this challenge, we formulate visual instruction learning as a diffusion-based inpainting problem, where the contextual information is fully exploited through an iterative process of generation. A visual prompting encoder is carefully devised to enhance the model's capacity in uncovering human intent behind the visual instructions. Extensive experiments show that our method generates engaging manipulation results conforming to the transformations entailed in demonstrations. Moreover, our model exhibits robust generalization capabilities on various downstream tasks such as pose transfer, image translation and video inpainting.

Hong Zhang, Yixuan Lyu, Qian Yu et al.

In the domain of Camouflaged Object Segmentation (COS), despite continuous improvements in segmentation performance, the underlying mechanisms of effective camouflage remain poorly understood, akin to a black box. To address this gap, we present the first comprehensive study to examine the impact of camouflage attributes on the effectiveness of camouflage patterns, offering a quantitative framework for the evaluation of camouflage designs. To support this analysis, we have compiled the first dataset comprising descriptions of camouflaged objects and their attribute contributions, termed COD-Text And X-attributions (COD-TAX). Moreover, drawing inspiration from the hierarchical process by which humans process information: from high-level textual descriptions of overarching scenarios, through mid-level summaries of local areas, to low-level pixel data for detailed analysis. We have developed a robust framework that combines textual and visual information for the task of COS, named Attribution CUe Modeling with Eye-fixation Network (ACUMEN). ACUMEN demonstrates superior performance, outperforming nine leading methods across three widely-used datasets. We conclude by highlighting key insights derived from the attributes identified in our study. Code: https://github.com/lyu-yx/ACUMEN.

Xiaoyu Liu, Jiaxin Yuan, Bang An et al.

Representation learning assumes that real-world data is generated by a few semantically meaningful generative factors (i.e., sources of variation) and aims to discover them in the latent space. These factors are expected to be causally disentangled, meaning that distinct factors are encoded into separate latent variables, and changes in one factor will not affect the values of the others. Compared to statistical independence, causal disentanglement allows more controllable data generation, improved robustness, and better generalization. However, most existing work assumes unconfoundedness in the discovery process, that there are no common causes to the generative factors and thus obtain only statistical independence. In this paper, we recognize the importance of modeling confounders in discovering causal generative factors. Unfortunately, such factors are not identifiable without proper inductive bias. We fill the gap by introducing a framework entitled Confounded-Disentanglement (C-Disentanglement), the first framework that explicitly introduces the inductive bias of confounder via labels from domain expertise. In addition, we accordingly propose an approach to sufficiently identify the causally disentangled factors under any inductive bias of the confounder. We conduct extensive experiments on both synthetic and real-world datasets. Our method demonstrates competitive results compared to various SOTA baselines in obtaining causally disentangled features and downstream tasks under domain shifts.

Zhaoyuan He, Yifan Yang, Shuozhe Li et al.

Cloud gaming is a multi-billion dollar industry. A client in cloud gaming sends its movement to the game server on the Internet, which renders and transmits the resulting video back. In order to provide a good gaming experience, a latency below 80 ms is required. This means that video rendering, encoding, transmission, decoding, and display have to finish within that time frame, which is especially challenging to achieve due to server overload, network congestion, and losses. In this paper, we propose a new method for recovering lost or corrupted video frames in cloud gaming. Unlike traditional video frame recovery, our approach uses game states to significantly enhance recovery accuracy and utilizes partially decoded frames to recover lost portions. We develop a holistic system that consists of (i) efficiently extracting game states, (ii) modifying H.264 video decoder to generate a mask to indicate which portions of video frames need recovery, and (iii) designing a novel neural network to recover either complete or partial video frames. Our approach is extensively evaluated using iPhone 12 and laptop implementations, and we demonstrate the utility of game states in the game video recovery and the effectiveness of our overall design.

Bang Zhang, Ruotian Ma, Qingxuan Jiang et al.

Assessing how well a large language model (LLM) understands human, rather than merely text, remains an open challenge. To bridge the gap, we introduce Sentient Agent as a Judge (SAGE), an automated evaluation framework that measures an LLM's higher-order social cognition. SAGE instantiates a Sentient Agent that simulates human-like emotional changes and inner thoughts during interaction, providing a more realistic evaluation of the tested model in multi-turn conversations. At every turn, the agent reasons about (i) how its emotion changes, (ii) how it feels, and (iii) how it should reply, yielding a numerical emotion trajectory and interpretable inner thoughts. Experiments on 100 supportive-dialogue scenarios show that the final Sentient emotion score correlates strongly with Barrett-Lennard Relationship Inventory (BLRI) ratings and utterance-level empathy metrics, validating psychological fidelity. We also build a public Sentient Leaderboard covering 18 commercial and open-source models that uncovers substantial gaps (up to 4x) between frontier systems (GPT-4o-Latest, Gemini2.5-Pro) and earlier baselines, gaps not reflected in conventional leaderboards (e.g., Arena). SAGE thus provides a principled, scalable and interpretable tool for tracking progress toward genuinely empathetic and socially adept language agents.

Yifan Yang, Peili Song, Enfan Lan et al.

Category-level object pose estimation, which predicts the pose of objects within a known category without prior knowledge of individual instances, is essential in applications like warehouse automation and manufacturing. Existing methods relying on RGB images or point cloud data often struggle with object occlusion and generalization across different instances and categories. This paper proposes a multimodal-based keypoint learning framework (MK-Pose) that integrates RGB images, point clouds, and category-level textual descriptions. The model uses a self-supervised keypoint detection module enhanced with attention-based query generation, soft heatmap matching and graph-based relational modeling. Additionally, a graph-enhanced feature fusion module is designed to integrate local geometric information and global context. MK-Pose is evaluated on CAMERA25 and REAL275 dataset, and is further tested for cross-dataset capability on HouseCat6D dataset. The results demonstrate that MK-Pose outperforms existing state-of-the-art methods in both IoU and average precision without shape priors. Codes will be released at \href{https://github.com/yangyifanYYF/MK-Pose}{https://github.com/yangyifanYYF/MK-Pose}.

Chunyu Wei, Wenji Hu, Xingjia Hao et al.

Large Language Models (LLMs) face significant limitations when applied to large-scale graphs, struggling with context constraints and inflexible reasoning. We present GraphChain, a framework that enables LLMs to analyze complex graphs through dynamic sequences of specialized tools, mimicking human exploratory intelligence. Our approach introduces two key innovations: (1) Progressive Graph Distillation, a reinforcement learning mechanism that generates optimized tool sequences balancing task relevance with information compression, and (2) Structure-aware Test-Time Adaptation, which efficiently tailors tool selection strategies to diverse graph topologies using spectral properties and lightweight adapters without costly retraining. Experiments show GraphChain significantly outperforms prior methods, enabling scalable and adaptive LLM-driven graph analysis.

Nguyen Gia Hien Vu, Yifan Tang, Rey Lim et al.

Tabular Prior-Data Fitted Network (TabPFN) is a foundation model designed for small to medium-sized tabular data, which has attracted much attention recently. This paper investigates the application of TabPFN in Combinatorial Optimization (CO) problems. The aim is to lessen challenges in time and data-intensive training requirements often observed in using traditional methods including exact and heuristic algorithms, Machine Learning (ML)-based models, to solve CO problems. Proposing possibly the first ever application of TabPFN for such a purpose, we adapt and fine-tune the TabPFN model to solve the Travelling Salesman Problem (TSP), one of the most well-known CO problems. Specifically, we adopt the node-based approach and the node-predicting adaptation strategy to construct the entire TSP route. Our evaluation with varying instance sizes confirms that TabPFN requires minimal training, adapts to TSP using a single sample, performs better generalization across varying TSP instance sizes, and reduces performance degradation. Furthermore, the training process with adaptation and fine-tuning is completed within minutes. The methodology leads to strong solution quality even without post-processing and achieves performance comparable to other models with post-processing refinement. Our findings suggest that the TabPFN model is a promising approach to solve structured and CO problems efficiently under training resource constraints and rapid deployment requirements.

Tonghui Ren, Yuankai Fan, Zhenying He et al.

Large Language Model (LLM) techniques play an increasingly important role in Natural Language to SQL (NL2SQL) translation. LLMs trained by extensive corpora have strong natural language understanding and basic SQL generation abilities without additional tuning specific to NL2SQL tasks. Existing LLMs-based NL2SQL approaches try to improve the translation by enhancing the LLMs with an emphasis on user intention understanding. However, LLMs sometimes fail to generate appropriate SQL due to their lack of knowledge in organizing complex logical operator composition. A promising method is to input the LLMs with demonstrations, which include known NL2SQL translations from various databases. LLMs can learn to organize operator compositions from the input demonstrations for the given task. In this paper, we propose PURPLE (Pre-trained models Utilized to Retrieve Prompts for Logical Enhancement), which improves accuracy by retrieving demonstrations containing the requisite logical operator composition for the NL2SQL task on hand, thereby guiding LLMs to produce better SQL translation. PURPLE achieves a new state-of-the-art performance of 80.5% exact-set match accuracy and 87.8% execution match accuracy on the validation set of the popular NL2SQL benchmark Spider. PURPLE maintains high accuracy across diverse benchmarks, budgetary constraints, and various LLMs, showing robustness and cost-effectiveness.

Xiaoshuai Hao, Yunfeng Diao, Mengchuan Wei et al.

Map construction task plays a vital role in providing precise and comprehensive static environmental information essential for autonomous driving systems. Primary sensors include cameras and LiDAR, with configurations varying between camera-only, LiDAR-only, or camera-LiDAR fusion, based on cost-performance considerations. While fusion-based methods typically perform best, existing approaches often neglect modality interaction and rely on simple fusion strategies, which suffer from the problems of misalignment and information loss. To address these issues, we propose MapFusion, a novel multi-modal Bird's-Eye View (BEV) feature fusion method for map construction. Specifically, to solve the semantic misalignment problem between camera and LiDAR BEV features, we introduce the Cross-modal Interaction Transform (CIT) module, enabling interaction between two BEV feature spaces and enhancing feature representation through a self-attention mechanism. Additionally, we propose an effective Dual Dynamic Fusion (DDF) module to adaptively select valuable information from different modalities, which can take full advantage of the inherent information between different modalities. Moreover, MapFusion is designed to be simple and plug-and-play, easily integrated into existing pipelines. We evaluate MapFusion on two map construction tasks, including High-definition (HD) map and BEV map segmentation, to show its versatility and effectiveness. Compared with the state-of-the-art methods, MapFusion achieves 3.6% and 6.2% absolute improvements on the HD map construction and BEV map segmentation tasks on the nuScenes dataset, respectively, demonstrating the superiority of our approach.

Peisong Wang, Ruotian Ma, Bang Zhang et al.

Large language models (LLMs) excel at logical and algorithmic reasoning, yet their emotional intelligence (EQ) still lags far behind their cognitive prowess. While reinforcement learning from verifiable rewards (RLVR) has advanced in other domains, its application to dialogue-especially for emotional intelligence-remains underexplored. In this work, we introduce RLVER, the first end-to-end reinforcement learning framework that leverages verifiable emotion rewards from simulated users to cultivate higher-order empathetic abilities in LLMs. Within this framework, self-consistent affective simulated users engage in dialogue rollouts and produce deterministic emotion scores during conversations, serving as reward signals to guide the LLM's learning. Fine-tuning publicly available Qwen2.5-7B-Instruct model with PPO boosts its Sentient-Benchmark score from 13.3 to 79.2 while largely preserving mathematical and coding competence. Extensive experiments reveal that: (i) RLVER consistently improves multiple dialogue capabilities; (ii) Thinking and non-thinking models show distinct trends--thinking models excel in empathy and insight, while non-thinking models favor action; (iii) GRPO often yields stable gains, while PPO can push certain capabilities to a higher ceiling; (iv) More challenging environments are not always better-moderate ones can yield stronger outcomes. Our results show that RLVER is a practical route toward emotionally intelligent and broadly capable language agents.

Jiawei Jiang, Yifan Yang, Jingyuan Wang et al.

The electronic map plays a crucial role in geographic information systems, serving various urban managerial scenarios and daily life services. Developing effective Map Entity Representation Learning (MERL) methods is crucial to extracting embedding information from electronic maps and converting map entities into representation vectors for downstream applications. However, existing MERL methods typically focus on one specific category of map entities, such as POIs, road segments, or land parcels, which is insufficient for real-world diverse map-based applications and might lose latent structural and semantic information interacting between entities of different types. Moreover, using representations generated by separate models for different map entities can introduce inconsistencies. Motivated by this, we propose a novel method named HOME-GCL for learning representations of multiple categories of map entities. Our approach utilizes a heterogeneous map entity graph (HOME graph) that integrates both road segments and land parcels into a unified framework. A HOME encoder with parcel-segment joint feature encoding and heterogeneous graph transformer is then deliberately designed to convert segments and parcels into representation vectors. Moreover, we introduce two types of contrastive learning tasks, namely intra-entity and inter-entity tasks, to train the encoder in a self-supervised manner. Extensive experiments on three large-scale datasets covering road segment-based, land parcel-based, and trajectory-based tasks demonstrate the superiority of our approach. To the best of our knowledge, HOME-GCL is the first attempt to jointly learn representations for road segments and land parcels using a unified model.

Yifan Yang, Peiyao Xiao, Kaiyi Ji

In this paper, we revisit the bilevel optimization problem, in which the upper-level objective function is generally nonconvex and the lower-level objective function is strongly convex. Although this type of problem has been studied extensively, it still remains an open question how to achieve an ${O}(ε^{-1.5})$ sample complexity in Hessian/Jacobian-free stochastic bilevel optimization without any second-order derivative computation. To fill this gap, we propose a novel Hessian/Jacobian-free bilevel optimizer named FdeHBO, which features a simple fully single-loop structure, a projection-aided finite-difference Hessian/Jacobian-vector approximation, and momentum-based updates. Theoretically, we show that FdeHBO requires ${O}(ε^{-1.5})$ iterations (each using ${O}(1)$ samples and only first-order gradient information) to find an $ε$-accurate stationary point. As far as we know, this is the first Hessian/Jacobian-free method with an ${O}(ε^{-1.5})$ sample complexity for nonconvex-strongly-convex stochastic bilevel optimization.

Anton Obukhov, Matteo Poggi, Fabio Tosi et al.

This paper presents the results of the fourth edition of the Monocular Depth Estimation Challenge (MDEC), which focuses on zero-shot generalization to the SYNS-Patches benchmark, a dataset featuring challenging environments in both natural and indoor settings. In this edition, we revised the evaluation protocol to use least-squares alignment with two degrees of freedom to support disparity and affine-invariant predictions. We also revised the baselines and included popular off-the-shelf methods: Depth Anything v2 and Marigold. The challenge received a total of 24 submissions that outperformed the baselines on the test set; 10 of these included a report describing their approach, with most leading methods relying on affine-invariant predictions. The challenge winners improved the 3D F-Score over the previous edition's best result, raising it from 22.58% to 23.05%.

Yifan Yang, Zhen Zhang, Rupak Vignesh Swaminathan et al.

Fine-tuning vision language models (VLMs) has achieved remarkable performance across various downstream tasks; yet, it requires access to model gradients through backpropagation (BP), making them unsuitable for memory-constrained, inference-only edge devices. To address this limitation, previous work has explored various BP-free fine-tuning methods. However, these approaches often rely on high-variance evolutionary strategies (ES) or zeroth-order (ZO) optimization, and often fail to achieve satisfactory performance. In this paper, we propose a hybrid Sharpness-aware Zeroth-order optimization (SharpZO) approach, specifically designed to enhance the performance of ZO VLM fine-tuning via a sharpness-aware warm-up training. SharpZO features a two-stage optimization process: a sharpness-aware ES stage that globally explores and smooths the loss landscape to construct a strong initialization, followed by a fine-grained local search via sparse ZO optimization. The entire optimization relies solely on forward passes. Detailed theoretical analysis and extensive experiments on CLIP models demonstrate that SharpZO significantly improves accuracy and convergence speed, achieving up to 7% average gain over state-of-the-art forward-only methods.

Jiaxu Wan, Hong Zhang, Ziqi He et al.

Point transformers have demonstrated remarkable progress in 3D understanding through expanded receptive fields (RF), but further expanding the RF leads to dilution in group attention and decreases detailed feature extraction capability. Proxy, which serves as abstract representations for simplifying feature maps, enables global RF. However, existing proxy-based approaches face critical limitations: Global proxies incur quadratic complexity for large-scale point clouds and suffer positional ambiguity, while local proxy alternatives struggle with 1) Unreliable sampling from the geometrically diverse point cloud, 2) Inefficient proxy interaction computation, and 3) Imbalanced local-global information fusion; To address these challenges, we propose Sparse Proxy Point Transformer (SP$^{2}$T) -- a local proxy-based dual-stream point transformer with three key innovations: First, for reliable sampling, spatial-wise proxy sampling with vertex-based associations enables robust sampling on geometrically diverse point clouds. Second, for efficient proxy interaction, sparse proxy attention with a table-based relative bias effectively achieves the interaction with efficient map-reduce computation. Third, for local-global information fusion, our dual-stream architecture maintains local-global balance through parallel branches. Comprehensive experiments reveal that SP$^{2}$T sets state-of-the-art results with acceptable latency on indoor and outdoor 3D comprehension benchmarks, demonstrating marked improvement (+3.8% mIoU vs. SPoTr@S3DIS, +22.9% mIoU vs. PointASNL@Sem.KITTI) compared to other proxy-based point cloud methods.

Peili Song, Dezhen Song, Yifan Yang et al.

Low-cost millimeter automotive radar has received more and more attention due to its ability to handle adverse weather and lighting conditions in autonomous driving. However, the lack of quality datasets hinders research and development. We report a new method that is able to simulate 4D millimeter wave radar signals including pitch, yaw, range, and Doppler velocity along with radar signal strength (RSS) using camera image, light detection and ranging (lidar) point cloud, and ego-velocity. The method is based on two new neural networks: 1) DIS-Net, which estimates the spatial distribution and number of radar signals, and 2) RSS-Net, which predicts the RSS of the signal based on appearance and geometric information. We have implemented and tested our method using open datasets from 3 different models of commercial automotive radar. The experimental results show that our method can successfully generate high-fidelity radar signals. Moreover, we have trained a popular object detection neural network with data augmented by our synthesized radar. The network outperforms the counterpart trained only on raw radar data, a promising result to facilitate future radar-based research and development.

Yifan Yang, Xiaoyu Liu, Qiao Jin et al.

Large language models like GPT-3.5-turbo and GPT-4 hold promise for healthcare professionals, but they may inadvertently inherit biases during their training, potentially affecting their utility in medical applications. Despite few attempts in the past, the precise impact and extent of these biases remain uncertain. Through both qualitative and quantitative analyses, we find that these models tend to project higher costs and longer hospitalizations for White populations and exhibit optimistic views in challenging medical scenarios with much higher survival rates. These biases, which mirror real-world healthcare disparities, are evident in the generation of patient backgrounds, the association of specific diseases with certain races, and disparities in treatment recommendations, etc. Our findings underscore the critical need for future research to address and mitigate biases in language models, especially in critical healthcare applications, to ensure fair and accurate outcomes for all patients.

Yifan Yang, Peiyao Xiao, Kaiyi Ji

Federated bilevel optimization (FBO) has shown great potential recently in machine learning and edge computing due to the emerging nested optimization structure in meta-learning, fine-tuning, hyperparameter tuning, etc. However, existing FBO algorithms often involve complicated computations and require multiple sub-loops per iteration, each of which contains a number of communication rounds. In this paper, we propose a simple and flexible FBO framework named SimFBO, which is easy to implement without sub-loops, and includes a generalized server-side aggregation and update for improving communication efficiency. We further propose System-level heterogeneity robust FBO (ShroFBO) as a variant of SimFBO with stronger resilience to heterogeneous local computation. We show that SimFBO and ShroFBO provably achieve a linear convergence speedup with partial client participation and client sampling without replacement, as well as improved sample and communication complexities. Experiments demonstrate the effectiveness of the proposed methods over existing FBO algorithms.

Tianqi Shen, Hong Zhang, Ding Yuan et al.

Vital importance has necessity to be attached to cooperation in multi-agent environments, as a result of which some reinforcement learning algorithms combined with graph neural networks have been proposed to understand the mutual interplay between agents. However, highly complicated and dynamic multi-agent environments require more ingenious graph neural networks, which can comprehensively represent not only the graph topology structure but also evolution process of the structure due to agents emerging, disappearing and moving. To tackle these difficulties, we propose Gumbel Sinkhorn graph attention reinforcement learning, where a graph attention network highly represents the underlying graph topology structure of the multi-agent environment, and can adapt to the dynamic topology structure of graph better with the help of Gumbel Sinkhorn network by learning latent permutations. Empirically, simulation results show how our proposed graph reinforcement learning methodology outperforms existing methods in the PettingZoo multi-agent environment by learning latent permutations.

Jian Tang, Yifan Yang, Sam Carton et al.

This paper studied generating natural languages at particular contexts or situations. We proposed two novel approaches which encode the contexts into a continuous semantic representation and then decode the semantic representation into text sequences with recurrent neural networks. During decoding, the context information are attended through a gating mechanism, addressing the problem of long-range dependency caused by lengthy sequences. We evaluate the effectiveness of the proposed approaches on user review data, in which rich contexts are available and two informative contexts, sentiments and products, are selected for evaluation. Experiments show that the fake reviews generated by our approaches are very natural. Results of fake review detection with human judges show that more than 50\% of the fake reviews are misclassified as the real reviews, and more than 90\% are misclassified by existing state-of-the-art fake review detection algorithm.