Angus G. Forbes

Mengdi Chu, Jiaxin Yang, Angus G. Forbes et al.

Modeling temporal evolution is important to analyzing and reasoning about scientific phenomena, yet most machine learning methods provide deterministic forward predictions that overlook multiple plausible outcomes and rarely support backward reasoning, limiting their usefulness in practical scientific workflows. We present a framework that integrates diffusion-based generative modeling with interactive visual analytics for scientific exploration. We introduce DiffUNet^2, a conditional diffusion model that enables bidirectional, any-to-any generation across time and captures distributions of plausible system evolutions. Built upon the model, our interactive system supports branching timeline exploration, user-guided state editing, and probability-space navigation, enabling scientists to actively explore alternative hypotheses rather than passively observe predictions. We evaluate the model on 5 datasets across different scientific domains to validate its predictive accuracy and probability-space ensemble quality. In collaboration with domain experts, we demonstrate the effectiveness of our approach in supporting practical scientific temporal data analysis workflows. By integrating modeling and visual interaction, our approach enables scientists to interactively explore system dynamics, transforming generative models into tools for hypothesis-driven scientific analysis.

Oskar Elek, Joseph N. Burchett, J. Xavier Prochaska et al.

We present Monte Carlo Physarum Machine: a computational model suitable for reconstructing continuous transport networks from sparse 2D and 3D data. MCPM is a probabilistic generalization of Jones's 2010 agent-based model for simulating the growth of Physarum polycephalum slime mold. We compare MCPM to Jones's work on theoretical grounds, and describe a task-specific variant designed for reconstructing the large-scale distribution of gas and dark matter in the Universe known as the Cosmic web. To analyze the new model, we first explore MCPM's self-patterning behavior, showing a wide range of continuous network-like morphologies -- called "polyphorms" -- that the model produces from geometrically intuitive parameters. Applying MCPM to both simulated and observational cosmological datasets, we then evaluate its ability to produce consistent 3D density maps of the Cosmic web. Finally, we examine other possible tasks where MCPM could be useful, along with several examples of fitting to domain-specific data as proofs of concept.

Nabin Khanal, Chun Meng Yu, Jui-Cheng Chiu et al.

We introduce FathomGPT, an open source system for the interactive investigation of ocean science data via a natural language interface. FathomGPT was developed in close collaboration with marine scientists to enable researchers to explore and analyze the FathomNet image database. FathomGPT provides a custom information retrieval pipeline that leverages OpenAI's large language models to enable: the creation of complex queries to retrieve images, taxonomic information, and scientific measurements; mapping common names and morphological features to scientific names; generating interactive charts on demand; and searching by image or specified patterns within an image. In designing FathomGPT, particular emphasis was placed on enhancing the user's experience by facilitating free-form exploration and optimizing response times. We present an architectural overview and implementation details of FathomGPT, along with a series of ablation studies that demonstrate the effectiveness of our approach to name resolution, fine tuning, and prompt modification. We also present usage scenarios of interactive data exploration sessions and document feedback from ocean scientists and machine learning experts.

Angus G. Forbes, Andrew Burks, Kristine Lee et al.

We introduce the Dynamic Influence Network (DIN), a novel visual analytics technique for representing and analyzing rule-based models of protein-protein interaction networks. Rule-based modeling has proved instrumental in developing biological models that are concise, comprehensible, easily extensible, and that mitigate the combinatorial complexity of multi-state and multi-component biological molecules. Our technique visualizes the dynamics of these rules as they evolve over time. Using the data produced by KaSim, an open source stochastic simulator of rule-based models written in the Kappa language, DINs provide a node-link diagram that represents the influence that each rule has on the other rules. That is, rather than representing individual biological components or types, we instead represent the rules about them (as nodes) and the current influence of these rules (as links). Using our interactive DIN-Viz software tool, researchers are able to query this dynamic network to find meaningful patterns about biological processes, and to identify salient aspects of complex rule-based models. To evaluate the effectiveness of our approach, we investigate a simulation of a circadian clock model that illustrates the oscillatory behavior of the KaiC protein phosphorylation cycle.

Fangfei Lan, Michael Young, Lauren Anderson et al.

We present a state-of-the-art report on visualization in astrophysics. We survey representative papers from both astrophysics and visualization and provide a taxonomy of existing approaches based on data analysis tasks. The approaches are classified based on five categories: data wrangling, data exploration, feature identification, object reconstruction, as well as education and outreach. Our unique contribution is to combine the diverse viewpoints from both astronomers and visualization experts to identify challenges and opportunities for visualization in astrophysics. The main goal is to provide a reference point to bring modern data analysis and visualization techniques to the rich datasets in astrophysics.

Hongwei, Zhou, Oskar Elek et al.

Word embeddings are a popular way to improve downstream performances in contemporary language modeling. However, the underlying geometric structure of the embedding space is not well understood. We present a series of explorations using bio-inspired methodology to traverse and visualize word embeddings, demonstrating evidence of discernible structure. Moreover, our model also produces word similarity rankings that are plausible yet very different from common similarity metrics, mainly cosine similarity and Euclidean distance. We show that our bio-inspired model can be used to investigate how different word embedding techniques result in different semantic outputs, which can emphasize or obscure particular interpretations in textual data.

Oskar Elek, Joseph N. Burchett, J. Xavier Prochaska et al.

This paper introduces Polyphorm, an interactive visualization and model fitting tool that provides a novel approach for investigating cosmological datasets. Through a fast computational simulation method inspired by the behavior of Physarum polycephalum, an unicellular slime mold organism that efficiently forages for nutrients, astrophysicists are able to extrapolate from sparse datasets, such as galaxy maps archived in the Sloan Digital Sky Survey, and then use these extrapolations to inform analyses of a wide range of other data, such as spectroscopic observations captured by the Hubble Space Telescope. Researchers can interactively update the simulation by adjusting model parameters, and then investigate the resulting visual output to form hypotheses about the data. We describe details of Polyphorm's simulation model and its interaction and visualization modalities, and we evaluate Polyphorm through three scientific use cases that demonstrate the effectiveness of our approach.

David Abramov, Jasmine Otto, Mahika Dubey et al.

We introduce RuleVis, a web-based application for defining and editing "correct-by-construction" executable rules that model biochemical functionality, which can be used to simulate the behavior of protein-protein interaction networks and other complex systems. Rule-based models involve emergent effects based on the interactions between rules, which can vary considerably with regard to the scale of a model, requiring the user to inspect and edit individual rules. RuleVis bridges the graph rewriting and systems biology research communities by providing an external visual representation of salient patterns that experts can use to determine the appropriate level of detail for a particular modeling context. We describe the visualization and interaction features available in RuleVisand provide a detailed example demonstrating how RuleVis can be used to reason about intracellular interactions.

Ran Xu, Manu Mathew Thomas, Alex Leow et al.

We introduce TempoCave, a novel visualization application for analyzing dynamic brain networks, or connectomes. TempoCave provides a range of functionality to explore metrics related to the activity patterns and modular affiliations of different regions in the brain. These patterns are calculated by processing raw data retrieved functional magnetic resonance imaging (fMRI) scans, which creates a network of weighted edges between each brain region, where the weight indicates how likely these regions are to activate synchronously. In particular, we support the analysis needs of clinical psychologists, who examine these modular affiliations and weighted edges and their temporal dynamics, utilizing them to understand relationships between neurological disorders and brain activity, which could have a significant impact on the way in which patients are diagnosed and treated. We summarize the core functionality of TempoCave, which supports a range of comparative tasks, and runs both in a desktop mode and in an immersive mode. Furthermore, we present a real-world use case that analyzes pre- and post-treatment connectome datasets from 27 subjects in a clinical study investigating the use of cognitive behavior therapy to treat major depression disorder, indicating that TempoCave can provide new insight into the dynamic behavior of the human brain.

Marco Cavallo, Angus G. Forbes

Despite advances in augmented reality (AR), the process of creating meaningful experiences with this technology is still extremely challenging. Due to different tracking implementations and hardware constraints, developing AR applications either requires low-level programming skills, or is done through specific authoring tools that largely sacrifice the possibility of customizing the AR experience. Existing development workflows also do not support previewing or simulating the AR experience, requiring a lengthy process of trial and error by which content creators deploy and physically test applications in each iteration. To mitigate these limitations, we propose CAVE-AR, a novel virtual reality system for authoring, simulating and debugging custom AR experiences. Available both as a standalone or a plug-in tool, CAVE-AR is based on the concept of representing in the same global reference system both in AR content and tracking information, mixing geographical information, architectural features, and sensor data to simulate the context of an AR experience. Thanks to its novel abstraction of existing tracking technologies, CAVE-AR operates independently of users' devices, and integrates with existing programming tools to provide maximum flexibility. Our VR application provides designers with ways to create and modify an AR application, even while others are in the midst of using it. CAVE-AR further allows the designer to track how users are behaving, preview what they are currently seeing, and interact with them through several different channels. To illustrate our proposed development workflow and demonstrate the advantages of our authoring system, we introduce two CAVEAR use cases in which an augmented reality application is created and tested. We compare the CAVE-AR workflow to traditional development methods and demonstrate the importance of simulation and live application debugging.

Angus G. Forbes, Kristine Lee, Gus Hahn-Powell et al.

This paper introduces a new web-based software tool for annotating text, Text Annotation Graphs, or TAG. It provides functionality for representing complex relationships between words and word phrases that are not available in other software tools, including the ability to define and visualize relationships between the relationships themselves (semantic hypergraphs). Additionally, we include an approach to representing text annotations in which annotation subgraphs, or semantic summaries, are used to show relationships outside of the sequential context of the text itself. Users can use these subgraphs to quickly find similar structures within the current document or external annotated documents. Initially, TAG was developed to support information extraction tasks on a large database of biomedical articles. However, our software is flexible enough to support a wide range of annotation tasks for any domain. Examples are provided that showcase TAG's capabilities on morphological parsing and event extraction tasks. The TAG software is available at: https://github.com/ CreativeCodingLab/TextAnnotationGraphs.

Johnson J. G. Keiriz, Liang Zhan, Morris Chukhman et al.

Visually comparing brain networks, or connectomes, is an essential task in the field of neuroscience. Especially relevant to the field of clinical neuroscience, group studies that examine differences between populations or changes over time within a population enable neuroscientists to reason about effective diagnoses and treatments for a range of neuropsychiatric disorders. In this paper, we specifically explore how visual analytics tools can be used to facilitate various clinical neuroscience tasks, in which observation and analysis of meaningful patterns in the connectome can support patient diagnosis and treatment. We conduct a survey of visualization tasks that enable clinical neuroscience activities, and further explore how existing connectome visualization tools support or fail to support these tasks. Based on our investigation of these tasks, we introduce a novel visualization tool, NeuroCave, to support group studies analyses. We discuss how our design decisions (the use of immersive visualization, the use of hierarchical clustering and dimensionality reduction techniques, and the choice of visual encodings) are motivated by these tasks. We evaluate NeuroCave through two use cases that illustrate the utility of interactive connectome visualization in clinical neuroscience contexts. In the first use case, we study sex differences using functional connectomes and discover hidden connectome patterns associated with well-known cognitive differences in spatial and verbal abilities. In the second use case, we show how the utility of visualizing the brain in different topological space coupled with clustering information can reveal the brain's intrinsic structure.