Ryota Maeda

Hirofumi Tsuruta, Hiroyuki Yamazaki, Ryota Maeda et al.

Antibodies have become an important class of therapeutic agents to treat human diseases. To accelerate therapeutic antibody discovery, computational methods, especially machine learning, have attracted considerable interest for predicting specific interactions between antibody candidates and target antigens such as viruses and bacteria. However, the publicly available datasets in existing works have notable limitations, such as small sizes and the lack of non-binding samples and exact amino acid sequences. To overcome these limitations, we have developed AVIDa-hIL6, a large-scale dataset for predicting antigen-antibody interactions in the variable domain of heavy chain of heavy chain antibodies (VHHs), produced from an alpaca immunized with the human interleukin-6 (IL-6) protein, as antigens. By leveraging the simple structure of VHHs, which facilitates identification of full-length amino acid sequences by DNA sequencing technology, AVIDa-hIL6 contains 573,891 antigen-VHH pairs with amino acid sequences. All the antigen-VHH pairs have reliable labels for binding or non-binding, as generated by a novel labeling method. Furthermore, via introduction of artificial mutations, AVIDa-hIL6 contains 30 different mutants in addition to wild-type IL-6 protein. This characteristic provides opportunities to develop machine learning models for predicting changes in antibody binding by antigen mutations. We report experimental benchmark results on AVIDa-hIL6 by using machine learning models. The results indicate that the existing models have potential, but further research is needed to generalize them to predict effective antibodies against unknown mutants. The dataset is available at https://avida-hil6.cognanous.com.

Suhyun Shin, Yunseong Moon, Ryota Maeda et al.

Hyperspectral 3D imaging enables the capture of dense spectral information and scene geometry but has traditionally been confined to narrow spectral windows, typically the visible range. In this work, we introduce a broadband hyperspectral 3D imaging (BH3D) method to extend this capability across the full visible-near-infrared and short-wavelength infrared (SWIR) spectrum (450-1500 nm). This broad coverage is critical as it captures complementary physical cues: visible wavelengths reveal surface appearance, while SWIR bands provide insight into subsurface properties and material composition. However, realizing BH3D is challenging due to fundamental sensor constraints between visible-spectrum silicon and SWIR-spectrum InGaAs sensors, which necessitate complex multi-spectrograph designs. Here we propose a single-spectrograph BH3D system, using a stereo setup comprising visible and SWIR cameras, that reconstructs dense broadband hyperspectral reflectance together with accurate 3D geometry. Our key idea is to extend dispersed structured light to the broadband regime using a single spectrograph. We model the image formation of broadband dispersed structured light, and estimate hyperspectral reflectance and depth. We validate our approach on diverse real-world scenes, demonstrating accurate reconstruction with a mean spectral angle mapper of 0.13 rad, root mean square error of 0.03, and mean depth error of 4.5 mm. We further demonstrate identifying metameric materials, performing imaging through opaque layers, uncovering hidden features on banknotes, and revealing blood vessels.

Ryota Maeda, Naoki Arikawa, Yutaka No et al.

Material classification is a fundamental problem in computer vision and plays a crucial role in scene understanding. Previous studies have explored various material recognition methods based on reflection properties such as color, texture, specularity, and scattering. Among these cues, polarization is particularly valuable because it provides rich material information and enables recognition even at distances where capturing high-resolution texture is impractical. However, measuring polarimetric reflectance properties typically requires multiple modulations of the polarization state of the incident light, making the process time-consuming and often unnecessary for certain recognition tasks. While material classification can be achieved using only a subset of polarimetric measurements, the optimal configuration of measurement angles remains unclear. In this study, we propose an end-to-end optimization framework that jointly learns a material classifier and determines the optimal combinations of rotation angles for polarization elements that control both the incident and reflected light states. Using our Mueller-matrix material dataset, we demonstrate that our method achieves high-accuracy material classification even with a limited number of measurements.

Ryota Maeda, Shinsaku Hiura

Polarization is well known for its ability to decompose diffuse and specular reflections. However, the existing decomposition methods only focus on direct reflection and overlook multiple reflections, especially specular inter-reflection. In this paper, we propose a novel decomposition method for handling specular inter-reflection of metal objects by using a unique polarimetric feature: the rotation direction of linear polarization. This rotation direction serves as a discriminative factor between direct and inter-reflection on specular surfaces. To decompose the reflectance components, we actively rotate the linear polarization of incident light and analyze the rotation direction of the reflected light. We evaluate our method using both synthetic and real data, demonstrating its effectiveness in decomposing specular inter-reflections of metal objects. Furthermore, we demonstrate that our method can be combined with other decomposition methods for a detailed analysis of light transport. As a practical application, we show its effectiveness in improving the accuracy of 3D measurement against strong specular inter-reflection.

Ryota Maeda, Yunseong Moon, Seung-Hwan Baek

Light-matter interactions modify both the intensity and polarization state of light. Changes in polarization, represented by a Mueller matrix, encode detailed scene information. Existing optical ellipsometers capture Mueller-matrix images; however, they are often limited to capturing static scenes due to long acquisition times. Here, we introduce Event Ellipsometer, a method for acquiring a Mueller-matrix video for dynamic scenes. Our imaging system employs fast-rotating quarter-wave plates (QWPs) in front of a light source and an event camera that asynchronously captures intensity changes induced by the rotating QWPs. We develop an ellipsometric-event image formation model, a calibration method, and an ellipsometric-event reconstruction method. We experimentally demonstrate that Event Ellipsometer enables Mueller-matrix video imaging at 30fps, extending ellipsometry to dynamic scenes.

Suhyun Shin, Seungwoo Yoon, Ryota Maeda et al.

Hyperspectral 3D imaging captures both depth maps and hyperspectral images, enabling comprehensive geometric and material analysis. Recent methods achieve high spectral and depth accuracy; however, they require long acquisition times often over several minutes or rely on large, expensive systems, restricting their use to static scenes. We present Dense Dispersed Structured Light (DDSL), an accurate hyperspectral 3D imaging method for dynamic scenes that utilizes stereo RGB cameras and an RGB projector equipped with an affordable diffraction grating film. We design spectrally multiplexed DDSL patterns that significantly reduce the number of required projector patterns, thereby accelerating acquisition speed. Additionally, we formulate an image formation model and a reconstruction method to estimate a hyperspectral image and depth map from captured stereo images. As the first practical and accurate hyperspectral 3D imaging method for dynamic scenes, we experimentally demonstrate that DDSL achieves a spectral resolution of 15.5 nm full width at half maximum (FWHM), a depth error of 4 mm, and a frame rate of 6.6 fps.