Yan Liang

Yifan Zhou, Yan Shing Liang, Yew Kee Wong et al.

The Research & Development (R&D) phase of drug development is a lengthy and costly process. To revolutionize this process, we introduce our new concept QMLS to shorten the whole R&D phase to three to six months and decrease the cost to merely fifty to eighty thousand USD. For Hit Generation, Machine Learning Molecule Generation (MLMG) generates possible hits according to the molecular structure of the target protein while the Quantum Simulation (QS) filters molecules from the primary essay based on the reaction and binding effectiveness with the target protein. Then, For Lead Optimization, the resultant molecules generated and filtered from MLMG and QS are compared, and molecules that appear as a result of both processes will be made into dozens of molecular variations through Machine Learning Molecule Variation (MLMV), while others will only be made into a few variations. Lastly, all optimized molecules would undergo multiple rounds of QS filtering with a high standard for reaction effectiveness and safety, creating a few dozen pre-clinical-trail-ready drugs. This paper is based on our first paper, where we pitched the concept of machine learning combined with quantum simulations. In this paper we will go over the detailed design and framework of QMLS, including MLMG, MLMV, and QS.

Yifan Zhou, Yan Shing Liang

Quantum Image Processing (QIP) is a field that aims to utilize the benefits of quantum computing for manipulating and analyzing images. However, QIP faces two challenges: the limitation of qubits and the presence of noise in a quantum machine. In this research, we propose a novel approach to address the issue of noise in QIP. By training and employing a machine learning model that identifies and corrects the noise in quantum-processed images, we can compensate for the noisiness caused by the machine and retrieve a processing result similar to that performed by a classical computer with higher efficiency. The model is trained by learning a dataset consisting of both existing processed images and quantum-processed images from open-access datasets. This model will be capable of providing us with the confidence level for each pixel and its potential original value. To assess the model's accuracy in compensating for loss and decoherence in QIP, we evaluate it using three metrics: Peak Signal to Noise Ratio (PSNR), Structural Similarity Index (SSIM), and Mean Opinion Score (MOS). Additionally, we discuss the applicability of our model across domains well as its cost effectiveness compared to alternative methods.

Lianghu Guo, Tianli Tao, Xinyi Cai et al.

Early infancy is a rapid and dynamic neurodevelopmental period for behavior and neurocognition. Longitudinal magnetic resonance imaging (MRI) is an effective tool to investigate such a crucial stage by capturing the developmental trajectories of the brain structures. However, longitudinal MRI acquisition always meets a serious data-missing problem due to participant dropout and failed scans, making longitudinal infant brain atlas construction and developmental trajectory delineation quite challenging. Thanks to the development of an AI-based generative model, neuroimage completion has become a powerful technique to retain as much available data as possible. However, current image completion methods usually suffer from inconsistency within each individual subject in the time dimension, compromising the overall quality. To solve this problem, our paper proposed a two-stage cascaded diffusion model, Cas-DiffCom, for dense and longitudinal 3D infant brain MRI completion and super-resolution. We applied our proposed method to the Baby Connectome Project (BCP) dataset. The experiment results validate that Cas-DiffCom achieves both individual consistency and high fidelity in longitudinal infant brain image completion. We further applied the generated infant brain images to two downstream tasks, brain tissue segmentation and developmental trajectory delineation, to declare its task-oriented potential in the neuroscience field.

Chaoxiong Ma, Yan Liang, Xinyu Yang et al.

The theory of evidence reasoning has been applied to collective decision-making in recent years. However, existing distributed evidence fusion methods lead to participants' preference leakage and fusion failures as they directly exchange raw evidence and do not assess evidence credibility like centralized credible evidence fusion (CCEF) does. To do so, a privacy-preserving distributed credible evidence fusion method with three-level consensus (PCEF) is proposed in this paper. In evidence difference measure (EDM) neighbor consensus, an evidence-free equivalent expression of EDM among neighbored agents is derived with the shared dot product protocol for pignistic probability and the identical judgment of two events with maximal subjective probabilities, so that evidence privacy is guaranteed due to such irreversible evidence transformation. In EDM network consensus, the non-neighbored EDMs are inferred and neighbored EDMs reach uniformity via interaction between linear average consensus (LAC) and low-rank matrix completion with rank adaptation to guarantee EDM consensus convergence and no solution of inferring raw evidence in numerical iteration style. In fusion network consensus, a privacy-preserving LAC with a self-cancelling differential privacy term is proposed, where each agent adds its randomness to the sharing content and step-by-step cancels such randomness in consensus iterations. Besides, the sufficient condition of the convergence to the CCEF is explored, and it is proven that raw evidence is impossibly inferred in such an iterative consensus. The simulations show that PCEF is close to CCEF both in credibility and fusion results and obtains higher decision accuracy with less time-comsuming than existing methods.

Jun Yan, Nasser Zalmout, Yan Liang et al.

Automatic extraction of product attribute values is an important enabling technology in e-Commerce platforms. This task is usually modeled using sequence labeling architectures, with several extensions to handle multi-attribute extraction. One line of previous work constructs attribute-specific models, through separate decoders or entirely separate models. However, this approach constrains knowledge sharing across different attributes. Other contributions use a single multi-attribute model, with different techniques to embed attribute information. But sharing the entire network parameters across all attributes can limit the model's capacity to capture attribute-specific characteristics. In this paper we present AdaTag, which uses adaptive decoding to handle extraction. We parameterize the decoder with pretrained attribute embeddings, through a hypernetwork and a Mixture-of-Experts (MoE) module. This allows for separate, but semantically correlated, decoders to be generated on the fly for different attributes. This approach facilitates knowledge sharing, while maintaining the specificity of each attribute. Our experiments on a real-world e-Commerce dataset show marked improvements over previous methods.

Le Dong, Zhiyu Lin, Yan Liang et al.

This paper introduces an effective processing framework nominated ICP (Image Cloud Processing) to powerfully cope with the data explosion in image processing field. While most previous researches focus on optimizing the image processing algorithms to gain higher efficiency, our work dedicates to providing a general framework for those image processing algorithms, which can be implemented in parallel so as to achieve a boost in time efficiency without compromising the results performance along with the increasing image scale. The proposed ICP framework consists of two mechanisms, i.e. SICP (Static ICP) and DICP (Dynamic ICP). Specifically, SICP is aimed at processing the big image data pre-stored in the distributed system, while DICP is proposed for dynamic input. To accomplish SICP, two novel data representations named P-Image and Big-Image are designed to cooperate with MapReduce to achieve more optimized configuration and higher efficiency. DICP is implemented through a parallel processing procedure working with the traditional processing mechanism of the distributed system. Representative results of comprehensive experiments on the challenging ImageNet dataset are selected to validate the capacity of our proposed ICP framework over the traditional state-of-the-art methods, both in time efficiency and quality of results.

Lianmeng Jiao, Quan Pan, Yan Liang et al.

The three-dimensional CMKF-U with only position measurements is extended to solve the nonlinear tracking problem with range-rate measurements in this paper. A pseudo measurement is constructed by the product of range and range-rate measurements to reduce the high nonlinearity of the range-rate measurements with respect to the target state; then the mean and covariance of the converted measurement errors are derived by the measurement conditioned method, showing better consistency than the transitional nested conditioning method; finally, the sequential filter was used to process the converted position and range-rate measurements sequentially to reduce the approximation error in the second-order EKF. Monte Carlo simulations show that the performance of the new tracking algorithm is better than the traditional one based on CMKF-D.