Tianming Liu

Sohan Shankar, Yi Pan, Hanqi Jiang et al.

This position and survey paper identifies the emerging convergence of neuroscience, artificial general intelligence (AGI), and neuromorphic computing toward a unified research paradigm. Using a framework grounded in brain physiology, we highlight how synaptic plasticity, sparse spike-based communication, and multimodal association provide design principles for next-generation AGI systems that potentially combine both human and machine intelligences. The review traces this evolution from early connectionist models to state-of-the-art large language models, demonstrating how key innovations like transformer attention, foundation-model pre-training, and multi-agent architectures mirror neurobiological processes like cortical mechanisms, working memory, and episodic consolidation. We then discuss emerging physical substrates capable of breaking the von Neumann bottleneck to achieve brain-scale efficiency in silicon: memristive crossbars, in-memory compute arrays, and emerging quantum and photonic devices. There are four critical challenges at this intersection: 1) integrating spiking dynamics with foundation models, 2) maintaining lifelong plasticity without catastrophic forgetting, 3) unifying language with sensorimotor learning in embodied agents, and 4) enforcing ethical safeguards in advanced neuromorphic autonomous systems. This combined perspective across neuroscience, computation, and hardware offers an integrative agenda for in each of these fields.

Xinyu Liu, Hengyu Liu, Cheng Wang et al.

Endoscopic video generation is crucial for advancing medical imaging and enhancing diagnostic capabilities. However, prior efforts in this field have either focused on static images, lacking the dynamic context required for practical applications, or have relied on unconditional generation that fails to provide meaningful references for clinicians. Therefore, in this paper, we propose the first conditional endoscopic video generation framework, namely EndoGen. Specifically, we build an autoregressive model with a tailored Spatiotemporal Grid-Frame Patterning (SGP) strategy. It reformulates the learning of generating multiple frames as a grid-based image generation pattern, which effectively capitalizes the inherent global dependency modeling capabilities of autoregressive architectures. Furthermore, we propose a Semantic-Aware Token Masking (SAT) mechanism, which enhances the model's ability to produce rich and diverse content by selectively focusing on semantically meaningful regions during the generation process. Through extensive experiments, we demonstrate the effectiveness of our framework in generating high-quality, conditionally guided endoscopic content, and improves the performance of downstream task of polyp segmentation. Code released at https://www.github.com/CUHK-AIM-Group/EndoGen.

Jing Zhang, Xiaowei Yu, Yanjun Lyu et al.

Understanding brain disorders is crucial for accurate clinical diagnosis and treatment. Recent advances in Multimodal Large Language Models (MLLMs) offer a promising approach to interpreting medical images with the support of text descriptions. However, previous research has primarily focused on 2D medical images, leaving richer spatial information of 3D images under-explored, and single-modality-based methods are limited by overlooking the critical clinical information contained in other modalities. To address this issue, this paper proposes Brain-Adapter, a novel approach that incorporates an extra bottleneck layer to learn new knowledge and instill it into the original pre-trained knowledge. The major idea is to incorporate a lightweight bottleneck layer to train fewer parameters while capturing essential information and utilize a Contrastive Language-Image Pre-training (CLIP) strategy to align multimodal data within a unified representation space. Extensive experiments demonstrated the effectiveness of our approach in integrating multimodal data to significantly improve the diagnosis accuracy without high computational costs, highlighting the potential to enhance real-world diagnostic workflows.

Wei Ruan, Tianze Yang, Yifan Zhou et al.

Model merging has achieved significant success, with numerous innovative methods proposed to enhance capabilities by combining multiple models. However, challenges persist due to the lack of a unified framework for classification and systematic comparative analysis, leading to inconsistencies in terminologies and categorizations. Meanwhile, as an increasing number of fine-tuned models are publicly available, their original training data often remain inaccessible due to privacy concerns or intellectual property restrictions. This makes traditional multi-task learning based on shared training data impractical. In scenarios where direct access to training data is infeasible, merging model parameters to create a unified model with broad generalization across multiple domains becomes crucial, further underscoring the importance of model merging techniques. Despite the rapid progress in this field, a comprehensive taxonomy and survey summarizing recent advances and predicting future directions are still lacking. This paper addresses these gaps by establishing a new taxonomy of model merging methods, systematically comparing different approaches, and providing an overview of key developments. By offering a structured perspective on this evolving area, we aim to help newcomers quickly grasp the field's landscape and inspire further innovations.

Jing Zhang, Xiaowei Yu, Tong Chen et al.

The Lewy body dementia (LBD) is the second most common neurodegenerative dementia after Alzheimer's disease (AD). Early differentiation between AD and LBD is crucial because they require different treatment approaches, but this is challenging due to significant clinical overlap, heterogeneity, complex pathogenesis, and the rarity of LBD. While recent advances in artificial intelligence (AI) demonstrate powerful learning capabilities and offer new hope for accurate diagnosis, existing methods primarily focus on designing "neural-level networks". Our work represents a pioneering effort in modeling system-level artificial neural network called BrainNet-MoE for brain modeling and diagnosing. Inspired by the brain's hierarchical organization of bottom-up sensory integration and top-down control, we design a set of disease-specific expert groups to process brain sub-network under different condition, A disease gate mechanism guides the specializa-tion of expert groups, while a transformer layer enables communication be-tween all sub-networks, generating a comprehensive whole-brain represen-tation for downstream disease classification. Experimental results show superior classification accuracy with interpretable insights into how brain sub-networks contribute to different neurodegenerative conditions.

Jing Zhang, Yanjun Lyu, Xiaowei Yu et al.

Dynamic functional connectivity (dFC) using resting-state functional magnetic resonance imaging (rs-fMRI) is an advanced technique for capturing the dynamic changes of neural activities, and can be very useful in the studies of brain diseases such as Alzheimer's disease (AD). Yet, existing studies have not fully leveraged the sequential information embedded within dFC that can potentially provide valuable information when identifying brain conditions. In this paper, we propose a novel framework that jointly learns the embedding of both spatial and temporal information within dFC based on the transformer architecture. Specifically, we first construct dFC networks from rs-fMRI data through a sliding window strategy. Then, we simultaneously employ a temporal block and a spatial block to capture higher-order representations of dynamic spatio-temporal dependencies, via mapping them into an efficient fused feature representation. To further enhance the robustness of these feature representations by reducing the dependency on labeled data, we also introduce a contrastive learning strategy to manipulate different brain states. Experimental results on 345 subjects with 570 scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) demonstrate the superiority of our proposed method for MCI (Mild Cognitive Impairment, the prodromal stage of AD) prediction, highlighting its potential for early identification of AD.

Xiaowei Yu, Jing Zhang, Tong Chen et al.

Lewy Body Disease (LBD) is a common yet understudied form of dementia that imposes a significant burden on public health. It shares clinical similarities with Alzheimer's disease (AD), as both progress through stages of normal cognition, mild cognitive impairment, and dementia. A major obstacle in LBD diagnosis is data scarcity, which limits the effectiveness of deep learning. In contrast, AD datasets are more abundant, offering potential for knowledge transfer. However, LBD and AD data are typically collected from different sites using different machines and protocols, resulting in a distinct domain shift. To effectively leverage AD data while mitigating domain shift, we propose a Transferability Aware Transformer (TAT) that adapts knowledge from AD to enhance LBD diagnosis. Our method utilizes structural connectivity (SC) derived from structural MRI as training data. Built on the attention mechanism, TAT adaptively assigns greater weights to disease-transferable features while suppressing domain-specific ones, thereby reducing domain shift and improving diagnostic accuracy with limited LBD data. The experimental results demonstrate the effectiveness of TAT. To the best of our knowledge, this is the first study to explore domain adaptation from AD to LBD under conditions of data scarcity and domain shift, providing a promising framework for domain-adaptive diagnosis of rare diseases.

Peiran Gu, Fuhao Duan, Wenhao Li et al.

In recent years, the development of Large Language Models (LLMs) has made significant breakthroughs in the field of natural language processing and has gradually been applied to the field of humanities and social sciences research. LLMs have a wide range of application value in the field of humanities and social sciences because of its strong text understanding, generation and reasoning capabilities. In humanities and social sciences research, LLMs can analyze large-scale text data and make inferences. This article analyzes the large language model DeepSeek-R1 from seven aspects: low-resource language translation, educational question-answering, student writing improvement in higher education, logical reasoning, educational measurement and psychometrics, public health policy analysis, and art education . Then we compare the answers given by DeepSeek-R1 in the seven aspects with the answers given by o1-preview. DeepSeek-R1 performs well in the humanities and social sciences, answering most questions correctly and logically, and can give reasonable analysis processes and explanations. Compared with o1-preview, it can automatically generate reasoning processes and provide more detailed explanations, which is suitable for beginners or people who need to have a detailed understanding of this knowledge, while o1-preview is more suitable for quick reading. Through analysis, it is found that LLM has broad application potential in the field of humanities and social sciences, and shows great advantages in improving text analysis efficiency, language communication and other fields. LLM's powerful language understanding and generation capabilities enable it to deeply explore complex problems in the field of humanities and social sciences, and provide innovative tools for academic research and practical applications.

Minheng Chen, Chao Cao, Tong Chen et al.

The 3-hinge gyrus (3HG) is a newly defined folding pattern, which is the conjunction of gyri coming from three directions in cortical folding. Many studies demonstrated that 3HGs can be reliable nodes when constructing brain networks or connectome since they simultaneously possess commonality and individuality across different individual brains and populations. However, 3HGs are identified and validated within individual spaces, making it difficult to directly serve as the brain network nodes due to the absence of cross-subject correspondence. The 3HG correspondences represent the intrinsic regulation of brain organizational architecture, traditional image-based registration methods tend to fail because individual anatomical properties need to be fully respected. To address this challenge, we propose a novel self-supervised framework for anatomical feature embedding of the 3HGs to build the correspondences among different brains. The core component of this framework is to construct a structural similarity-enhanced multi-hop feature encoding strategy based on the recently developed Kolmogorov-Arnold network (KAN) for anatomical feature embedding. Extensive experiments suggest that our approach can effectively establish robust cross-subject correspondences when no one-to-one mapping exists.

Kelli Henry, Steven Xu, Kaitlin Blotske et al.

Purpose: Large language models (LLMs) have proven performance for certain diagnostic tasks, however limited studies have evaluated their consistency in recommending appropriate medication regimens for a given diagnosis. Medication management is a complex task that requires synthesis of drug formulation and complete order instructions for safe use. Here, the performance of GPT 4o, an LLM available with ChatGPT, was tested for three medication management tasks. Methods: GPT-4o performance was tested using three medication tasks: identifying available formulations for a given generic drug name, identifying drug-drug interactions (DDI) for a given medication regimen, and preparing a medication order for a given generic drug name. For each experiment, the models raw text response was captured exactly as returned and evaluated using clinician evaluation in addition to standard LLM metrics, including Term Frequency-Inverse Document Frequency (TF IDF) vectors, normalized Levenshtein similarity, and Recall-Oriented Understudy for Gisting Evaluation (ROUGE 1/ROUGE L F1) between each response and its reference string. Results: For the first task of drug-formulation matching, GPT-4o had 49% accuracy for generic medications being matched to all available formulations, with an average of 1.23 omissions per medication and 1.14 hallucinations per medication. For the second task of drug-drug interaction identification, the accuracy was 54.7% for identifying the DDI pair. For the third task, GPT-4o generated order sentences containing no medication or abbreviation errors in 65.8% of cases. Conclusions: Model performance for basic medication tasks was consistently poor. This evaluation highlights the need for domain-specific training through clinician-annotated datasets and a comprehensive evaluation framework for benchmarking performance.

Jing Zhang, Xiaowei Yu, Minheng Chen et al.

Integrating brain imaging data with clinical reports offers a valuable opportunity to leverage complementary multimodal information for more effective and timely diagnosis in practical clinical settings. This approach has gained significant attention in brain disorder research, yet a key challenge remains: how to effectively link objective imaging data with subjective text-based reports, such as doctors' notes. In this work, we propose a novel framework that aligns brain connectomes with clinical reports in a shared cross-modal latent space at both the subject and connectome levels, thereby enhancing representation learning. The key innovation of our approach is that we treat brain subnetworks as tokens of imaging data, rather than raw image patches, to align with word tokens in clinical reports. This enables a more efficient identification of system-level associations between neuroimaging findings and clinical observations, which is critical since brain disorders often manifest as network-level abnormalities rather than isolated regional alterations. We applied our method to mild cognitive impairment (MCI) using the ADNI dataset. Our approach not only achieves state-of-the-art predictive performance but also identifies clinically meaningful connectome-text pairs, offering new insights into the early mechanisms of Alzheimer's disease and supporting the development of clinically useful multimodal biomarkers.

Yige Li, Peihai Jiang, Jun Sun et al.

Large Language Models (LLMs) have demonstrated significant success across diverse applications. However, enforcing content restrictions remains a significant challenge due to their expansive output space. One aspect of content restriction is preventing LLMs from generating harmful content via model alignment approaches such as supervised fine-tuning (SFT). Yet, the need for content restriction may vary significantly across user groups, change rapidly over time, and not always align with general definitions of harmfulness. Applying SFT to each of these specific use cases is impractical due to the high computational, data, and storage demands. Motivated by this need, we propose a new task called \textit{Adaptive Content Restriction} (AdaCoRe), which focuses on lightweight strategies -- methods without model fine-tuning -- to prevent deployed LLMs from generating restricted terms for specific use cases. We propose the first method for AdaCoRe, named \textit{Suffix Optimization (SOP)}, which appends a short, optimized suffix to any prompt to a) prevent a target LLM from generating a set of restricted terms, while b) preserving the output quality. To evaluate AdaCoRe approaches, including our SOP, we create a new \textit{Content Restriction Benchmark} (CoReBench), which contains 400 prompts for 80 restricted terms across 8 carefully selected categories. We demonstrate the effectiveness of SOP on CoReBench, which outperforms the system-level baselines such as system suffix by 15\%, 17\%, 10\%, 9\%, and 6\% on average restriction rates for Gemma2-2B, Mistral-7B, Vicuna-7B, Llama3-8B, and Llama3.1-8B, respectively. We also demonstrate that SOP is effective on POE, an online platform hosting various commercial LLMs, highlighting its practicality in real-world scenarios.

Yifei Sun, Daniel Chahine, Qinghao Wen et al.

Understanding brain dynamics is important for neuroscience and mental health. Functional magnetic resonance imaging (fMRI) enables the measurement of neural activities through blood-oxygen-level-dependent (BOLD) signals, which represent brain states. In this study, we aim to predict future human resting brain states with fMRI. Due to the 3D voxel-wise spatial organization and temporal dependencies of the fMRI data, we propose a novel architecture which employs a 4D Shifted Window (Swin) Transformer as encoder to efficiently learn spatio-temporal information and a convolutional decoder to enable brain state prediction at the same spatial and temporal resolution as the input fMRI data. We used 100 unrelated subjects from the Human Connectome Project (HCP) for model training and testing. Our novel model has shown high accuracy when predicting 7.2s resting-state brain activities based on the prior 23.04s fMRI time series. The predicted brain states highly resemble BOLD contrast and dynamics. This work shows promising evidence that the spatiotemporal organization of the human brain can be learned by a Swin Transformer model, at high resolution, which provides a potential for reducing the fMRI scan time and the development of brain-computer interfaces in the future.

Lu Zhang, Li Wang, Tianming Liu et al.

For decades, a variety of predictive approaches have been proposed and evaluated in terms of their prediction capability for Alzheimer's Disease (AD) and its precursor - mild cognitive impairment (MCI). Most of them focused on prediction or identification of statistical differences among different clinical groups or phases (e.g., longitudinal studies). The continuous nature of AD development and transition states between successive AD related stages have been overlooked, especially in binary or multi-class classification. Though a few progression models of AD have been studied recently, they were mainly designed to determine and compare the order of specific biomarkers. How to effectively predict the individual patient's status within a wide spectrum of continuous AD progression has been largely overlooked. In this work, we developed a novel learning-based embedding framework to encode the intrinsic relations among AD related clinical stages by a set of meaningful embedding vectors in the latent space (Disease2Vec). We named this process as disease embedding. By disease em-bedding, the framework generates a disease embedding tree (DETree) which effectively represents different clinical stages as a tree trajectory reflecting AD progression and thus can be used to predict clinical status by projecting individuals onto this continuous trajectory. Through this model, DETree can not only perform efficient and accurate prediction for patients at any stages of AD development (across five clinical groups instead of typical two groups), but also provide richer status information by examining the projecting locations within a wide and continuous AD progression process.