Xin Deng

Bin Liu, Siqi Wu, Jin Wang et al.

The discovery of drug-target interactions (DTIs) plays a crucial role in pharmaceutical development. The deep learning model achieves more accurate results in DTI prediction due to its ability to extract robust and expressive features from drug and target chemical structures. However, existing deep learning methods typically generate drug features via aggregating molecular atom representations, ignoring the chemical properties carried by motifs, i.e., substructures of the molecular graph. The atom-drug double-level molecular representation learning can not fully exploit structure information and fails to interpret the DTI mechanism from the motif perspective. In addition, sequential model-based target feature extraction either fuses limited contextual information or requires expensive computational resources. To tackle the above issues, we propose a hierarchical graph representation learning-based DTI prediction method (HiGraphDTI). Specifically, HiGraphDTI learns hierarchical drug representations from triple-level molecular graphs to thoroughly exploit chemical information embedded in atoms, motifs, and molecules. Then, an attentional feature fusion module incorporates information from different receptive fields to extract expressive target features.Last, the hierarchical attention mechanism identifies crucial molecular segments, which offers complementary views for interpreting interaction mechanisms. The experiment results not only demonstrate the superiority of HiGraphDTI to the state-of-the-art methods, but also confirm the practical ability of our model in interaction interpretation and new DTI discovery.

Jingyi Xu, Meisong Zheng, Ying Chen et al.

Diffusion model (DM) based Video Super-Resolution (VSR) approaches achieve impressive perceptual quality. However, they suffer from error accumulation, spatial artifacts, and a trade-off between perceptual quality and fidelity, primarily caused by inaccurate alignment and insufficient compensation between video frames. In this paper, within the DM-based VSR pipeline, we revisit the role of alignment and compensation between adjacent video frames and reveal two crucial observations: (a) the feature domain is better suited than the pixel domain for information compensation due to its stronger spatial and temporal correlations, and (b) warping at an upscaled resolution better preserves high-frequency information, but this benefit is not necessarily monotonic. Therefore, we propose a novel Densely Guided diffusion model with Aligned Features for Video Super-Resolution (DGAF-VSR), with an Optical Guided Warping Module (OGWM) to maintain high-frequency details in the aligned features and a Feature-wise Temporal Condition Module (FTCM) to deliver dense guidance in the feature domain. Extensive experiments on synthetic and real-world datasets demonstrate that DGAF-VSR surpasses state-of-the-art methods in key aspects of VSR, including perceptual quality (35.82\% DISTS reduction), fidelity (0.20 dB PSNR gain), and temporal consistency (30.37\% tLPIPS reduction).

Xin Deng, Ross Smith, Genevieve Quintin

With the evolution of the cloud and customer centric culture, we inherently accumulate huge repositories of textual reviews, feedback, and support data.This has driven enterprises to seek and research engagement patterns, user network analysis, topic detections, etc.However, huge manual work is still necessary to mine data to be able to mine actionable outcomes. In this paper, we proposed and developed an innovative Semi-Supervised Learning approach by utilizing Deep Learning and Topic Modeling to have a better understanding of the user voice.This approach combines a BERT-based multiclassification algorithm through supervised learning combined with a novel Probabilistic and Semantic Hybrid Topic Inference (PSHTI) Model through unsupervised learning, aiming at automating the process of better identifying the main topics or areas as well as the sub-topics from the textual feedback and support.There are three major break-through: 1. As the advancement of deep learning technology, there have been tremendous innovations in the NLP field, yet the traditional topic modeling as one of the NLP applications lag behind the tide of deep learning. In the methodology and technical perspective, we adopt transfer learning to fine-tune a BERT-based multiclassification system to categorize the main topics and then utilize the novel PSHTI model to infer the sub-topics under the predicted main topics. 2. The traditional unsupervised learning-based topic models or clustering methods suffer from the difficulty of automatically generating a meaningful topic label, but our system enables mapping the top words to the self-help issues by utilizing domain knowledge about the product through web-crawling. 3. This work provides a prominent showcase by leveraging the state-of-the-art methodology in the real production to help shed light to discover user insights and drive business investment priorities.