Chang Liu

Chang Liu, Xiangrui Zeng, Kaiwen Wang et al.

Cellular Electron Cryo-Tomography (CECT) is a powerful 3D imaging tool for studying the native structure and organization of macromolecules inside single cells. For systematic recognition and recovery of macromolecular structures captured by CECT, methods for several important tasks such as subtomogram classification and semantic segmentation have been developed. However, the recognition and recovery of macromolecular structures are still very difficult due to high molecular structural diversity, crowding molecular environment, and the imaging limitations of CECT. In this paper, we propose a novel multi-task 3D convolutional neural network model for simultaneous classification, segmentation, and coarse structural recovery of macromolecules of interest in subtomograms. In our model, the learned image features of one task are shared and thereby mutually reinforce the learning of other tasks. Evaluated on realistically simulated and experimental CECT data, our multi-task learning model outperformed all single-task learning methods for classification and segmentation. In addition, we demonstrate that our model can generalize to discover, segment and recover novel structures that do not exist in the training data.

Shun Yang, Wenshuo Wang, Chang Liu et al.

Deep learning-based approaches have been widely used for training controllers for autonomous vehicles due to their powerful ability to approximate nonlinear functions or policies. However, the training process usually requires large labeled data sets and takes a lot of time. In this paper, we analyze the influences of features on the performance of controllers trained using the convolutional neural networks (CNNs), which gives a guideline of feature selection to reduce computation cost. We collect a large set of data using The Open Racing Car Simulator (TORCS) and classify the image features into three categories (sky-related, roadside-related, and road-related features).We then design two experimental frameworks to investigate the importance of each single feature for training a CNN controller.The first framework uses the training data with all three features included to train a controller, which is then tested with data that has one feature removed to evaluate the feature's effects. The second framework is trained with the data that has one feature excluded, while all three features are included in the test data. Different driving scenarios are selected to test and analyze the trained controllers using the two experimental frameworks. The experiment results show that (1) the road-related features are indispensable for training the controller, (2) the roadside-related features are useful to improve the generalizability of the controller to scenarios with complicated roadside information, and (3) the sky-related features have limited contribution to train an end-to-end autonomous vehicle controller.