Yuyao Zhang

Xuanyu Tian, Qing Wu, Hongjiang Wei et al.

Fluorescence microscopy is a key driver to promote discoveries of biomedical research. However, with the limitation of microscope hardware and characteristics of the observed samples, the fluorescence microscopy images are susceptible to noise. Recently, a few self-supervised deep learning (DL) denoising methods have been proposed. However, the training efficiency and denoising performance of existing methods are relatively low in real scene noise removal. To address this issue, this paper proposed self-supervised image denoising method Noise2SR (N2SR) to train a simple and effective image denoising model based on single noisy observation. Our Noise2SR denoising model is designed for training with paired noisy images of different dimensions. Benefiting from this training strategy, Noise2SR is more efficiently self-supervised and able to restore more image details from a single noisy observation. Experimental results of simulated noise and real microscopy noise removal show that Noise2SR outperforms two blind-spot based self-supervised deep learning image denoising methods. We envision that Noise2SR has the potential to improve more other kind of scientific imaging quality.

Xuanyu Tian, Lixuan Chen, Qing Wu et al.

Emerging unsupervised implicit neural representation (INR) methods, such as NeRP, NeAT, and SCOPE, have shown great potential to address sparse-view computed tomography (SVCT) inverse problems. Although these INR-based methods perform well in relatively dense SVCT reconstructions, they struggle to achieve comparable performance to supervised methods in sparser SVCT scenarios. They are prone to being affected by noise, limiting their applicability in real clinical settings. Additionally, current methods have not fully explored the use of image domain priors for solving SVCsT inverse problems. In this work, we demonstrate that imperfect reconstruction results can provide effective image domain priors for INRs to enhance performance. To leverage this, we introduce Self-prior embedding neural representation (Spener), a novel unsupervised method for SVCT reconstruction that integrates iterative reconstruction algorithms. During each iteration, Spener extracts local image prior features from the previous iteration and embeds them to constrain the solution space. Experimental results on multiple CT datasets show that our unsupervised Spener method achieves performance comparable to supervised state-of-the-art (SOTA) methods on in-domain data while outperforming them on out-of-domain datasets. Moreover, Spener significantly improves the performance of INR-based methods in handling SVCT with noisy sinograms. Our code is available at https://github.com/MeijiTian/Spener.

Junlan Feng, Fanyu Meng, Chong Long et al.

The hallucination and credibility concerns of large language models (LLMs) are global challenges that the industry is collectively addressing. Recently, a significant amount of advances have been made on post-training and inference techniques to mitigate these challenges. However, it is widely agreed that unsafe and hallucinations of LLMs intrinsically originate from pre-training, involving pre-training data and the next-token prediction learning mechanism. In this paper, we focus on enhancing pre-training data to improve the trustworthiness and safety of LLMs. Since the data is vast, it's almost impossible to entirely purge the data of factual errors, logical inconsistencies, or distributional biases. Moreover, the pre-training data lack grounding in real-world knowledge. Each piece of data is treated as a sequence of tokens rather than as a representation of a part of the world. To overcome these issues, we propose approaches to enhancing our pre-training data with its context in the world and increasing a substantial amount of data reflecting industrial scenarios. We argue that most source data are created by the authors for specific purposes in a certain spatial-temporal context. They have played a role in the real world. By incorporating related world context information, we aim to better anchor pre-training data within real-world scenarios, thereby reducing uncertainty in model training and enhancing the model's safety and trustworthiness. We refer to our Data with World Context as DWC. We continue pre-training an earlier checkpoint of JT-35B-Base with 1.5 trillion of DWC tokens. We introduce our post-training procedures to activate the potentials of DWC. Compared with the Qwen model of a similar scale, JT-Safe-35B achieves an average performance improvement of 1.79% on the Safety and Trustworthy evaluation benchmarks, while being pretrained with only 6.2 trillion tokens.

Xuanyu Tian, Zhuoya Dong, Xiyue Lin et al.

High-resolution electron microscopy (HREM) imaging technique is a powerful tool for directly visualizing a broad range of materials in real-space. However, it faces challenges in denoising due to ultra-low signal-to-noise ratio (SNR) and scarce data availability. In this work, we propose Noise2SR, a zero-shot self-supervised learning (ZS-SSL) denoising framework for HREM. Within our framework, we propose a super-resolution (SR) based self-supervised training strategy, incorporating the Random Sub-sampler module. The Random Sub-sampler is designed to generate approximate infinite noisy pairs from a single noisy image, serving as an effective data augmentation in zero-shot denoising. Noise2SR trains the network with paired noisy images of different resolutions, which is conducted via SR strategy. The SR-based training facilitates the network adopting more pixels for supervision, and the random sub-sampling helps compel the network to learn continuous signals enhancing the robustness. Meanwhile, we mitigate the uncertainty caused by random-sampling by adopting minimum mean squared error (MMSE) estimation for the denoised results. With the distinctive integration of training strategy and proposed designs, Noise2SR can achieve superior denoising performance using a single noisy HREM image. We evaluate the performance of Noise2SR in both simulated and real HREM denoising tasks. It outperforms state-of-the-art ZS-SSL methods and achieves comparable denoising performance with supervised methods. The success of Noise2SR suggests its potential for improving the SNR of images in material imaging domains.