Fan Hu

Xirong Li, Aozhu Chen, Ziyue Wang et al.

We summarize our TRECVID 2022 Ad-hoc Video Search (AVS) experiments. Our solution is built with two new techniques, namely Lightweight Attentional Feature Fusion (LAFF) for combining diverse visual / textual features and Bidirectional Negation Learning (BNL) for addressing queries that contain negation cues. In particular, LAFF performs feature fusion at both early and late stages and at both text and video ends to exploit diverse (off-the-shelf) features. Compared to multi-head self attention, LAFF is much more compact yet more effective. Its attentional weights can also be used for selecting fewer features, with the retrieval performance mostly preserved. BNL trains a negation-aware video retrieval model by minimizing a bidirectionally constrained loss per triplet, where a triplet consists of a given training video, its original description and a partially negated description. For video feature extraction, we use pre-trained CLIP, BLIP, BEiT, ResNeXt-101 and irCSN. As for text features, we adopt bag-of-words, word2vec, CLIP and BLIP. Our training data consists of MSR-VTT, TGIF and VATEX that were used in our previous participation. In addition, we automatically caption the V3C1 collection for pre-training. The 2022 edition of the TRECVID benchmark has again been a fruitful participation for the RUCMM team. Our best run, with an infAP of 0.262, is ranked at the second place teamwise.

Fan Hu, Dongqi Wang, Huazhen Huang et al.

Drug discovery is vitally important for protecting human against disease. Target-based screening is one of the most popular methods to develop new drugs in the past several decades. This method efficiently screens candidate drugs inhibiting target protein in vitro, but it often fails due to inadequate activity of the selected drugs in vivo. Accurate computational methods are needed to bridge this gap. Here, we propose a novel graph multi task deep learning model to identify compounds carrying both target inhibitory and cell active (MATIC) properties. On a carefully curated SARS-CoV-2 dataset, the proposed MATIC model shows advantages comparing with traditional method in screening effective compounds in vivo. Next, we explored the model interpretability and found that the learned features for target inhibition (in vitro) or cell active (in vivo) tasks are different with molecular property correlations and atom functional attentions. Based on these findings, we utilized a monte carlo based reinforcement learning generative model to generate novel multi-property compounds with both in vitro and in vivo efficacy, thus bridging the gap between target-based and cell-based drug discovery.

Fan Hu, Aozhu Chen, Xirong Li

While deep learning based image retrieval is reported to be vulnerable to adversarial attacks, existing works are mainly on image-to-image retrieval with their attacks performed at the front end via query modification. By contrast, we present in this paper the first study about a threat that occurs at the back end of a text-to-image retrieval (T2IR) system. Our study is motivated by the fact that the image collection indexed by the system will be regularly updated due to the arrival of new images from various sources such as web crawlers and advertisers. With malicious images indexed, it is possible for an attacker to indirectly interfere with the retrieval process, letting users see certain images that are completely irrelevant w.r.t. their queries. We put this thought into practice by proposing a novel Trojan-horse attack (THA). In particular, we construct a set of Trojan-horse images by first embedding word-specific adversarial information into a QR code and then putting the code on benign advertising images. A proof-of-concept evaluation, conducted on two popular T2IR datasets (Flickr30k and MS-COCO), shows the effectiveness of the proposed THA in a white-box mode.

Fan Hu, Aozhu Chen, Ziyue Wang et al.

In this paper we revisit feature fusion, an old-fashioned topic, in the new context of text-to-video retrieval. Different from previous research that considers feature fusion only at one end, let it be video or text, we aim for feature fusion for both ends within a unified framework. We hypothesize that optimizing the convex combination of the features is preferred to modeling their correlations by computationally heavy multi-head self attention. We propose Lightweight Attentional Feature Fusion (LAFF). LAFF performs feature fusion at both early and late stages and at both video and text ends, making it a powerful method for exploiting diverse (off-the-shelf) features. The interpretability of LAFF can be used for feature selection. Extensive experiments on five public benchmark sets (MSR-VTT, MSVD, TGIF, VATEX and TRECVID AVS 2016-2020) justify LAFF as a new baseline for text-to-video retrieval.