Hao He

Hao He, Chao Li, Wolfgang Ganglberger et al.

The ability to assess sleep at home, capture sleep stages, and detect the occurrence of apnea (without on-body sensors) simply by analyzing the radio waves bouncing off people's bodies while they sleep is quite powerful. Such a capability would allow for longitudinal data collection in patients' homes, informing our understanding of sleep and its interaction with various diseases and their therapeutic responses, both in clinical trials and routine care. In this article, we develop an advanced machine learning algorithm for passively monitoring sleep and nocturnal breathing from radio waves reflected off people while asleep. Validation results in comparison with the gold standard (i.e., polysomnography) (n=849) demonstrate that the model captures the sleep hypnogram (with an accuracy of 81% for 30-second epochs categorized into Wake, Light Sleep, Deep Sleep, or REM), detects sleep apnea (AUROC = 0.88), and measures the patient's Apnea-Hypopnea Index (ICC=0.95; 95% CI = [0.93, 0.97]). Notably, the model exhibits equitable performance across race, sex, and age. Moreover, the model uncovers informative interactions between sleep stages and a range of diseases including neurological, psychiatric, cardiovascular, and immunological disorders. These findings not only hold promise for clinical practice and interventional trials but also underscore the significance of sleep as a fundamental component in understanding and managing various diseases.

Shengjun Pan, Brendan Kitts, Tian Zhou et al.

This paper describes a new win-rate based bid shading algorithm (WR) that does not rely on the minimum-bid-to-win feedback from a Sell-Side Platform (SSP). The method uses a modified logistic regression to predict the profit from each possible shaded bid price. The function form allows fast maximization at run-time, a key requirement for Real-Time Bidding (RTB) systems. We report production results from this method along with several other algorithms. We found that bid shading, in general, can deliver significant value to advertisers, reducing price per impression to about 55% of the unshaded cost. Further, the particular approach described in this paper captures 7% more profit for advertisers, than do benchmark methods of just bidding the most probable winning price. We also report 4.3% higher surplus than an industry Sell-Side Platform shading service. Furthermore, we observed 3% - 7% lower eCPM, eCPC and eCPA when the algorithm was integrated with budget controllers. We attribute the gains above as being mainly due to the explicit maximization of the surplus function, and note that other algorithms can take advantage of this same approach.