Limei Peng

Yan Jiao, Jingran Xu, Pin-Han Ho et al.

Cross-domain knowledge alignment is essential for integrating heterogeneous medical systems, yet existing approaches typically treat entity alignment as a static matching problem, ignoring query context and cross-system asymmetry. This limitation is particularly critical in integrative medical settings, where correspondence between concepts is inherently context-dependent, non-bijective, and direction-sensitive. In this paper, we propose Query-Conditioned Entity Alignment (QCEA), which reformulates entity alignment as a query-conditioned correspondence problem. Instead of learning a fixed mapping between entity representations, QCEA treats the textual description of a source entity as a query and ranks candidate entities in the target graph, enabling context-dependent alignment. The framework integrates semantic encoding, graph-based representation learning, and a direction-aware transformation module to capture asymmetric and many-to-many correspondence across heterogeneous knowledge systems. We evaluate QCEA on TCM--WM knowledge graphs derived from SymMap, covering both symptom alignment and herb--molecule alignment tasks. Experimental results show consistent improvements over representative baselines, particularly on rank-sensitive metrics such as Hit@K and MRR. Furthermore, downstream retrieval-augmented generation (RAG) experiments demonstrate that improved alignment leads to better evidence retrieval, stronger grounding, and higher answer accuracy. These findings highlight that alignment is not merely a data integration step, but a key factor that shapes knowledge accessibility and reliability in cross-system medical reasoning.

Chenxin Yuan, Shoupeng Chen, Haojiang Ye et al.

Accurate segmentation of 3D medical scans is crucial for clinical diagnostics and treatment planning, yet existing methods often fail to achieve both high accuracy and computational efficiency across diverse anatomies and imaging modalities. To address these challenges, we propose GCNV-Net, a novel 3D medical segmentation framework that integrates a Tri-directional Dynamic Nonvoid Voxel Transformer (3DNVT), a Geometrical Cross-Attention module (GCA), and Nonvoid Voxelization. The 3DNVT dynamically partitions relevant voxels along the three orthogonal anatomical planes, namely the transverse, sagittal, and coronal planes, enabling effective modeling of complex 3D spatial dependencies. The GCA mechanism explicitly incorporates geometric positional information during multi-scale feature fusion, significantly enhancing fine-grained anatomical segmentation accuracy. Meanwhile, Nonvoid Voxelization processes only informative regions, greatly reducing redundant computation without compromising segmentation quality, and achieves a 56.13% reduction in FLOPs and a 68.49% reduction in inference latency compared to conventional voxelization. We evaluate GCNV-Net on multiple widely used benchmarks: BraTS2021, ACDC, MSD Prostate, MSD Pancreas, and AMOS2022. Our method achieves state-of-the-art segmentation performance across all datasets, outperforming the best existing methods by 0.65% on Dice, 0.63% on IoU, 1% on NSD, and relatively 14.5% on HD95. All results demonstrate that GCNV-Net effectively balances accuracy and efficiency, and its robustness across diverse organs, disease conditions, and imaging modalities highlights strong potential for clinical deployment.

Dun Liu, Qin Pang, Guangai Liu et al.

The effectiveness of artificial intelligence (AI) in healthcare is significantly hindered by unstructured clinical documentation, which results in noisy, inconsistent, and logically fragmented training data. To address this challenge, we present a knowledge-driven framework that integrates the standardized clinical terminology SNOMED CT with the Neo4j graph database to construct a structured medical knowledge graph. In this graph, clinical entities such as diseases, symptoms, and medications are represented as nodes, and semantic relationships such as ``caused by,'' ``treats,'' and ``belongs to'' are modeled as edges in Neo4j, with types mapped from formal SNOMED CT relationship concepts (e.g., \texttt{Causative agent}, \texttt{Indicated for}). This design enables multi-hop reasoning and ensures terminological consistency. By extracting and standardizing entity-relationship pairs from clinical texts, we generate structured, JSON-formatted datasets that embed explicit diagnostic pathways. These datasets are used to fine-tune large language models (LLMs), significantly improving the clinical logic consistency of their outputs. Experimental results demonstrate that our knowledge-guided approach enhances the validity and interpretability of AI-generated diagnostic reasoning, providing a scalable solution for building reliable AI-assisted clinical systems.