Lei Yu

Honghui Zhang, Chenmeinian Guo, Yichen Yu et al.

Multimodal retail agents should not only recognize what a customer is doing, but also decide whether and how to assist before an explicit request is made. We study this setting through the See--Infer--Intervene (SII) framework, where a device must see pre-interaction behavior, infer latent customer intent, and act by selecting an appropriate service intervention or choosing to wait. We instantiate SII with the Proactive Intent World Model (PIWM), which represents customer state with AIDA (Attention, Interest, Desire, Action) purchasing phases and BDI (belief, desire, intention) psychological fields, predicts action-conditioned intent transitions, and selects from five response classes: Greet, Elicit, Inform, Recommend, and Hold. We further construct GuidanceSalesBench, a smart-retail benchmark containing state manifests, pre-interaction videos, candidate responses, action-conditioned outcomes, and best-action labels. When conditioned on ground-truth customer state to isolate action selection, PIWM achieves 0.641 macro F1 on 30 held-out target videos, outperforming a zero-shot Qwen2.5-VL-7B baseline and training variants without balanced action supervision; end-to-end video-only selection drops to 0.295, below the 5-class balanced random baseline of 0.414, identifying video-to-state grounding as the dominant deployment-time bottleneck. A preliminary staged real-store pilot (recorded with paid participants performing scripted customer behaviors) reaches 0.579 action macro F1 on 20 fully annotated videos, with 10 additional accessible videos released with index-level labels.

Jingquan Yan, Yuwei Miao, Lei Yu et al.

Exploring how genetic sequences shape phenotypes is a fundamental challenge in biology and a key step toward scalable, hypothesis-driven experimentation. The task is complicated by the large modality gap between sequences and phenotypes, as well as the pleiotropic nature of gene-phenotype relationships. Existing sequence-based efforts focus on the degree to which variants of specific genes alter a limited set of phenotypes, while general gene knockout induced phenotype abnormality prediction methods heavily rely on curated genetic information as inputs, which limits scalability and generalizability. As a result, the task of broadly predicting the presence of multiple phenotype abnormalities under gene knockout directly from gene sequences remains underexplored. We introduce GenePheno, the first interpretable multi-label prediction framework that predicts knockout induced phenotypic abnormalities from gene sequences. GenePheno employs a contrastive multi-label learning objective that captures inter-phenotype correlations, complemented by an exclusive regularization that enforces biological consistency. It further incorporates a gene function bottleneck layer, offering human interpretable concepts that reflect functional mechanisms behind phenotype formation. To support progress in this area, we curate four datasets with canonical gene sequences as input and multi-label phenotypic abnormalities induced by gene knockouts as targets. Across these datasets, GenePheno achieves state-of-the-art gene-centric $F_{\text{max}}$ and phenotype-centric AUC, and case studies demonstrate its ability to reveal gene functional mechanisms.