Yaqin Zhang

Tongda Xu, Han Gao, Chenjian Gao et al.

In this paper, we consider the problem of bit allocation in Neural Video Compression (NVC). First, we reveal a fundamental relationship between bit allocation in NVC and Semi-Amortized Variational Inference (SAVI). Specifically, we show that SAVI with GoP (Group-of-Picture)-level likelihood is equivalent to pixel-level bit allocation with precise rate \& quality dependency model. Based on this equivalence, we establish a new paradigm of bit allocation using SAVI. Different from previous bit allocation methods, our approach requires no empirical model and is thus optimal. Moreover, as the original SAVI using gradient ascent only applies to single-level latent, we extend the SAVI to multi-level such as NVC by recursively applying back-propagating through gradient ascent. Finally, we propose a tractable approximation for practical implementation. Our method can be applied to scenarios where performance outweights encoding speed, and serves as an empirical bound on the R-D performance of bit allocation. Experimental results show that current state-of-the-art bit allocation algorithms still have a room of $\approx 0.5$ dB PSNR to improve compared with ours. Code is available at \url{https://github.com/tongdaxu/Bit-Allocation-Using-Optimization}.

Jianhui Wang, Wenyu Zhu, Bowen Gao et al.

Protein-ligand binding prediction is central to virtual screening and affinity ranking, two fundamental tasks in drug discovery. While recent retrieval-based methods embed ligands and protein pockets into Euclidean space for similarity-based search, the geometry of Euclidean embeddings often fails to capture the hierarchical structure and fine-grained affinity variations intrinsic to molecular interactions. In this work, we propose HypSeek, a hyperbolic representation learning framework that embeds ligands, protein pockets, and sequences into Lorentz-model hyperbolic space. By leveraging the exponential geometry and negative curvature of hyperbolic space, HypSeek enables expressive, affinity-sensitive embeddings that can effectively model both global activity and subtle functional differences-particularly in challenging cases such as activity cliffs, where structurally similar ligands exhibit large affinity gaps. Our mode unifies virtual screening and affinity ranking in a single framework, introducing a protein-guided three-tower architecture to enhance representational structure. HypSeek improves early enrichment in virtual screening on DUD-E from 42.63 to 51.44 (+20.7%) and affinity ranking correlation on JACS from 0.5774 to 0.7239 (+25.4%), demonstrating the benefits of hyperbolic geometry across both tasks and highlighting its potential as a powerful inductive bias for protein-ligand modeling.

Meiyu Huang, Yao Xu, Lixin Qian et al.

Deep learning techniques have made an increasing impact on the field of remote sensing. However, deep neural networks based fusion of multimodal data from different remote sensors with heterogenous characteristics has not been fully explored, due to the lack of availability of big amounts of perfectly aligned multi-sensor image data with diverse scenes of high resolutions, especially for synthetic aperture radar (SAR) data and optical imagery. To promote the development of deep learning based SAR-optical fusion approaches, we release the QXS-SAROPT dataset, which contains 20,000 pairs of SAR-optical image patches. We obtain the SAR patches from SAR satellite GaoFen-3 images and the optical patches from Google Earth images. These images cover three port cities: San Diego, Shanghai and Qingdao. Here, we present a detailed introduction of the construction of the dataset, and show its two representative exemplary applications, namely SAR-optical image matching and SAR ship detection boosted by cross-modal information from optical images. As a large open SAR-optical dataset with multiple scenes of a high resolution, we believe QXS-SAROPT will be of potential value for further research in SAR-optical data fusion technology based on deep learning.