Shuhui Wang

Wei Dai, Ziyao Zhang, Lixia Tian et al.

In neuroimaging analysis, fMRI can well assess the function changes for brain diseases with no obvious structural lesions. To date, most deep-learning-based fMRI studies have employed functional connectivity (FC) as the basic feature for disease classification. However, FC is calculated on time series of predefined regions of interest and neglects detailed information contained in each voxel. Another drawback of using FC is the limited sample size for the training of deep models. The low representation ability of FC leads to poor performance in clinical practice, especially when dealing with multimodal medical data involving multiple types of visual signals and textual records for brain diseases. To overcome this bottleneck problem in the fMRI feature modality, we propose BrainFormer, an end-to-end functional interaction learning method for brain disease classification with single fMRI volume. Unlike traditional deep learning methods that construct convolution and transformers on FC, BrainFormer learns the functional interaction from fMRI signals, by modeling the local cues within each voxel with 3D convolutions and capturing the global correlations among distant regions with specially designed global attention mechanisms from shallow layers to deep layers. Meanwhile, BrainFormer can deal with multimodal medical data including fMRI volume, structural MRI, FC features and phenotypic data to achieve more comprehensive brain disease diagnosis. We evaluate BrainFormer on five independent multi-site datasets on autism, Alzheimer's disease, depression, attention deficit hyperactivity disorder and headache disorders. The results demonstrate its effectiveness and generalizability for multiple brain diseases diagnosis with multimodal features. BrainFormer may promote precision of neuroimaging-based diagnosis in clinical practice and motivate future studies on fMRI analysis.

Xiaodong Wang, Junbao Zhuo, Shuhao Cui et al.

Semi-supervised domain adaptation (SSDA) aims to solve tasks in target domain by utilizing transferable information learned from the available source domain and a few labeled target data. However, source data is not always accessible in practical scenarios, which restricts the application of SSDA in real world circumstances. In this paper, we propose a novel task named Semi-supervised Source Hypothesis Transfer (SSHT), which performs domain adaptation based on source trained model, to generalize well in target domain with a few supervisions. In SSHT, we are facing two challenges: (1) The insufficient labeled target data may result in target features near the decision boundary, with the increased risk of mis-classification; (2) The data are usually imbalanced in source domain, so the model trained with these data is biased. The biased model is prone to categorize samples of minority categories into majority ones, resulting in low prediction diversity. To tackle the above issues, we propose Consistency and Diversity Learning (CDL), a simple but effective framework for SSHT by facilitating prediction consistency between two randomly augmented unlabeled data and maintaining the prediction diversity when adapting model to target domain. Encouraging consistency regularization brings difficulty to memorize the few labeled target data and thus enhances the generalization ability of the learned model. We further integrate Batch Nuclear-norm Maximization into our method to enhance the discriminability and diversity. Experimental results show that our method outperforms existing SSDA methods and unsupervised model adaptation methods on DomainNet, Office-Home and Office-31 datasets. The code is available at https://github.com/Wang-xd1899/SSHT.