Hua Han

Chang Shu, Xi Chen, Qiwei Xie et al.

In this paper, we propose a novel non-iterative algorithm to simultaneously estimate optimal rigid transformation for serial section images, which is a key component in volume reconstruction of serial sections of biological tissue. In order to avoid error accumulation and propagation caused by current algorithms, we add extra condition that the position of the first and the last section images should remain unchanged. This constrained simultaneous registration problem has not been solved before. Our algorithm method is non-iterative, it can simultaneously compute rigid transformation for a large number of serial section images in a short time. We prove that our algorithm gets optimal solution under ideal condition. And we test our algorithm with synthetic data and real data to verify our algorithm's effectiveness.

Zejin Wang, Guoqing Li, Xi Chen et al.

The continuity of biological tissue between consecutive biomedical images makes it possible for the video interpolation algorithm, to recover large area defects and tears that are common in biomedical images. However, noise and blur differences, large deformation, and drift between biomedical images, make the task challenging. To address the problem, this paper introduces a deformation-aware network to synthesize each pixel in accordance with the continuity of biological tissue. First, we develop a deformation-aware layer for consecutive biomedical images interpolation that implicitly adopting global perceptual deformation. Second, we present an adaptive style-balance loss to take the style differences of consecutive biomedical images such as blur and noise into consideration. Guided by the deformation-aware module, we synthesize each pixel from a global domain adaptively which further improves the performance of pixel synthesis. Quantitative and qualitative experiments on the benchmark dataset show that the proposed method is superior to the state-of-the-art approaches.

Chang Shu, Xi Chen, Qiwei Xie et al.

Computer vision researchers have been expecting that neural networks have spatial transformation ability to eliminate the interference caused by geometric distortion for a long time. Emergence of spatial transformer network makes dream come true. Spatial transformer network and its variants can handle global displacement well, but lack the ability to deal with local spatial variance. Hence how to achieve a better manner of deformation in the neural network has become a pressing matter of the moment. To address this issue, we analyze the advantages and disadvantages of approximation theory and optical flow theory, then we combine them to propose a novel way to achieve image deformation and implement it with a hierarchical convolutional neural network. This new approach solves for a linear deformation along with an optical flow field to model image deformation. In the experiments of cluttered MNIST handwritten digits classification and image plane alignment, our method outperforms baseline methods by a large margin.