Shuo Wang

Mengyun Qiao, Shuo Wang, Huaqi Qiu et al.

Two key questions in cardiac image analysis are to assess the anatomy and motion of the heart from images; and to understand how they are associated with non-imaging clinical factors such as gender, age and diseases. While the first question can often be addressed by image segmentation and motion tracking algorithms, our capability to model and to answer the second question is still limited. In this work, we propose a novel conditional generative model to describe the 4D spatio-temporal anatomy of the heart and its interaction with non-imaging clinical factors. The clinical factors are integrated as the conditions of the generative modelling, which allows us to investigate how these factors influence the cardiac anatomy. We evaluate the model performance in mainly two tasks, anatomical sequence completion and sequence generation. The model achieves a high performance in anatomical sequence completion, comparable to or outperforming other state-of-the-art generative models. In terms of sequence generation, given clinical conditions, the model can generate realistic synthetic 4D sequential anatomies that share similar distributions with the real data.

Ouxiang Li, Yanbin Hao, Zhicai Wang et al.

Model inversion attacks (MIAs) aim to reconstruct private images from a target classifier's training set, thereby raising privacy concerns in AI applications. Previous GAN-based MIAs tend to suffer from inferior generative fidelity due to GAN's inherent flaws and biased optimization within latent space. To alleviate these issues, leveraging on diffusion models' remarkable synthesis capabilities, we propose Diffusion-based Model Inversion (Diff-MI) attacks. Specifically, we introduce a novel target-specific conditional diffusion model (CDM) to purposely approximate target classifier's private distribution and achieve superior accuracy-fidelity balance. Our method involves a two-step learning paradigm. Step-1 incorporates the target classifier into the entire CDM learning under a pretrain-then-finetune fashion, with creating pseudo-labels as model conditions in pretraining and adjusting specified layers with image predictions in fine-tuning. Step-2 presents an iterative image reconstruction method, further enhancing the attack performance through a combination of diffusion priors and target knowledge. Additionally, we propose an improved max-margin loss that replaces the hard max with top-k maxes, fully leveraging feature information and soft labels from the target classifier. Extensive experiments demonstrate that Diff-MI significantly improves generative fidelity with an average decrease of 20\% in FID while maintaining competitive attack accuracy compared to state-of-the-art methods across various datasets and models. Our code is available at: \url{https://github.com/Ouxiang-Li/Diff-MI}.

Yizhe Zhang, Tao Zhou, Shuo Wang et al.

The Segment Anything Model (SAM) exhibits a capability to segment a wide array of objects in natural images, serving as a versatile perceptual tool for various downstream image segmentation tasks. In contrast, medical image segmentation tasks often rely on domain-specific knowledge (DSK). In this paper, we propose a novel method that combines the segmentation foundation model (i.e., SAM) with domain-specific knowledge for reliable utilization of unlabeled images in building a medical image segmentation model. Our new method is iterative and consists of two main stages: (1) segmentation model training; (2) expanding the labeled set by using the trained segmentation model, an unlabeled set, SAM, and domain-specific knowledge. These two stages are repeated until no more samples are added to the labeled set. A novel optimal-matching-based method is developed for combining the SAM-generated segmentation proposals and pixel-level and image-level DSK for constructing annotations of unlabeled images in the iterative stage (2). In experiments, we demonstrate the effectiveness of our proposed method for breast cancer segmentation in ultrasound images, polyp segmentation in endoscopic images, and skin lesion segmentation in dermoscopic images. Our work initiates a new direction of semi-supervised learning for medical image segmentation: the segmentation foundation model can be harnessed as a valuable tool for label-efficient segmentation learning in medical image segmentation.

Mengyun Qiao, Kathryn A McGurk, Shuo Wang et al.

Understanding the structure and motion of the heart is crucial for diagnosing and managing cardiovascular diseases, the leading cause of global death. There is wide variation in cardiac shape and motion patterns, influenced by demographic, anthropometric and disease factors. Unravelling normal patterns of shape and motion, and understanding how each individual deviates from the norm, would facilitate accurate diagnosis and personalised treatment strategies. To this end, we developed a conditional generative model, MeshHeart, to learn the distribution of shape and motion patterns for the left and right ventricles of the heart. To model the high-dimensional spatio-temporal mesh data, MeshHeart employs a geometric encoder to represent cardiac meshes in a latent space, and a temporal Transformer to model the motion dynamics of latent representations. Based on MeshHeart, we investigate the latent space of 3D+t cardiac mesh sequences and propose a distance metric, latent delta, which quantifies the deviation of a real heart from its personalised normative pattern. In experiments using a large cardiac magnetic resonance image dataset of 38,309 subjects from the UK Biobank, MeshHeart demonstrates high performance in cardiac mesh sequence reconstruction and generation. Latent space features are discriminative for cardiac disease classification, whereas latent delta exhibits strong correlations with clinical phenotypes in phenome-wide association studies. The code and the trained model are released to support further research.

Zhiwei Yang, Kexue Fu, Minghong Duan et al.

Weakly supervised semantic segmentation (WSSS) with image-level labels aims to achieve segmentation tasks without dense annotations. However, attributed to the frequent coupling of co-occurring objects and the limited supervision from image-level labels, the challenging co-occurrence problem is widely present and leads to false activation of objects in WSSS. In this work, we devise a 'Separate and Conquer' scheme SeCo to tackle this issue from dimensions of image space and feature space. In the image space, we propose to 'separate' the co-occurring objects with image decomposition by subdividing images into patches. Importantly, we assign each patch a category tag from Class Activation Maps (CAMs), which spatially helps remove the co-context bias and guide the subsequent representation. In the feature space, we propose to 'conquer' the false activation by enhancing semantic representation with multi-granularity knowledge contrast. To this end, a dual-teacher-single-student architecture is designed and tag-guided contrast is conducted, which guarantee the correctness of knowledge and further facilitate the discrepancy among co-contexts. We streamline the multi-staged WSSS pipeline end-to-end and tackle this issue without external supervision. Extensive experiments are conducted, validating the efficiency of our method and the superiority over previous single-staged and even multi-staged competitors on PASCAL VOC and MS COCO. Code is available at https://github.com/zwyang6/SeCo.git.

Xi Chen, Shuo Wang

The rapid development of large language models (LLMs) gives rise to ethical concerns about their performance, while opening new avenues for developing toxic language detection techniques. However, LLMs' unethical output and their capability of detecting toxicity have primarily been tested on language data that do not demand complex meaning inference, such as the biased associations of 'he' with programmer and 'she' with household. Nowadays toxic language adopts a much more creative range of implicit forms, thanks to advanced censorship. In this study, we collect authentic toxic interactions that evade online censorship and that are verified by human annotators as inference-intensive. To evaluate and improve LLMs' reasoning of the authentic implicit toxic language, we propose a new prompting method, Pragmatic Inference Chain (PIC), drawn on interdisciplinary findings from cognitive science and linguistics. The PIC prompting significantly improves the success rate of GPT-4o, Llama-3.1-70B-Instruct, DeepSeek-v2.5, and DeepSeek-v3 in identifying implicit toxic language, compared to five baseline prompts, such as CoT and rule-based baselines. In addition, it also facilitates the models to produce more explicit and coherent reasoning processes, hence can potentially be generalized to other inference-intensive tasks, e.g., understanding humour and metaphors.

Zhiwei Yang, Yucong Meng, Kexue Fu et al.

Weakly supervised semantic segmentation (WSSS) with image-level labels intends to achieve dense tasks without laborious annotations. However, due to the ambiguous contexts and fuzzy regions, the performance of WSSS, especially the stages of generating Class Activation Maps (CAMs) and refining pseudo masks, widely suffers from ambiguity while being barely noticed by previous literature. In this work, we propose UniA, a unified single-staged WSSS framework, to efficiently tackle this issue from the perspective of uncertainty inference and affinity diversification, respectively. When activating class objects, we argue that the false activation stems from the bias to the ambiguous regions during the feature extraction. Therefore, we design a more robust feature representation with a probabilistic Gaussian distribution and introduce the uncertainty estimation to avoid the bias. A distribution loss is particularly proposed to supervise the process, which effectively captures the ambiguity and models the complex dependencies among features. When refining pseudo labels, we observe that the affinity from the prevailing refinement methods intends to be similar among ambiguities. To this end, an affinity diversification module is proposed to promote diversity among semantics. A mutual complementing refinement is proposed to initially rectify the ambiguous affinity with multiple inferred pseudo labels. More importantly, a contrastive affinity loss is further designed to diversify the relations among unrelated semantics, which reliably propagates the diversity into the whole feature representations and helps generate better pseudo masks. Extensive experiments are conducted on PASCAL VOC, MS COCO, and medical ACDC datasets, which validate the efficiency of UniA tackling ambiguity and the superiority over recent single-staged or even most multi-staged competitors.

Yizhe Zhang, Shuo Wang, Tao Zhou et al.

Segmentation quality assessment (SQA) plays a critical role in the deployment of a medical image based AI system. Users need to be informed/alerted whenever an AI system generates unreliable/incorrect predictions. With the introduction of the Segment Anything Model (SAM), a general foundation segmentation model, new research opportunities emerged in how one can utilize SAM for medical image segmentation. In this paper, we propose a novel SQA method, called SQA-SAM, which exploits SAM to enhance the accuracy of quality assessment for medical image segmentation. When a medical image segmentation model (MedSeg) produces predictions for a test image, we generate visual prompts based on the predictions, and SAM is utilized to generate segmentation maps corresponding to the visual prompts. How well MedSeg's segmentation aligns with SAM's segmentation indicates how well MedSeg's segmentation aligns with the general perception of objectness and image region partition. We develop a score measure for such alignment. In experiments, we find that the generated scores exhibit moderate to strong positive correlation (in Pearson correlation and Spearman correlation) with Dice coefficient scores reflecting the true segmentation quality.

Kang Wang, Chen Qin, Zhang Shi et al.

Deep learning models have achieved state-of-the-art performance in automated Cardiac Magnetic Resonance (CMR) analysis. However, the efficacy of these models is highly dependent on the availability of high-quality, artifact-free images. In clinical practice, CMR acquisitions are frequently degraded by respiratory motion, yet the robustness of deep learning models against such artifacts remains an underexplored problem. To promote research in this domain, we organized the MICCAI CMRxMotion challenge. We curated and publicly released a dataset of 320 CMR cine series from 40 healthy volunteers who performed specific breathing protocols to induce a controlled spectrum of motion artifacts. The challenge comprised two tasks: 1) automated image quality assessment to classify images based on motion severity, and 2) robust myocardial segmentation in the presence of motion artifacts. A total of 22 algorithms were submitted and evaluated on the two designated tasks. This paper presents a comprehensive overview of the challenge design and dataset, reports the evaluation results for the top-performing methods, and further investigates the impact of motion artifacts on five clinically relevant biomarkers. All resources and code are publicly available at: https://github.com/CMRxMotion

Yuhan Wu, Tiantian Wei, Shuo Wang et al.

Interactive articulated manipulation requires long-horizon, multi-step interactions with appliances while maintaining physical consistency. Existing vision-language and diffusion-based policies struggle to generalize across parts, instances, and categories. We first introduce ArtiBench, a five-level benchmark covering kitchen, storage, office, and tool environments. ArtiBench enables structured evaluation from cross-part and cross-instance variation to long-horizon multi-object tasks, revealing the core generalization challenges of articulated object manipulation. Building on this benchmark, we propose ArtiBrain, a modular framework that unifies high-level reasoning with adaptive low-level control. ArtiBrain uses a VLM-based Task Reasoner (GPT-4.1) to decompose and validate subgoals, and employs a Hybrid Controller that combines geometry-aware keyframe execution with affordance-guided diffusion for precise and interpretable manipulation. An Affordance Memory Bank continually accumulates successful execution episodes and propagates part-level actionable affordances to unseen articulated parts and configurations. Extensive experiments on ArtiBench show that our ArtiBrain significantly outperforms state-of-the-art multimodal and diffusion-based methods in robustness and generalization. Code and dataset will be released upon acceptance.

Fangyuan Mao, Shuo Wang, Jilin Mei et al.

Joint RGB-infrared perception is essential for achieving robustness under diverse weather and illumination conditions. Although foundation models excel within single modalities, they suffer from substantial cross-modal degradation, an issue we attribute to a pattern shortcut, i.e., a modal bias that prioritizes superficial sensor patterns over underlying semantics. To address this problem, we introduce UNIV, a Unified foundation model for Infrared and Visible modalities. At the core of UNIV lies Patch Cross-modal Contrastive Learning (PCCL), a self-supervised contrastive learning strategy that constructs a unified cross-modal feature space. PCCL employs a frozen pre-trained model to sample pseudo patch pairs based on semantic similarity, and aligns infrared-visible representations by attracting semantically related pairs while repelling unrelated ones. This process simultaneously enhances cross-modal alignment and inter-class semantic separability, guiding the model to focus on semantic structure rather than falling into pattern shortcuts. To further enable cross-modal learning, we introduce MVIP, the most comprehensive visible-infrared benchmark to date, containing 98,992 precisely aligned image pairs across diverse scenes. Extensive experiments demonstrate UNIV's superior performance on infrared tasks (+1.7 mIoU for semantic segmentation and +0.7 mAP for detection), while maintaining competitive accuracy on RGB tasks.

Jialei Huang, Shuo Wang, Fanqi Lin et al.

Vision-Language-Action (VLA) models have shown remarkable achievements, driven by the rich implicit knowledge of their vision-language components. However, achieving generalist robotic agents demands precise grounding into physical interactions, especially in contact-rich scenarios where fine-grained force control is essential. We advance VLAs' implicit knowledge beyond identifying what to do, towards guiding how to physically interact with real world. This paper introduces Tactile-VLA, a novel framework that deeply fuses vision, language, action, and tactile sensing. This framework incorporates a hybrid position-force controller to translate the model's intentions into precise physical actions and a reasoning module that allows the robot to adapt its strategy based on tactile feedback. Experiments demonstrate Tactile-VLA's effectiveness and generalizability in three key aspects: (1) enabling tactile-aware instruction following, (2) utilizing tactile-relevant commonsense, and (3) facilitating adaptive tactile-involved reasoning. A key finding is that the VLM's prior knowledge already contains semantic understanding of physical interaction; by connecting it to the robot's tactile sensors with only a few demonstrations, we can activate this prior knowledge to achieve zero-shot generalization in contact-rich tasks.

Yili He, Yan Zhu, Peiyao Fu et al.

Pre-training on image-text colonoscopy records offers substantial potential for improving endoscopic image analysis, but faces challenges including non-informative background images, complex medical terminology, and ambiguous multi-lesion descriptions. We introduce Endo-CLIP, a novel self-supervised framework that enhances Contrastive Language-Image Pre-training (CLIP) for this domain. Endo-CLIP's three-stage framework--cleansing, attunement, and unification--addresses these challenges by (1) removing background frames, (2) leveraging large language models to extract clinical attributes for fine-grained contrastive learning, and (3) employing patient-level cross-attention to resolve multi-polyp ambiguities. Extensive experiments demonstrate that Endo-CLIP significantly outperforms state-of-the-art pre-training methods in zero-shot and few-shot polyp detection and classification, paving the way for more accurate and clinically relevant endoscopic analysis.

Zi Wang, Fanwen Wang, Chen Qin et al.

Cardiac magnetic resonance imaging (MRI) has emerged as a clinically gold-standard technique for diagnosing cardiac diseases, thanks to its ability to provide diverse information with multiple modalities and anatomical views. Accelerated cardiac MRI is highly expected to achieve time-efficient and patient-friendly imaging, and then advanced image reconstruction approaches are required to recover high-quality, clinically interpretable images from undersampled measurements. However, the lack of publicly available cardiac MRI k-space dataset in terms of both quantity and diversity has severely hindered substantial technological progress, particularly for data-driven artificial intelligence. Here, we provide a standardized, diverse, and high-quality CMRxRecon2024 dataset to facilitate the technical development, fair evaluation, and clinical transfer of cardiac MRI reconstruction approaches, towards promoting the universal frameworks that enable fast and robust reconstructions across different cardiac MRI protocols in clinical practice. To the best of our knowledge, the CMRxRecon2024 dataset is the largest and most protocal-diverse publicly available cardiac k-space dataset. It is acquired from 330 healthy volunteers, covering commonly used modalities, anatomical views, and acquisition trajectories in clinical cardiac MRI workflows. Besides, an open platform with tutorials, benchmarks, and data processing tools is provided to facilitate data usage, advanced method development, and fair performance evaluation.

Qin Li, Yizhe Zhang, Yan Li et al.

The segmentation foundation model, e.g., Segment Anything Model (SAM), has attracted increasing interest in the medical image community. Early pioneering studies primarily concentrated on assessing and improving SAM's performance from the perspectives of overall accuracy and efficiency, yet little attention was given to the fairness considerations. This oversight raises questions about the potential for performance biases that could mirror those found in task-specific deep learning models like nnU-Net. In this paper, we explored the fairness dilemma concerning large segmentation foundation models. We prospectively curate a benchmark dataset of 3D MRI and CT scans of the organs including liver, kidney, spleen, lung and aorta from a total of 1056 healthy subjects with expert segmentations. Crucially, we document demographic details such as gender, age, and body mass index (BMI) for each subject to facilitate a nuanced fairness analysis. We test state-of-the-art foundation models for medical image segmentation, including the original SAM, medical SAM and SAT models, to evaluate segmentation efficacy across different demographic groups and identify disparities. Our comprehensive analysis, which accounts for various confounding factors, reveals significant fairness concerns within these foundational models. Moreover, our findings highlight not only disparities in overall segmentation metrics, such as the Dice Similarity Coefficient but also significant variations in the spatial distribution of segmentation errors, offering empirical evidence of the nuanced challenges in ensuring fairness in medical image segmentation.

Tianyu Huang, Tao Zhou, Weidi Xie et al.

The current variants of the Segment Anything Model (SAM), which include the original SAM and Medical SAM, still lack the capability to produce sufficiently accurate segmentation for medical images. In medical imaging contexts, it is not uncommon for human experts to rectify segmentations of specific test samples after SAM generates its segmentation predictions. These rectifications typically entail manual or semi-manual corrections employing state-of-the-art annotation tools. Motivated by this process, we introduce a novel approach that leverages the advantages of online machine learning to enhance Segment Anything (SA) during test time. We employ rectified annotations to perform online learning, with the aim of improving the segmentation quality of SA on medical images. To improve the effectiveness and efficiency of online learning when integrated with large-scale vision models like SAM, we propose a new method called Auxiliary Online Learning (AuxOL). AuxOL creates and applies a small auxiliary model (specialist) in conjunction with SAM (generalist), entails adaptive online-batch and adaptive segmentation fusion. Experiments conducted on eight datasets covering four medical imaging modalities validate the effectiveness of the proposed method. Our work proposes and validates a new, practical, and effective approach for enhancing SA on downstream segmentation tasks (e.g., medical image segmentation).

Shuo Wang, Chen Qin, Nicolo Savioli et al.

In cardiac magnetic resonance (CMR) imaging, a 3D high-resolution segmentation of the heart is essential for detailed description of its anatomical structures. However, due to the limit of acquisition duration and respiratory/cardiac motion, stacks of multi-slice 2D images are acquired in clinical routine. The segmentation of these images provides a low-resolution representation of cardiac anatomy, which may contain artefacts caused by motion. Here we propose a novel latent optimisation framework that jointly performs motion correction and super resolution for cardiac image segmentations. Given a low-resolution segmentation as input, the framework accounts for inter-slice motion in cardiac MR imaging and super-resolves the input into a high-resolution segmentation consistent with input. A multi-view loss is incorporated to leverage information from both short-axis view and long-axis view of cardiac imaging. To solve the inverse problem, iterative optimisation is performed in a latent space, which ensures the anatomical plausibility. This alleviates the need of paired low-resolution and high-resolution images for supervised learning. Experiments on two cardiac MR datasets show that the proposed framework achieves high performance, comparable to state-of-the-art super-resolution approaches and with better cross-domain generalisability and anatomical plausibility.

Chen Chen, Chen Qin, Huaqi Qiu et al.

Neural network-based approaches can achieve high accuracy in various medical image segmentation tasks. However, they generally require large labelled datasets for supervised learning. Acquiring and manually labelling a large medical dataset is expensive and sometimes impractical due to data sharing and privacy issues. In this work, we propose an adversarial data augmentation method for training neural networks for medical image segmentation. Instead of generating pixel-wise adversarial attacks, our model generates plausible and realistic signal corruptions, which models the intensity inhomogeneities caused by a common type of artefacts in MR imaging: bias field. The proposed method does not rely on generative networks, and can be used as a plug-in module for general segmentation networks in both supervised and semi-supervised learning. Using cardiac MR imaging we show that such an approach can improve the generalization ability and robustness of models as well as provide significant improvements in low-data scenarios.

Chen Qin, Shuo Wang, Chen Chen et al.

Image registration is an ill-posed inverse problem which often requires regularisation on the solution space. In contrast to most of the current approaches which impose explicit regularisation terms such as smoothness, in this paper we propose a novel method that can implicitly learn biomechanics-informed regularisation. Such an approach can incorporate application-specific prior knowledge into deep learning based registration. Particularly, the proposed biomechanics-informed regularisation leverages a variational autoencoder (VAE) to learn a manifold for biomechanically plausible deformations and to implicitly capture their underlying properties via reconstructing biomechanical simulations. The learnt VAE regulariser then can be coupled with any deep learning based registration network to regularise the solution space to be biomechanically plausible. The proposed method is validated in the context of myocardial motion tracking on 2D stacks of cardiac MRI data from two different datasets. The results show that it can achieve better performance against other competing methods in terms of motion tracking accuracy and has the ability to learn biomechanical properties such as incompressibility and strains. The method has also been shown to have better generalisability to unseen domains compared with commonly used L2 regularisation schemes.

Philip Nadler, Shuo Wang, Rossella Arcucci et al.

The global pandemic of the 2019-nCov requires the evaluation of policy interventions to mitigate future social and economic costs of quarantine measures worldwide. We propose an epidemiological model for forecasting and policy evaluation which incorporates new data in real-time through variational data assimilation. We analyze and discuss infection rates in China, the US and Italy. In particular, we develop a custom compartmental SIR model fit to variables related to the epidemic in Chinese cities, named SITR model. We compare and discuss model results which conducts updates as new observations become available. A hybrid data assimilation approach is applied to make results robust to initial conditions. We use the model to do inference on infection numbers as well as parameters such as the disease transmissibility rate or the rate of recovery. The parameterisation of the model is parsimonious and extendable, allowing for the incorporation of additional data and parameters of interest. This allows for scalability and the extension of the model to other locations or the adaption of novel data sources.

Xiaobo Wang, Shifeng Zhang, Shuo Wang et al.

Face recognition has witnessed significant progress due to the advances of deep convolutional neural networks (CNNs), the central task of which is how to improve the feature discrimination. To this end, several margin-based (\textit{e.g.}, angular, additive and additive angular margins) softmax loss functions have been proposed to increase the feature margin between different classes. However, despite great achievements have been made, they mainly suffer from three issues: 1) Obviously, they ignore the importance of informative features mining for discriminative learning; 2) They encourage the feature margin only from the ground truth class, without realizing the discriminability from other non-ground truth classes; 3) The feature margin between different classes is set to be same and fixed, which may not adapt the situations very well. To cope with these issues, this paper develops a novel loss function, which adaptively emphasizes the mis-classified feature vectors to guide the discriminative feature learning. Thus we can address all the above issues and achieve more discriminative face features. To the best of our knowledge, this is the first attempt to inherit the advantages of feature margin and feature mining into a unified loss function. Experimental results on several benchmarks have demonstrated the effectiveness of our method over state-of-the-art alternatives.