Zhong Su

Yuhang Kang, Ziyu Su, Tianyang Wang et al.

Compared to hematoxylin-eosin (H&E) staining, immunohistochemistry (IHC) not only maintains the structural features of tissue samples, but also provides high-resolution protein localization, which is essential for aiding in pathology diagnosis. Despite its diagnostic value, IHC remains a costly and labor-intensive technique. Its limited scalability and constraints in multiplexing further hinder widespread adoption, especially in resource-limited settings. Consequently, researchers are increasingly exploring computational stain translation techniques to synthesize IHC-equivalent images from H&E-stained slides, aiming to extract protein-level information more efficiently and cost-effectively. However, most existing stain translation techniques rely on a linearly weighted summation of multiple loss terms within a single objective function, strategy that often overlooks the interdepedence among these components-resulting in suboptimal image quality and an inability to simultaneously preserve structural authenticity and color fidelity. To address this limitation, we propose a novel network architecture that follows a progressive structure, incorporating color and cell border generation logic, which enables each visual aspect to be optimized in a stage-wise and decoupled manner. To validate the effectiveness of our proposed network architecture, we build upon the Adaptive Supervised PatchNCE (ASP) framework as our baseline. We introduce additional loss functions based on 3,3'-diaminobenzidine (DAB) chromogen concentration and image gradient, enhancing color fidelity and cell boundary clarity in the generated IHC images. By reconstructing the generation pipeline using our structure-color-cell boundary progressive mechanism, experiments on HER2 and ER datasets demonstrated that the model significantly improved visual quality and achieved finer structural details.

Ziyu Su, Abdul Rehman Akbar, Usama Sajjad et al.

Foundation models (FM) have transformed computational pathology but remain computationally prohibitive for clinical deployment due to their massive parameter counts and high-magnification processing requirements. Here, we introduce XMAG, a lightweight FM developed through corss-magnification distillation that transfers knowledge from state-of-the-art 20x magnification teacher to an efficient 5x magnification student architecture. XMAG employs a compact backbone and operates entirely at 5x, requiring 11.3 times fewer patches per whole slide image (WSI) compared to existing approaches. Our Novel distillation framework incorporates dual-level knowledge transfer, aligning both global image representations and local spatial token mapping. We trained XMAG on 3.49 million images curated from publicly available datasets and evaluated performance across six clinically relevant histopathology analysis tasks spanning multiple cancer types. XMAG achieved diagnostic accuracy within 1% of substantially larger foundation models while delivering 30-fold processing acceleration, reaching 8.8 WSIs per minute processing speed. Our cross-institutional validation confirmed robust generalization. Further, we developed an end-to-end training strategy to further boost our model's performance to approach the larger FMs' performance. These results establish cross-magnification distillation as a viable approach for deploying FM capabilities in resource-constrained clinical environments, potentially enabling real-time pathology AI integration.

Mengting Hu, Honglei Guo, Shiwan Zhao et al.

A mind-map is a diagram that represents the central concept and key ideas in a hierarchical way. Converting plain text into a mind-map will reveal its key semantic structure and be easier to understand. Given a document, the existing automatic mind-map generation method extracts the relationships of every sentence pair to generate the directed semantic graph for this document. The computation complexity increases exponentially with the length of the document. Moreover, it is difficult to capture the overall semantics. To deal with the above challenges, we propose an efficient mind-map generation network that converts a document into a graph via sequence-to-graph. To guarantee a meaningful mind-map, we design a graph refinement module to adjust the relation graph in a reinforcement learning manner. Extensive experimental results demonstrate that the proposed approach is more effective and efficient than the existing methods. The inference time is reduced by thousands of times compared with the existing methods. The case studies verify that the generated mind-maps better reveal the underlying semantic structures of the document.

Mengting Hu, Shiwan Zhao, Honglei Guo et al.

Aspect category detection (ACD) in sentiment analysis aims to identify the aspect categories mentioned in a sentence. In this paper, we formulate ACD in the few-shot learning scenario. However, existing few-shot learning approaches mainly focus on single-label predictions. These methods can not work well for the ACD task since a sentence may contain multiple aspect categories. Therefore, we propose a multi-label few-shot learning method based on the prototypical network. To alleviate the noise, we design two effective attention mechanisms. The support-set attention aims to extract better prototypes by removing irrelevant aspects. The query-set attention computes multiple prototype-specific representations for each query instance, which are then used to compute accurate distances with the corresponding prototypes. To achieve multi-label inference, we further learn a dynamic threshold per instance by a policy network. Extensive experimental results on three datasets demonstrate that the proposed method significantly outperforms strong baselines.

Mengting Hu, Shiwan Zhao, Honglei Guo et al.

Aspect-based sentiment analysis (ABSA) is to predict the sentiment polarity towards a particular aspect in a sentence. Recently, this task has been widely addressed by the neural attention mechanism, which computes attention weights to softly select words for generating aspect-specific sentence representations. The attention is expected to concentrate on opinion words for accurate sentiment prediction. However, attention is prone to be distracted by noisy or misleading words, or opinion words from other aspects. In this paper, we propose an alternative hard-selection approach, which determines the start and end positions of the opinion snippet, and selects the words between these two positions for sentiment prediction. Specifically, we learn deep associations between the sentence and aspect, and the long-term dependencies within the sentence by leveraging the pre-trained BERT model. We further detect the opinion snippet by self-critical reinforcement learning. Especially, experimental results demonstrate the effectiveness of our method and prove that our hard-selection approach outperforms soft-selection approaches when handling multi-aspect sentences.

Mengting Hu, Yike Wu, Shiwan Zhao et al.

Cross-domain sentiment classification has drawn much attention in recent years. Most existing approaches focus on learning domain-invariant representations in both the source and target domains, while few of them pay attention to the domain-specific information. Despite the non-transferability of the domain-specific information, simultaneously learning domain-dependent representations can facilitate the learning of domain-invariant representations. In this paper, we focus on aspect-level cross-domain sentiment classification, and propose to distill the domain-invariant sentiment features with the help of an orthogonal domain-dependent task, i.e. aspect detection, which is built on the aspects varying widely in different domains. We conduct extensive experiments on three public datasets and the experimental results demonstrate the effectiveness of our method.

Yike Wu, Shiwan Zhao, Jia Chen et al.

Improving the captioning performance on low-resource languages by leveraging English caption datasets has received increasing research interest in recent years. Existing works mainly fall into two categories: translation-based and alignment-based approaches. In this paper, we propose to combine the merits of both approaches in one unified architecture. Specifically, we use a pre-trained English caption model to generate high-quality English captions, and then take both the image and generated English captions to generate low-resource language captions. We improve the captioning performance by adding the cycle consistency constraint on the cycle of image regions, English words, and low-resource language words. Moreover, our architecture has a flexible design which enables it to benefit from large monolingual English caption datasets. Experimental results demonstrate that our approach outperforms the state-of-the-art methods on common evaluation metrics. The attention visualization also shows that the proposed approach really improves the fine-grained alignment between words and image regions.

Bingzhe Wu, Shiwan Zhao, Guangyu Sun et al.

Recently, deep convolutional neural networks (CNNs) have achieved great success in pathological image classification. However, due to the limited number of labeled pathological images, there are still two challenges to be addressed: (1) overfitting: the performance of a CNN model is undermined by the overfitting due to its huge amounts of parameters and the insufficiency of labeled training data. (2) privacy leakage: the model trained using a conventional method may involuntarily reveal the private information of the patients in the training dataset. The smaller the dataset, the worse the privacy leakage. To tackle the above two challenges, we introduce a novel stochastic gradient descent (SGD) scheme, named patient privacy preserving SGD (P3SGD), which performs the model update of the SGD in the patient level via a large-step update built upon each patient's data. Specifically, to protect privacy and regularize the CNN model, we propose to inject the well-designed noise into the updates. Moreover, we equip our P3SGD with an elaborated strategy to adaptively control the scale of the injected noise. To validate the effectiveness of P3SGD, we perform extensive experiments on a real-world clinical dataset and quantitatively demonstrate the superior ability of P3SGD in reducing the risk of overfitting. We also provide a rigorous analysis of the privacy cost under differential privacy. Additionally, we find that the models trained with P3SGD are resistant to the model-inversion attack compared with those trained using non-private SGD.

Mengting Hu, Shiwan Zhao, Li Zhang et al.

Aspect level sentiment classification is a fine-grained sentiment analysis task. To detect the sentiment towards a particular aspect in a sentence, previous studies have developed various attention-based methods for generating aspect-specific sentence representations. However, the attention may inherently introduce noise and downgrade the performance. In this paper, we propose constrained attention networks (CAN), a simple yet effective solution, to regularize the attention for multi-aspect sentiment analysis, which alleviates the drawback of the attention mechanism. Specifically, we introduce orthogonal regularization on multiple aspects and sparse regularization on each single aspect. Experimental results on two public datasets demonstrate the effectiveness of our approach. We further extend our approach to multi-task settings and outperform the state-of-the-art methods.