Bo Li

Xianjing Liu, Bo Li, Meike W. Vernooij et al.

This study addresses the challenges of confounding effects and interpretability in artificial-intelligence-based medical image analysis. Whereas existing literature often resolves confounding by removing confounder-related information from latent representations, this strategy risks affecting image reconstruction quality in generative models, thus limiting their applicability in feature visualization. To tackle this, we propose a different strategy that retains confounder-related information in latent representations while finding an alternative confounder-free representation of the image data. Our approach views the latent space of an autoencoder as a vector space, where imaging-related variables, such as the learning target (t) and confounder (c), have a vector capturing their variability. The confounding problem is addressed by searching a confounder-free vector which is orthogonal to the confounder-related vector but maximally collinear to the target-related vector. To achieve this, we introduce a novel correlation-based loss that not only performs vector searching in the latent space, but also encourages the encoder to generate latent representations linearly correlated with the variables. Subsequently, we interpret the confounder-free representation by sampling and reconstructing images along the confounder-free vector. The efficacy and flexibility of our proposed method are demonstrated across three applications, accommodating multiple confounders and utilizing diverse image modalities. Results affirm the method's effectiveness in reducing confounder influences, preventing wrong or misleading associations, and offering a unique visual interpretation for in-depth investigations by clinical and epidemiological researchers. The code is released in the following GitLab repository: https://gitlab.com/radiology/compopbio/ai_based_association_analysis}

Xuan Li, Yun Wang, Bo Li

Tabular neural network (NN) has attracted remarkable attentions and its recent advances have gradually narrowed the performance gap with respect to tree-based models on many public datasets. While the mainstreams focus on calibrating NN to fit tabular data, we emphasize the importance of homogeneous embeddings and alternately concentrate on regularizing tabular inputs through supervised pretraining. Specifically, we extend a recent work (DeepTLF) and utilize the structure of pretrained tree ensembles to transform raw variables into a single vector (T2V), or an array of tokens (T2T). Without loss of space efficiency, these binarized embeddings can be consumed by canonical tabular NN with fully-connected or attention-based building blocks. Through quantitative experiments on 88 OpenML datasets with binary classification task, we validated that the proposed tree-regularized representation not only tapers the difference with respect to tree-based models, but also achieves on-par and better performance when compared with advanced NN models. Most importantly, it possesses better robustness and can be easily scaled and generalized as standalone encoder for tabular modality. Codes: https://github.com/milanlx/tree-regularized-embedding.

Runhua Xu, Bo Li, Chao Li et al.

Federated learning is a computing paradigm that enhances privacy by enabling multiple parties to collaboratively train a machine learning model without revealing personal data. However, current research indicates that traditional federated learning platforms are unable to ensure privacy due to privacy leaks caused by the interchange of gradients. To achieve privacy-preserving federated learning, integrating secure aggregation mechanisms is essential. Unfortunately, existing solutions are vulnerable to recently demonstrated inference attacks such as the disaggregation attack. This paper proposes TAPFed, an approach for achieving privacy-preserving federated learning in the context of multiple decentralized aggregators with malicious actors. TAPFed uses a proposed threshold functional encryption scheme and allows for a certain number of malicious aggregators while maintaining security and privacy. We provide formal security and privacy analyses of TAPFed and compare it to various baselines through experimental evaluation. Our results show that TAPFed offers equivalent performance in terms of model quality compared to state-of-the-art approaches while reducing transmission overhead by 29%-45% across different model training scenarios. Most importantly, TAPFed can defend against recently demonstrated inference attacks caused by curious aggregators, which the majority of existing approaches are susceptible to.

Xiaoyang Wang, Bo Li, Yibo Zhang et al.

Several AutoML approaches have been proposed to automate the machine learning (ML) process, such as searching for the ML model architectures and hyper-parameters. However, these AutoML pipelines only focus on improving the learning accuracy of benign samples while ignoring the ML model robustness under adversarial attacks. As ML systems are increasingly being used in a variety of mission-critical applications, improving the robustness of ML systems has become of utmost importance. In this paper, we propose the first robust AutoML framework, Robusta--based on reinforcement learning (RL)--to perform feature selection, aiming to select features that lead to both accurate and robust ML systems. We show that a variation of the 0-1 robust loss can be directly optimized via an RL-based combinatorial search in the feature selection scenario. In addition, we employ heuristics to accelerate the search procedure based on feature scoring metrics, which are mutual information scores, tree-based classifiers feature importance scores, F scores, and Integrated Gradient (IG) scores, as well as their combinations. We conduct extensive experiments and show that the proposed framework is able to improve the model robustness by up to 22% while maintaining competitive accuracy on benign samples compared with other feature selection methods.

Guanglin Niu, Yongfei Zhang, Bo Li et al.

Representation learning on a knowledge graph (KG) is to embed entities and relations of a KG into low-dimensional continuous vector spaces. Early KG embedding methods only pay attention to structured information encoded in triples, which would cause limited performance due to the structure sparseness of KGs. Some recent attempts consider paths information to expand the structure of KGs but lack explainability in the process of obtaining the path representations. In this paper, we propose a novel Rule and Path-based Joint Embedding (RPJE) scheme, which takes full advantage of the explainability and accuracy of logic rules, the generalization of KG embedding as well as the supplementary semantic structure of paths. Specifically, logic rules of different lengths (the number of relations in rule body) in the form of Horn clauses are first mined from the KG and elaborately encoded for representation learning. Then, the rules of length 2 are applied to compose paths accurately while the rules of length 1 are explicitly employed to create semantic associations among relations and constrain relation embeddings. Besides, the confidence level of each rule is also considered in optimization to guarantee the availability of applying the rule to representation learning. Extensive experimental results illustrate that RPJE outperforms other state-of-the-art baselines on KG completion task, which also demonstrate the superiority of utilizing logic rules as well as paths for improving the accuracy and explainability of representation learning.