Chen Ling

Hejie Cui, Jiaying Lu, Ran Xu et al.

This comprehensive review aims to provide an overview of the current state of Healthcare Knowledge Graphs (HKGs), including their construction, utilization models, and applications across various healthcare and biomedical research domains. We thoroughly analyzed existing literature on HKGs, covering their construction methodologies, utilization techniques, and applications in basic science research, pharmaceutical research and development, clinical decision support, and public health. The review encompasses both model-free and model-based utilization approaches and the integration of HKGs with large language models (LLMs). We searched Google Scholar for relevant papers on HKGs and classified them into the following topics: HKG construction, HKG utilization, and their downstream applications in various domains. We also discussed their special challenges and the promise for future work. The review highlights the potential of HKGs to significantly impact biomedical research and clinical practice by integrating vast amounts of biomedical knowledge from multiple domains. The synergy between HKGs and LLMs offers promising opportunities for constructing more comprehensive knowledge graphs and improving the accuracy of healthcare applications. HKGs have emerged as a powerful tool for structuring medical knowledge, with broad applications across biomedical research, clinical decision-making, and public health. This survey serves as a roadmap for future research and development in the field of HKGs, highlighting the potential of combining knowledge graphs with advanced machine learning models for healthcare transformation.

Chaoxi Niu, Hezhe Qiao, Changlu Chen et al.

Graph anomaly detection (GAD), which aims to identify nodes in a graph that significantly deviate from normal patterns, plays a crucial role in broad application domains. However, existing GAD methods are one-model-for-one-dataset approaches, i.e., training a separate model for each graph dataset. This largely limits their applicability in real-world scenarios. To overcome this limitation, we propose a novel zero-shot generalist GAD approach UNPrompt that trains a one-for-all detection model, requiring the training of one GAD model on a single graph dataset and then effectively generalizing to detect anomalies in other graph datasets without any retraining or fine-tuning. The key insight in UNPrompt is that i) the predictability of latent node attributes can serve as a generalized anomaly measure and ii) generalized normal and abnormal graph patterns can be learned via latent node attribute prediction in a properly normalized node attribute space. UNPrompt achieves a generalist mode for GAD through two main modules: one module aligns the dimensionality and semantics of node attributes across different graphs via coordinate-wise normalization, while another module learns generalized neighborhood prompts that support the use of latent node attribute predictability as an anomaly score across different datasets. Extensive experiments on real-world GAD datasets show that UNPrompt significantly outperforms diverse competing methods under the generalist GAD setting, and it also has strong superiority under the one-model-for-one-dataset setting. Code is available at https://github.com/mala-lab/UNPrompt.

Hezhe Qiao, Chaoxi Niu, Ling Chen et al.

Graph anomaly detection (GAD) aims to identify abnormal nodes that differ from the majority of the nodes in a graph, which has been attracting significant attention in recent years. Existing generalist graph models have achieved remarkable success in different graph tasks but struggle to generalize to the GAD task. This limitation arises from their difficulty in learning generalized knowledge for capturing the inherently infrequent, irregular and heterogeneous abnormality patterns in graphs from different domains. To address this challenge, we propose AnomalyGFM, a GAD-oriented graph foundation model that supports zero-shot inference and few-shot prompt tuning for GAD in diverse graph datasets. One key insight is that graph-agnostic representations for normal and abnormal classes are required to support effective zero/few-shot GAD across different graphs. Motivated by this, AnomalyGFM is pre-trained to align data-independent, learnable normal and abnormal class prototypes with node representation residuals (i.e., representation deviation of a node from its neighbors). The residual features essentially project the node information into a unified feature space where we can effectively measure the abnormality of nodes from different graphs in a consistent way. This provides a driving force for the learning of graph-agnostic, discriminative prototypes for the normal and abnormal classes, which can be used to enable zero-shot GAD on new graphs, including very large-scale graphs. If there are few-shot labeled normal nodes available in the new graphs, AnomalyGFM can further support prompt tuning to leverage these nodes for better adaptation. Comprehensive experiments on 11 widely-used GAD datasets with real anomalies, demonstrate that AnomalyGFM significantly outperforms state-of-the-art competing methods under both zero- and few-shot GAD settings.

Mingchen Li, Chen Ling, Rui Zhang et al.

Zero-shot link prediction (ZSLP) on knowledge graphs aims at automatically identifying relations between given entities. Existing methods primarily employ auxiliary information to predict tail entity given head entity and its relation, yet face challenges due to the occasional unavailability of such detailed information and the inherent simplicity of predicting tail entities based on semantic similarities. Even though Large Language Models (LLMs) offer a promising solution to predict unobserved relations between the head and tail entity in a zero-shot manner, their performance is still restricted due to the inability to leverage all the (exponentially many) paths' information between two entities, which are critical in collectively indicating their relation types. To address this, in this work, we introduce a Condensed Transition Graph Framework for Zero-Shot Link Prediction (CTLP), which encodes all the paths' information in linear time complexity to predict unseen relations between entities, attaining both efficiency and information preservation. Specifically, we design a condensed transition graph encoder with theoretical guarantees on its coverage, expressiveness, and efficiency. It is learned by a transition graph contrastive learning strategy. Subsequently, we design a soft instruction tuning to learn and map the all-path embedding to the input of LLMs. Experimental results show that our proposed CTLP method achieves state-of-the-art performance on three standard ZSLP datasets