Xiang Li

Yanjun Lyu, Zihao Wu, Lu Zhang et al.

Pre-trained large language models(LLMs) have attracted increasing attention in biomedical domains due to their success in natural language processing. However, the complex traits and heterogeneity of multi-sources genomics data pose significant challenges when adapting these models to the bioinformatics and biomedical field. To address these challenges, we present GP-GPT, the first specialized large language model for genetic-phenotype knowledge representation and genomics relation analysis. Our model is fine-tuned in two stages on a comprehensive corpus composed of over 3,000,000 terms in genomics, proteomics, and medical genetics, derived from multiple large-scale validated datasets and scientific publications. GP-GPT demonstrates proficiency in accurately retrieving medical genetics information and performing common genomics analysis tasks, such as genomics information retrieval and relationship determination. Comparative experiments across domain-specific tasks reveal that GP-GPT outperforms state-of-the-art LLMs, including Llama2, Llama3 and GPT-4. These results highlight GP-GPT's potential to enhance genetic disease relation research and facilitate accurate and efficient analysis in the fields of genomics and medical genetics. Our investigation demonstrated the subtle changes of bio-factor entities' representations in the GP-GPT, which suggested the opportunities for the application of LLMs to advancing gene-phenotype research.

Zhi-Qi Cheng, Xiang Li, Jun-Yan He et al. · cmu, uw

Emotional Text-to-Speech (E-TTS) synthesis has garnered significant attention in recent years due to its potential to revolutionize human-computer interaction. However, current E-TTS approaches often struggle to capture the intricacies of human emotions, primarily relying on oversimplified emotional labels or single-modality input. In this paper, we introduce the Unified Multimodal Prompt-Induced Emotional Text-to-Speech System (UMETTS), a novel framework that leverages emotional cues from multiple modalities to generate highly expressive and emotionally resonant speech. The core of UMETTS consists of two key components: the Emotion Prompt Alignment Module (EP-Align) and the Emotion Embedding-Induced TTS Module (EMI-TTS). (1) EP-Align employs contrastive learning to align emotional features across text, audio, and visual modalities, ensuring a coherent fusion of multimodal information. (2) Subsequently, EMI-TTS integrates the aligned emotional embeddings with state-of-the-art TTS models to synthesize speech that accurately reflects the intended emotions. Extensive evaluations show that UMETTS achieves significant improvements in emotion accuracy and speech naturalness, outperforming traditional E-TTS methods on both objective and subjective metrics.

Junyu Liu, Xiang Li, Jin Wang et al.

Recent breakthroughs made by deep learning rely heavily on large number of annotated samples. To overcome this shortcoming, active learning is a possible solution. Beside the previous active learning algorithms that only adopted information after training, we propose a new class of method based on the information during training, named sequential-based method. An specific criterion of active learning called prediction stability is proposed to prove the feasibility of sequential-based methods. Experiments are made on CIFAR-10 and CIFAR-100, and the results indicates that prediction stability is effective and works well on fewer-labeled datasets. Prediction stability reaches the accuracy of traditional acquisition functions like entropy on CIFAR-10, and notably outperforms them on CIFAR-100.