Haiyu Wang

Leshu Li, An Lu, Haiyu Wang et al.

Lipid nanoparticles (LNPs) are among the most clinically mature platforms for nucleic acid delivery, yet designing lipids that are both effective and biologically safe remains a major bottleneck. In practical screening, toxicity is a decision-level constraint: if a lipid is toxic, its efficiency prediction is clinically irrelevant. We propose LipoAgent, a safety-aware multi-agent LLM framework for lipid discovery. LipoAgent combines domain-specific finetuning with a conditional prediction objective that enforces toxicity as a prerequisite for efficiency prediction, and further improves reliability via multi-agent verification with lightweight human oversight when disagreement persists. Across multiple foundation models, LipoAgent achieves an average 32% relative improvement in mRNA transfection efficiency prediction compared with other reported models for lipid design. Wet-lab validation confirms that virtual screening rankings reliably translate to biological transfection outcomes. The code is publicly available at https://github.com/SAI-Lab-NYU/LipoAgent.git.

Haiyu Wang, Yutong Wang, Leshu Li et al.

Vision-language models (VLMs) deliver strong multimodal reasoning capabilities, but their large computational cost and high parameter counts make deployment challenging on resource-constrained devices. Low-rank decomposition has emerged as a promising compression technique, yet existing methods often optimize local matrix reconstruction error, rely on uniform or heuristic rank allocation, and focus mainly on attention projections while leaving feed-forward networks underexplored. In this paper, we propose~\textit{LASER} (\textbf{L}oss-\textbf{A}ware \textbf{S}ingular-value d\textbf{E}composition and \textbf{R}ank allocation), a low-rank compression framework for efficient low-precision VLM inference. LASER derives a curvature-weighted SVD objective from a second-order approximation of the model loss and uses Kronecker-factored Fisher information to guide decomposition toward downstream performance rather than reconstruction alone. We further introduce a loss-aware cross-layer rank allocation strategy based on calibration gradients, enabling more effective parameter budgeting across layers. Finally, we extend low-rank compression to FFN layers through a hybrid scheme that combines SVD with quantization. The evaluation results show that LASER achieves more than $2.3\times$ decoding speedup over previous work while preserving strong accuracy under low-precision inference.

Haiyu Wang, Yutong Wang, Jack Jiang et al.

Singular Value Decomposition (SVD) has become an important technique for reducing the computational burden of Vision Language Models (VLMs), which play a central role in tasks such as image captioning and visual question answering. Although multiple prior works have proposed efficient SVD variants to enable low-rank operations, we find that in practice it remains difficult to achieve substantial latency reduction during model execution. To address this limitation, we introduce a new computational pattern and apply SVD at a finer granularity, enabling real and measurable improvements in execution latency. Furthermore, recognizing that weight elements differ in their relative importance, we adaptively allocate relative importance to each element during SVD process to better preserve accuracy, then extend this framework with quantization applied to both weights and activations, resulting in a highly efficient VLM. Collectively, we introduce~\textit{Weighted SVD} (WSVD), which outperforms other approaches by achieving over $1.8\times$ decoding speedup while preserving accuracy. We open source our code at: \href{https://github.com/SAI-Lab-NYU/WSVD}{\texttt{https://github.com/SAI-Lab-NYU/WSVD}

Yutong Wang, Haiyu Wang, Sai Qian Zhang

Vision-Language Models (VLMs) are integral to tasks such as image captioning and visual question answering, but their high computational cost, driven by large memory footprints and processing time, limits their scalability and real-time applicability. In this work, we propose leveraging Singular-Value Decomposition (SVD) over the joint query (Q), key (K), and value (V) weight matrices to reduce KV cache size and computational overhead. We in addition introduce an efficient rank allocation strategy that dynamically adjusts the SVD rank based on its impact on VLM accuracy, achieving a significant reduction in both memory usage and computational cost. Finally, we extend this approach by applying quantization to both VLM weights and activations, resulting in a highly efficient VLM. Our method outperforms previous approaches that rely solely on quantization or SVD by achieving more than $10\%$ accuracy improvement while consuming less hardware cost, making it better for real-time deployment on resource-constrained devices. We open source our code at \href{https://github.com/SAI-Lab-NYU/QSVD}{\texttt{https://github.com/SAI-Lab-NYU/QSVD}}.

Shuo Xin, Haiyu Wang, Sai Qian Zhang

Virtual reality (VR) significantly transforms immersive digital interfaces, greatly enhancing education, professional practices, and entertainment by increasing user engagement and opening up new possibilities in various industries. Among its numerous applications, image rendering is crucial. Nevertheless, rendering methodologies like 3D Gaussian Splatting impose high computational demands, driven predominantly by user expectations for superior visual quality. This results in notable processing delays for real-time image rendering, which greatly affects the user experience. Additionally, VR devices such as head-mounted displays (HMDs) are intricately linked to human visual behavior, leveraging knowledge from perception and cognition to improve user experience. These insights have spurred the development of foveated rendering, a technique that dynamically adjusts rendering resolution based on the user's gaze direction. The resultant solution, known as gaze-tracked foveated rendering, significantly reduces the computational burden of the rendering process. Although gaze-tracked foveated rendering can reduce rendering costs, the computational overhead of the gaze tracking process itself can sometimes outweigh the rendering savings, leading to increased processing latency. To address this issue, we propose an efficient rendering framework called~\textit{A3FR}, designed to minimize the latency of gaze-tracked foveated rendering via the parallelization of gaze tracking and foveated rendering processes. For the rendering algorithm, we utilize 3D Gaussian Splatting, a state-of-the-art neural rendering technique. Evaluation results demonstrate that A3FR can reduce end-to-end rendering latency by up to $2\times$ while maintaining visual quality.