Liqin Wang

Feng Chen, Liqin Wang, Julie Hong et al.

Objectives: Leveraging artificial intelligence (AI) in conjunction with electronic health records (EHRs) holds transformative potential to improve healthcare. Yet, addressing bias in AI, which risks worsening healthcare disparities, cannot be overlooked. This study reviews methods to detect and mitigate diverse forms of bias in AI models developed using EHR data. Methods: We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, analyzing articles from PubMed, Web of Science, and IEEE published between January 1, 2010, and Dec 17, 2023. The review identified key biases, outlined strategies for detecting and mitigating bias throughout the AI model development process, and analyzed metrics for bias assessment. Results: Of the 450 articles retrieved, 20 met our criteria, revealing six major bias types: algorithmic, confounding, implicit, measurement, selection, and temporal. The AI models were primarily developed for predictive tasks in healthcare settings. Four studies concentrated on the detection of implicit and algorithmic biases employing fairness metrics like statistical parity, equal opportunity, and predictive equity. Sixty proposed various strategies for mitigating biases, especially targeting implicit and selection biases. These strategies, evaluated through both performance (e.g., accuracy, AUROC) and fairness metrics, predominantly involved data collection and preprocessing techniques like resampling, reweighting, and transformation. Discussion: This review highlights the varied and evolving nature of strategies to address bias in EHR-based AI models, emphasizing the urgent needs for the establishment of standardized, generalizable, and interpretable methodologies to foster the creation of ethical AI systems that promote fairness and equity in healthcare.

Jiazi Tian, Liqin Wang, Pedram Fard et al.

Early identification of cognitive concerns is critical but often hindered by subtle symptom presentation. This study developed and validated a fully automated, multi-agent AI workflow using LLaMA 3 8B to identify cognitive concerns in 3,338 clinical notes from Mass General Brigham. The agentic workflow, leveraging task-specific agents that dynamically collaborate to extract meaningful insights from clinical notes, was compared to an expert-driven benchmark. Both workflows achieved high classification performance, with F1-scores of 0.90 and 0.91, respectively. The agentic workflow demonstrated improved specificity (1.00) and achieved prompt refinement in fewer iterations. Although both workflows showed reduced performance on validation data, the agentic workflow maintained perfect specificity. These findings highlight the potential of fully automated multi-agent AI workflows to achieve expert-level accuracy with greater efficiency, offering a scalable and cost-effective solution for detecting cognitive concerns in clinical settings.

Lingxiao Chen, Liqin Wang, Wei Lu

The versatility of diffusion models in generating customized images has led to unauthorized usage of personal artwork, which poses a significant threat to the intellectual property of artists. Existing approaches relying on embedding additional information, such as perturbations, watermarks, and backdoors, suffer from limited defensive capabilities and fail to protect artwork published online. In this paper, we propose StyleSentinel, an approach for copyright protection of artwork by verifying an inherent stylistic fingerprint in the artist's artwork. Specifically, we employ a semantic self-reconstruction process to enhance stylistic expressiveness within the artwork, which establishes a dense and style-consistent manifold foundation for feature learning. Subsequently, we adaptively fuse multi-layer image features to encode abstract artistic style into a compact stylistic fingerprint. Finally, we model the target artist's style as a minimal enclosing hypersphere boundary in the feature space, transforming complex copyright verification into a robust one-class learning task. Extensive experiments demonstrate that compared with the state-of-the-art, StyleSentinel achieves superior performance on the one-sample verification task. We also demonstrate the effectiveness through online platforms.

Yifei Wang, Zhengyang Zhou, Liqin Wang et al.

When using machine learning to aid decision-making, it is critical to ensure that an algorithmic decision is fair and does not discriminate against specific individuals/groups, particularly those from underprivileged populations. Existing group fairness methods aim to ensure equal outcomes (such as loan approval rates) across groups delineated by protected variables like race or gender. However, in cases where systematic differences between groups play a significant role in outcomes, these methods may overlook the influence of non-protected variables that can systematically vary across groups. These confounding factors can affect fairness evaluations, making it challenging to assess whether disparities are due to discrimination or inherent differences. Therefore, we recommend a more refined and comprehensive fairness index that accounts for both the systematic differences within groups and the multifaceted, intertwined confounding effects. The proposed index evaluates fairness on counterparts (pairs of individuals who are similar with respect to the task of interest but from different groups), whose group identities cannot be distinguished algorithmically by exploring confounding factors. To identify counterparts, we developed a two-step matching method inspired by propensity score and metric learning. In addition, we introduced a counterpart-based statistical fairness index, called Counterpart Fairness (CFair), to assess the fairness of machine learning models. Empirical results on the MIMIC and COMPAS datasets indicate that standard group-based fairness metrics may not adequately inform about the degree of unfairness present in predictions, as revealed through CFair.