Zhixiang Wang

Wang Cai, Hsiu-Yuan Huang, Zhixiang Wang et al.

In-Context derived Vector (ICV) methods extract task-relevant representations from large language models (LLMs) and reinject them during inference, achieving comparable performance to few-shot In-Context Learning (ICL) without repeated demonstration processing. However, existing ICV methods remain sensitive to ICL-specific factors, often use coarse or semantically fragmented representations as the source of the vector, and rely on heuristic-based injection positions, limiting their applicability. To address these issues, we propose Dynamic Vector (DyVec), which incorporates an Exhaustive Query Rotation (EQR) strategy to extract robust semantically aggregated latent representations by mitigating variance introduced by ICL. It then applies Dynamic Latent Segmentation and Injection to adaptively partition representations based on task complexity and leverages REINFORCE-based optimization to learn optimal injection positions for each segment. Experiments results show that DyVec outperforms few-shot ICL, LoRA, and prior ICV baselines. Further analysis highlights the effectiveness of dynamically segmenting and injecting semantically aggregated latent representations. DyVec provides a lightweight and data-efficient solution for inference-time task adaptation.

Junzhuo Liu, Markus Eckstein, Zhixiang Wang et al.

Spatial transcriptomics is a technology that captures gene expression levels at different spatial locations, widely used in tumor microenvironment analysis and molecular profiling of histopathology, providing valuable insights into resolving gene expression and clinical diagnosis of cancer. Due to the high cost of data acquisition, large-scale spatial transcriptomics data remain challenging to obtain. In this study, we develop a contrastive learning-based deep learning method to predict spatially resolved gene expression from whole-slide images. Evaluation across six different disease datasets demonstrates that, compared to existing studies, our method improves Pearson Correlation Coefficient (PCC) in the prediction of highly expressed genes, highly variable genes, and marker genes by 6.27%, 6.11%, and 11.26% respectively. Further analysis indicates that our method preserves gene-gene correlations and applies to datasets with limited samples. Additionally, our method exhibits potential in cancer tissue localization based on biomarker expression.