Lin Tian

Basar Demir, Lin Tian, Thomas Hastings Greer et al. · harvard

Modern medical image registration approaches predict deformations using deep networks. These approaches achieve state-of-the-art (SOTA) registration accuracy and are generally fast. However, deep learning (DL) approaches are, in contrast to conventional non-deep-learning-based approaches, anatomy-specific. Recently, a universal deep registration approach, uniGradICON, has been proposed. However, uniGradICON focuses on monomodal image registration. In this work, we therefore develop multiGradICON as a first step towards universal *multimodal* medical image registration. Specifically, we show that 1) we can train a DL registration model that is suitable for monomodal *and* multimodal registration; 2) loss function randomization can increase multimodal registration accuracy; and 3) training a model with multimodal data helps multimodal generalization. Our code and the multiGradICON model are available at https://github.com/uncbiag/uniGradICON.

Lin Tian, Hastings Greer, François-Xavier Vialard et al. · harvard

We present an approach to learning regular spatial transformations between image pairs in the context of medical image registration. Contrary to optimization-based registration techniques and many modern learning-based methods, we do not directly penalize transformation irregularities but instead promote transformation regularity via an inverse consistency penalty. We use a neural network to predict a map between a source and a target image as well as the map when swapping the source and target images. Different from existing approaches, we compose these two resulting maps and regularize deviations of the $\bf{Jacobian}$ of this composition from the identity matrix. This regularizer -- $\texttt{GradICON}$ -- results in much better convergence when training registration models compared to promoting inverse consistency of the composition of maps directly while retaining the desirable implicit regularization effects of the latter. We achieve state-of-the-art registration performance on a variety of real-world medical image datasets using a single set of hyperparameters and a single non-dataset-specific training protocol.

Lin Tian, Xiuzhen Zhang, Jey Han Lau

State-sponsored trolls are the main actors of influence campaigns on social media and automatic troll detection is important to combat misinformation at scale. Existing troll detection models are developed based on training data for known campaigns (e.g.\ the influence campaign by Russia's Internet Research Agency on the 2016 US Election), and they fall short when dealing with {\em novel} campaigns with new targets. We propose MetaTroll, a text-based troll detection model based on the meta-learning framework that enables high portability and parameter-efficient adaptation to new campaigns using only a handful of labelled samples for few-shot transfer. We introduce \textit{campaign-specific} transformer adapters to MetaTroll to ``memorise'' campaign-specific knowledge so as to tackle catastrophic forgetting, where a model ``forgets'' how to detect trolls from older campaigns due to continual adaptation. Our experiments demonstrate that MetaTroll substantially outperforms baselines and state-of-the-art few-shot text classification models. Lastly, we explore simple approaches to extend MetaTroll to multilingual and multimodal detection. Source code for MetaTroll is available at: https://github.com/ltian678/metatroll-code.git.

Meng Wang, Tian Lin, Lianyu Wang et al.

Failure to recognize samples from the classes unseen during training is a major limitation of artificial intelligence in the real-world implementation for recognition and classification of retinal anomalies. We established an uncertainty-inspired open-set (UIOS) model, which was trained with fundus images of 9 retinal conditions. Besides assessing the probability of each category, UIOS also calculated an uncertainty score to express its confidence. Our UIOS model with thresholding strategy achieved an F1 score of 99.55%, 97.01% and 91.91% for the internal testing set, external target categories (TC)-JSIEC dataset and TC-unseen testing set, respectively, compared to the F1 score of 92.20%, 80.69% and 64.74% by the standard AI model. Furthermore, UIOS correctly predicted high uncertainty scores, which would prompt the need for a manual check in the datasets of non-target categories retinal diseases, low-quality fundus images, and non-fundus images. UIOS provides a robust method for real-world screening of retinal anomalies.

Lin Tian, Yueh Z. Lee, Raúl San José Estépar et al. · harvard

We propose LiftReg, a 2D/3D deformable registration approach. LiftReg is a deep registration framework which is trained using sets of digitally reconstructed radiographs (DRR) and computed tomography (CT) image pairs. By using simulated training data, LiftReg can use a high-quality CT-CT image similarity measure, which helps the network to learn a high-quality deformation space. To further improve registration quality and to address the inherent depth ambiguities of very limited angle acquisitions, we propose to use features extracted from the backprojected 2D images and a statistical deformation model. We test our approach on the DirLab lung registration dataset and show that it outperforms an existing learning-based pairwise registration approach.

Ke Zou, Tian Lin, Xuedong Yuan et al.

Multimodality eye disease screening is crucial in ophthalmology as it integrates information from diverse sources to complement their respective performances. However, the existing methods are weak in assessing the reliability of each unimodality, and directly fusing an unreliable modality may cause screening errors. To address this issue, we introduce a novel multimodality evidential fusion pipeline for eye disease screening, EyeMoSt, which provides a measure of confidence for unimodality and elegantly integrates the multimodality information from a multi-distribution fusion perspective. Specifically, our model estimates both local uncertainty for unimodality and global uncertainty for the fusion modality to produce reliable classification results. More importantly, the proposed mixture of Student's $t$ distributions adaptively integrates different modalities to endow the model with heavy-tailed properties, increasing robustness and reliability. Our experimental findings on both public and in-house datasets show that our model is more reliable than current methods. Additionally, EyeMost has the potential ability to serve as a data quality discriminator, enabling reliable decision-making for multimodality eye disease screening.

Lin Tian, Hastings Greer, Roland Kwitt et al. · harvard

Conventional medical image registration approaches directly optimize over the parameters of a transformation model. These approaches have been highly successful and are used generically for registrations of different anatomical regions. Recent deep registration networks are incredibly fast and accurate but are only trained for specific tasks. Hence, they are no longer generic registration approaches. We therefore propose uniGradICON, a first step toward a foundation model for registration providing 1) great performance \emph{across} multiple datasets which is not feasible for current learning-based registration methods, 2) zero-shot capabilities for new registration tasks suitable for different acquisitions, anatomical regions, and modalities compared to the training dataset, and 3) a strong initialization for finetuning on out-of-distribution registration tasks. UniGradICON unifies the speed and accuracy benefits of learning-based registration algorithms with the generic applicability of conventional non-deep-learning approaches. We extensively trained and evaluated uniGradICON on twelve different public datasets. Our code and the uniGradICON model are available at https://github.com/uncbiag/uniGradICON.

Lin Tian, Emily Booth, Francesco Bailo et al.

In today's digital age, conspiracies and information campaigns can emerge rapidly and erode social and democratic cohesion. While recent deep learning approaches have made progress in modeling engagement through language and propagation models, they struggle with irregularly sampled data and early trajectory assessment. We present IC-Mamba, a novel state space model that forecasts social media engagement by modeling interval-censored data with integrated temporal embeddings. Our model excels at predicting engagement patterns within the crucial first 15-30 minutes of posting (RMSE 0.118-0.143), enabling rapid assessment of content reach. By incorporating interval-censored modeling into the state space framework, IC-Mamba captures fine-grained temporal dynamics of engagement growth, achieving a 4.72% improvement over state-of-the-art across multiple engagement metrics (likes, shares, comments, and emojis). Our experiments demonstrate IC-Mamba's effectiveness in forecasting both post-level dynamics and broader narrative patterns (F1 0.508-0.751 for narrative-level predictions). The model maintains strong predictive performance across extended time horizons, successfully forecasting opinion-level engagement up to 28 days ahead using observation windows of 3-10 days. These capabilities enable earlier identification of potentially problematic content, providing crucial lead time for designing and implementing countermeasures. Code is available at: https://github.com/ltian678/ic-mamba. An interactive dashboard demonstrating our results is available at: https://ic-mamba.behavioral-ds.science.

Lin Tian, Sean I. Young, Jonathan Williams Ramirez et al. · harvard

Correlation of neuropathology with MRI has the potential to transfer microscopic signatures of pathology to invivo scans. Recently, a classical registration method has been proposed, to build these correlations from 3D reconstructed stacks of dissection photographs, which are routinely taken at brain banks. These photographs bypass the need for exvivo MRI, which is not widely accessible. However, this method requires a full stack of brain slabs and a reference mask (e.g., acquired with a surface scanner), which severely limits the applicability of the technique. Here we propose RefFree, a dissection photograph reconstruction method without external reference. RefFree is a learning approach that estimates the 3D coordinates in the atlas space for every pixel in every photograph; simple least-squares fitting can then be used to compute the 3D reconstruction. As a by-product, RefFree also produces an atlas-based segmentation of the reconstructed stack. RefFree is trained on synthetic photographs generated from digitally sliced 3D MRI data, with randomized appearance for enhanced generalization ability. Experiments on simulated and real data show that RefFree achieves performance comparable to the baseline method without an explicit reference while also enabling reconstruction of partial stacks. Our code is available at https://github.com/lintian-a/reffree.

Lin Tian, Xiuzhen Zhang, Jey Han Lau

We apply causal mediation analysis to explain the decision-making process of neural models for rumour detection on Twitter. Interventions at the input and network level reveal the causal impacts of tweets and words in the model output. We find that our approach CMA-R -- Causal Mediation Analysis for Rumour detection -- identifies salient tweets that explain model predictions and show strong agreement with human judgements for critical tweets determining the truthfulness of stories. CMA-R can further highlight causally impactful words in the salient tweets, providing another layer of interpretability and transparency into these blackbox rumour detection systems. Code is available at: https://github.com/ltian678/cma-r.

Lin Tian, Marian-Andrei Rizoiu

Understanding true influence in social media requires distinguishing correlation from causation--particularly when analyzing misinformation spread. While existing approaches focus on exposure metrics and network structures, they often fail to capture the causal mechanisms by which external temporal signals trigger engagement. We introduce a novel joint treatment-outcome framework that leverages existing sequential models to simultaneously adapt to both policy timing and engagement effects. Our approach adapts causal inference techniques from healthcare to estimate Average Treatment Effects (ATE) within the sequential nature of social media interactions, tackling challenges from external confounding signals. Through our experiments on real-world misinformation and disinformation datasets, we show that our models outperform existing benchmarks by 15--22% in predicting engagement across diverse counterfactual scenarios, including exposure adjustment, timing shifts, and varied intervention durations. Case studies on 492 social media users show our causal effect measure aligns strongly with the gold standard in influence estimation, the expert-based empirical influence.

Lin Tian, Xiaoling Hu, Juan Eugenio Iglesias · harvard

Accurate image registration is essential for downstream applications, yet current deep registration networks provide limited indications of whether and when their predictions are reliable. Existing uncertainty estimation strategies, such as Bayesian methods, ensembles, or MC dropout, require architectural changes or retraining, limiting their applicability to pretrained registration networks. Instead, we propose a test-time uncertainty estimation framework that is compatible with any pretrained networks. Our framework is grounded in the transformation equivariance property of registration, which states that the true mapping between two images should remain consistent under spatial perturbations of the input. By analyzing the variance of network predictions under such perturbations, we derive a theoretical decomposition of perturbation-based uncertainty in registration. This decomposition separates into two terms: (i) an intrinsic spread, reflecting epistemic noise, and (ii) a bias jitter, capturing how systematic error drifts under perturbations. Across four anatomical structures (brain, cardiac, abdominal, and lung) and multiple registration models (uniGradICON, SynthMorph), the uncertainty maps correlate consistently with registration errors and highlight regions requiring caution. Our framework turns any pretrained registration network into a risk-aware tool at test time, placing medical image registration one step closer to safe deployment in clinical and large-scale research settings.

Lin Tian, Xiuzhen Zhang, Jey Han Lau

Most rumour detection models for social media are designed for one specific language (mostly English). There are over 40 languages on Twitter and most languages lack annotated resources to build rumour detection models. In this paper we propose a zero-shot cross-lingual transfer learning framework that can adapt a rumour detection model trained for a source language to another target language. Our framework utilises pretrained multilingual language models (e.g.\ multilingual BERT) and a self-training loop to iteratively bootstrap the creation of ''silver labels'' in the target language to adapt the model from the source language to the target language. We evaluate our methodology on English and Chinese rumour datasets and demonstrate that our model substantially outperforms competitive benchmarks in both source and target language rumour detection.

Yuriy Brun, Tian Lin, Jessie Elise Somerville et al.

Blindspots in APIs can cause software engineers to introduce vulnerabilities, but such blindspots are, unfortunately, common. We study the effect APIs with blindspots have on developers in two languages by replicating an 109-developer, 24-Java-API controlled experiment. Our replication applies to Python and involves 129 new developers and 22 new APIs. We find that using APIs with blindspots statistically significantly reduces the developers' ability to correctly reason about the APIs in both languages, but that the effect is more pronounced for Python. Interestingly, for Java, the effect increased with complexity of the code relying on the API, whereas for Python, the opposite was true. Whether the developers considered API uses to be more difficult, less clear, and less familiar did not have an effect on their ability to correctly reason about them. Developers with better long-term memory recall were more likely to correctly reason about APIs with blindspots, but short-term memory, processing speed, episodic memory, and memory span had no effect. Surprisingly, professional experience and expertice did not improve the developers' ability to reason about APIs with blindspots across both languages, with long-term professionals with many years of experience making mistakes as often as relative novices. Finally, personality traits did not significantly affect the Python developers' ability to reason about APIs with blindspots, but less extraverted and more open developers were better at reasoning about Java APIs with blindspots. Overall, our findings suggest that blindspots in APIs are a serious problem across languages, and that experience and education alone do not overcome that problem, suggesting that tools are needed to help developers recognize blindspots in APIs as they write code that uses those APIs.